Anterior Repair With or Without Collagen Matrix Reinforcement

Guerette, Nathan; Peterson, Thais V.; Aguirre, Oscar; VanDrie, D.; Biller, Daniel H; Davila, G. Willy

doi:10.1097/aog.0b013e3181a81b41

Cited by 48 publications

(44 citation statements)

References 16 publications

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“…Twelve studied non-absorbable synthetic (NAS) polypropylene implants [6, 8-12, 14, 16, 19-22] and six absorbable biomesh (AB) [5,7,13,15,17,18]. Anatomic results are summed up in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Improvement of symptoms and quality of life were the main objectives of two studies: Nieminen in 2008 (polypropylene NAS mesh versus colporrhaphy) and Guerette in 2009 (bovine pericardium graft versus colporrhaphy) [13,21]. They were secondary objectives in the other 15 studies.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen randomized trials matching our inclusion criteria were published: one in 2006 [5], two in 2007 [6,7], four in 2008 [8][9][10][11], four in 2009 [12][13][14][15] and five in 2010 [16][17][18][19][20]. We added two publications of Nieminen, reporting long-term results of the randomized trial initially written by Hiltunen in 2007 [6,21,22].…”

Section: Resultsmentioning

confidence: 99%

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Use of vaginal mesh for pelvic organ prolapse repair: a literature review

et al. 2011

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The use of mesh for pelvic organ prolapse repair through the vaginal route has increased during this last decade. The objective is to improve anatomical results (sacropexy with mesh seeming better than traditional surgery) and keep still the advantage of vaginal route. Numbers of cohort series and randomized control trials have been recently published. These works increase our knowledge of advantages and risks of mesh. It has been shown that the use of mesh to treat cystocoele through vaginal route improves anatomical results when compared to traditional surgery. The rate of complications, especially de novo dyspareunia, remains equivalent between the two techniques.

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“…Twelve studied non-absorbable synthetic (NAS) polypropylene implants [6, 8-12, 14, 16, 19-22] and six absorbable biomesh (AB) [5,7,13,15,17,18]. Anatomic results are summed up in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Use of vaginal mesh for pelvic organ prolapse repair: a literature review

et al. 2011

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“…[21] The review also emphasized that, although some data were limited, there were no differences in the subjective outcomes, QoL data, de novo dyspareunia, SUI, and reoperation rates for prolapse or incontinence between the augmented and standard procedures. Guerette et al [30] determined that the anatomic success rate at two years of follow-up was similar in women undergoing bovine pericardium interposition and those undergoing anterior colporrhaphy alone. At 12 months of follow-up, Carey et al [31] observed an anatomic success rate of 81% in women undergoing polypropylene mesh augmentation vs. 65.6% in the no-mesh group, with a high level of postoperative satisfaction and QoL improvement observed in both groups.…”

Section: Interposition Grafts For Pop Repairmentioning

confidence: 99%

Optimal repair of pelvic organ prolapse: the debate continues

Gomelsky¹,

Dmochowski²

2012

Turkish Journal of Urology

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As the need for durable pelvic organ prolapse (POP) repairs continues to increase, greater scrutiny has been placed on finding the optimal repair. Evidence-based literature indicates that the durability of standard (plication-type) repairs in the anterior compartment is suboptimal and that graft augmentation, especially with non-absorbable, synthetic mesh, may be superior. However, while appealing, the transvaginal mesh used for POP repair may be associated with adverse sequelae, such as erosion, extrusion, and infection. Additionally, there is concern regarding the potential long-term outcomes, such as dyspareunia, chronic pelvic pain, and vaginal distortion, which may occur even in the absence of frank extrusion. Recent warnings by the U.S. FDA among other groups regarding adverse events after transvaginal mesh implantation have fueled the debate even further. Our aim is to summarize the available literature regarding the available surgical options for the repair of POP.Key words: Female; pelvic organ prolapse; postoperative complications; treatment outcome. ÖZETPelvik organ prolapsının (POP) kalıcı onarımı için ihtiyaç artmaya devam ettiğinden, optimal onarım üze-rine daha detaylı inceleme yapılmaktadır. Kanıta dayalı literatür ön kompartmandaki standart (pilikasyon tipi) onarımların kalıcılığının optimalin altında olduğunu ve, özellikle absorbe olmayan, sentetik meş bir graft ile güçlendirmenin, daha üstün olabileceğini göstermektedir. Bununla birlikte çekici olmasına karşın, POP onarımı için kullanılan transvajinal meş, erozyon, ekstrüzyon ve enfeksiyon gibi advers sekellerle iliş-kili olabilir. Ek olarak, cinsel ilişki sırasında ağrı, kronik pelvis ağrısı ve belirgin bir ekstrüzyon olmasa bile görülebilen vajina distorsiyonu gibi potansiyel uzun dönem sonuçlar hakkında kaygılar vardır. Transvajinal meş implantasyonundan sonra advers olaylarla ilgili diğer gruplar arasında ABD FDA'in yakın zamandaki uyarıları tartışmayı daha da alevlendirmiştir. Amacımız POP'un onarımı için var olan cerrahi seçeneklerle ilişkili mevcut literatürü özetlemektir.Anahtar sözcükler: Kadın; pelvik organ prolapsı; postoperatif komplikasyonlar; tedavi sonucu. FEMALE UROLOGY

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“…7,8 Recent studies have examined the use of acellular bovine pericardium (ABP) grafts as a scaffold in pelvic floor reconstruction. 9 Human adipose-derived stem cells (hASCs) are a suitable option for reseeding, because it is convenient to harvest them in large quantities using minimally invasive techniques, and additionally, these MSCs maybe reduce the immune response. 10 Recent data also suggest that the multipotency and proliferative efficiency of hASCs are as effective as that of bone mesenchymal stem cells, and they improve collagen production and differentiation of smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice

Dai

et al. 2015

Exp Biol Med (Maywood)

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Tissue-engineered biologic products may be a viable option in the reconstruction of pelvic organ prolapse (POP). This study was based on the hypothesis that human adipose-derived stem cells (hASCs) are viable in acellular bovine pericardium (ABP), when reseeded by two different techniques, and thus, aid in the reconstruction. To investigate the reseeding of hASCs on ABP grafts by using non-invasive bioluminescence imaging (BLI), and to identify the effective hASCs-scaffold combinations that enabled regeneration. Thirty female athymic nude mice were randomly divided into three groups: In the VIVO group, ABPs were implanted in the subcutaneous pockets and enhanced green fluorescent protein luciferase (eGFPÁLuc)-hASCs (1 Â 10 6 cells/50 mL) were injected on the ABP at the same time. In the VITRO group, the mice were implanted with grafts that ABP were co-cultured with eGFPÁLuc-hASCs in vitro. The BLANK group mice were implanted with ABP only. The eGFPÁLuc-hASCs reseeded on ABP were analyzed by BLI, histology, and immunohistochemistry. The eGFPÁLuc-hASCs reseeded on ABP could be visualized at 12 weeks in vivo. Histology revealed that the VIVO group displayed the highest cell ingrowths, small vessels, and percent of collagen content per unit area. Desmin and a-smooth muscle actin were positive at the same site in the VIVO group cells. However, few smooth muscles were observed in the VITRO and BLANK groups. These results suggest that hASCs reseeded on ABP in vivo during surgery may further enhance the properties of ABP and may promote regeneration at the recipient site, resulting in a promising treatment option for POP.

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Anterior Repair With or Without Collagen Matrix Reinforcement

Abstract: I.

Cited by 48 publications

References 16 publications

Use of vaginal mesh for pelvic organ prolapse repair: a literature review

Use of vaginal mesh for pelvic organ prolapse repair: a literature review

Optimal repair of pelvic organ prolapse: the debate continues

In vivo effects of human adipose-derived stem cells reseeding on acellular bovine pericardium in nude mice

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