Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

Brouwer, Niels J.; Marinković, Marina; Bleeker, J.C.; Luyten, Gregorius P M; Jager, Martine J.

doi:10.1016/j.ajo.2020.09.009

Cited by 25 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although benign iris lesions may show more organized vascular patterns compared with their malignant counterparts, there has been no consensus regarding the interpretation of angiographic findings, and therefore, the diagnostic value is uncertain. 9 The five cases in our series each presented with a different combination of the ABCDEF risk factors. Some were highly suggestive of melanoma, and others, less so.…”

Section: Discussionmentioning

confidence: 89%

Case Series: Different Presentations of Iris Melanoma—Potential Masquerade of Benign and Malignant

et al. 2021

View full text Add to dashboard Cite

Iris melanoma and iris nevi can be challenging to distinguish clinically. This case series provides unique insight into the rare condition and variable clinical presentations of iris melanoma.PURPOSE: This study aimed to highlight the varying clinical presentations of iris melanoma and to demonstrate the overlapping features of melanoma and nevi.CASE REPORTS: This case series includes five patients of varying age and sex who presented to clinic with pigmented iris lesions. These five patients have differing timeline to presentation and very different clinical presentations of their lesions. Clinical evaluation was based around the established "ABDCEF" guide for the assessment of malignant risk in iris lesions. The presentation of each lesion is discussed in relation to this guide and the experienced clinician's clinical suspicion of malignancy. When comparing the clinical suspicion with histological analysis, after biopsy, the result may be unexpected. Notably, initially benign nevi may transform into melanoma over time. These five cases were managed on an individual basis because the management and prognosis of iris melanomas vary significantly. Importantly, iris melanotic lesions have variable metastatic risk based on cytology and genetic predisposition. Informed consent was obtained from all the patients, institutional approval was obtained, and no identifiable health information is included in this case series.CONCLUSIONS: When presented with a pigmented iris lesion, clinicians must be vigilant with regular monitoring and have a low threshold for biopsy in pigmented lesions of high clinical suspicion.

show abstract

Section: Discussionmentioning

confidence: 89%

Case Series: Different Presentations of Iris Melanoma—Potential Masquerade of Benign and Malignant

et al. 2021

View full text Add to dashboard Cite

show abstract

“…(36) Although vascular patterns of the melanocytic lesions were distinct from healthy tissue, no differentiating OCTA features were found between nevi and melanoma of either the conjunctiva or iris. (37) Study showed that OCTA can be used in anterior segment ocular oncology, but better software and enhanced imaging techniques are needed before conclusions about its clinical utility can be drawn. Imaging techniques that are not dependent on light (such as ultrasound biomicroscopy, using sound waves) may be more suitable to depict tumor size.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management

Rehmani

Charan

Rani

2022

Int J Sci Healthcare Res

View full text Add to dashboard Cite

Introduction- Iris melanomas mainly grow in the anterior chamber or along the iris surface, and by local extension; they commonly invade the anterior chamber angle and anterior ciliary body. Iris melanomas account for 2–3% of all uveal melanomas, with the diffuse variety accounting for about 10% of all iris melanomas. Methodology-A systematic review is a technical tool that basically describes a more or less systematic way of collecting and synthesizing past research by integrating findings and perspectives from a variety of empirical findings. In this study, authors conducted a systematic assessment of 51 research articles on the subject of "Iris Melanoma" in order to examine and compare the various approaches and outcomes. This comprehensive review summarizes all 51 research articles in the most accessible manner to discuss the Genetic pathway, Staging, Histopathology, Clinical features, Diagnostic Imaging, Treatment, and Management. Results-Iris melanomas are discovered early and treated fast because they are apparent when they are little. As a result, patients with this tumor had a better prognosis than those with posterior uvea tumors. Conclusion- Radiotherapy or surgical resection are usually used in this situation. A combination of radiotherapy and surgery may be employed in some circumstances. Conservative treatment is an excellent option for enucleation since it provides for effective tumor control locally. Keywords:melanoma, Diagnosis, Management, Stages, Eye-care.

show abstract

“…A study of scleral contact lens (ScCL) wearers demonstrates that repeated use of ScCL can cause vascular alterations in conjunctiva detected by AS-OCTA ( 48 ). Recent research shows that AS-OCTA works best on superficial and non-pigmented conjunctiva lesions, and malignant lesions always accompanied by deeper and larger perilesional vessels, which could be a significant marker of clinical diagnosis ( 49 , 50 ).…”

Section: As-octa Precise Diagnosismentioning

confidence: 99%

Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Luo

Zhuo

2021

Front. Med.

View full text Add to dashboard Cite

Optical coherence tomography angiography (OCTA) is the most relevant evolution based on optical coherence tomography (OCT). OCTA can present ocular vasculature, show detailed morphology for assessment, and quantify vessel parameters without intravenous dye agent. Research on the anterior segment OCTA (AS-OCTA) is only in its initial phase, and its advances in clinical diagnosis and treatment efficacy evaluations require a detailed comparison to traditional imaging methods. In this review of AS-OCTA, we summarize its technical features, imaging advances, current clinical applications in various eye diseases, as well as its limitations and potential future directions. AS-OCTA offers potential advantages in ophthalmic imaging, and with further development it could become a common tool in the near future.

show abstract

Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris

Cited by 25 publications

References 43 publications

Case Series: Different Presentations of Iris Melanoma—Potential Masquerade of Benign and Malignant

Case Series: Different Presentations of Iris Melanoma—Potential Masquerade of Benign and Malignant

Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management

Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography

Contact Info

Product

Resources

About