Anthelmintic activities of chloroform and methanol extracts of Buchholzia coriacea Engler seed

Abstract

The anthelmintic potentials of the chloroform and methanol extracts of Buchholzia coriacea Engler seed were investigated. In folklore medicine, B. coriacea (Capparidaceae) is believed to be useful in the treatment of various kinds of ailments and diseases. At doses of 10 mg/kg, 25 mg/kg and 50 mg/kg, the extracts were tested against Eudrilus eugeniae (earthworm) and Bunostomum phlebotomum (cattle hookworm). The extracts exhibited dose-dependent anthelmintic effects on the earthworms and hookworms. The methanol extract at 50 mg/kg was the most active extract against the helminths, and the activity of the methanol extract was not significantly different from that of piperazine hydrate (reference drug, 10 mg/kg) against the earthworms.

In vitro anthelmintic activity of Zanthoxylum simulans essential oil against Haemonchus contortus

“…However, commercially available anthelmintic agents in developing countries are unaffordable; in addition, these agents and their secondary metabolites pose a threat to human health (Cabaret, 2008). These issues reinforced the need to derive safe and cheap anthelmintic agents from plants (Fred-Jaiyesimi et al, 2011). Although Zanthoxylum is a known potential source of anthelmintic agents for traditional Chinese medicine, only a few studies have assessed the anthelmintic activity of Zanthoxylum species (Olounlade et al, 2012).…”

Anti-Diabetic Property and Phytochemical Composition of Aqueous and Methanol Extracts of Buchholzia coriacea Seeds in Alloxan-Induced Diabetic Rats

“…Previous phytochemical analysis has reported the presence of alkaloids, saponins, cardiac glycosides and flavones glycosides (Adisa et al, 2011). Saponins, anthraquinones, alkaloids, cyanogenic glycosides have been observed by Fred-Jaiyesimi et al (2011). Tannins and cardiac glycosides were also reported by Mbata et al (2009) in the seeds of Buchholzia coriacea.…”

Antioxidant and antihypertensive activities of wonderful cola ( Buchholzia coriacea) seed protein and enzymatic protein hydrolysates

“…Although the seed has a low protein content of 13% (Ezekiel and Onyeoziri, 2009), its use in hypertension management has been reported (Adisa et al, 2010). Besides, several studies have also reported other health benefits of the seeds (Fred-Jaiyesimi et al, 2011;Adisa et al, 2010;Ezekiel and Onyeoziri, 2009;Ajaiyeoba et al, 2001). However, information is lacking on the specific wonderful cola compounds (proteins, polyphenols, polysaccharides, etc) that are responsible for these bioactivities.…”