Anthelmintic efficacy and dose determination of Albizia anthelmintica against gastrointestinal nematodes in naturally infected Ugandan sheep

Gradé, Jeanne; Arble, Bennett L.; Weladji, Robert B.; Damme, Patrick Van

doi:10.1016/j.vetpar.2008.07.021

Cited by 25 publications

(13 citation statements)

References 27 publications

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“…Natural plant-derived products have been known for many decades to possess anthelmintic properties [5,6] and yet generally these have been inadequately researched and none have been taken to the market stage. One such group of potential anthelmintics is the cysteine proteinases found in fruits such as papaya, figs, kiwi fruits and pineapples.…”

Section: Introductionmentioning

confidence: 99%

Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus

et al. 2011

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BackgroundThe cysteine proteinases in papaya latex have been shown to have potent anthelmintic properties in monogastric hosts such as rodents, pigs and humans, but this has not been demonstrated in ruminants.MethodsIn two experiments, sheep were infected concurrently with 5,000 infective larvae of Haemonchus contortus and 10,000 infective larvae of Trichostrongylus colubriformis and were then treated with the supernatant from a suspension of papaya latex from day 28 to day 32 post-infection. Faecal egg counts were monitored from a week before treatment until the end of the experiment and worm burdens were assessed on day 35 post-infection.ResultsWe found that the soluble fraction of papaya latex had a potent in vivo effect on the abomasal nematode H. contortus, but not on the small intestinal nematode T. colubriformis. This effect was dose-dependent and at tolerated levels of gavage with papaya latex (117 μmol of active papaya latex supernatant for 4 days), the H. contortus worm burdens were reduced by 98%. Repeated treatment, daily for 4 days, was more effective than a single dose, but efficacy was not enhanced by concurrent treatment with the antacid cimetidine.ConclusionsOur results provide support for the idea that cysteine proteinases derived from papaya latex may be developed into novel anthelmintics for the treatment of lumenal stages of gastro-intestinal nematode infections in sheep, particularly those parasitizing the abomasum.

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Section: Introductionmentioning

confidence: 99%

Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus

et al. 2011

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“…The anthelmintic activity of powdered bark of Albizia anthelmintica (Brongn. ), given orally, to naturally infected sheep was demonstrated, with fecal egg count reductions varying from 66.5 to 78.3% [80] . A dose-dependent anthelmintic effect of a mixture of different aboveground parts (except thorns) of Cereus jamacaru (P.D.C.)…”

Section: Reports Of Anthelmintic Efficacy Of Phytotherapic Substancesmentioning

confidence: 97%

Plants and their medicinal potential for controling gastrointestinal nematodes in ruminants

Borges¹,

Borges²

2016

Nematoda

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HIGHLIGHTS• Plants with anthelmintic activity may have potential sources of chemical substances that can be used to control gastrointestinal nematodes in ruminants.• The main difficulty of the research with herbal medicines is the lack of in vitro and in vivo correlation with phytotherapic substances activities.• Better understanding the interactions between metabolites and the use of appropriate methodologies to evaluate phytotherapics, may contribute to in vivo results. ABSTRACT:Gastrointestinal nematodes (GINs) is one of the main sanitary problems of ruminant herds, causing large economic losses to breeders. Chemical control continues to be the main measure used to combat GINs, but as resistant parasite populations spread, the efficiency of this method is becoming impaired. In light of this situation, alternative ways to control verminosis are gaining importance. Among these, phytotherapy has attracted particular attention. This review presents the current status of research on phytotherapeutic agents, their difficulties and perspectives. Plants with nematicidal activity are a potential source of chemical substances, including new molecules, that can be used to control GINs in ruminants. The principal difficulty of research into phytotherapic substances is to identify the bioactive compounds, because in many cases in vitro tests have shown promising results, but in vivo test results have been disappointing. Among the causes is host-drug interaction. Therefore, more careful choice of plants with anthelmintic potential by adoption of a standardized system to analyze the results of in vitro testing, combined with better understanding of the synergistic relations among metabolites and the adjustment of methods for in vivo testing, can make phytotherapy for control of GINs more effective.

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“…Because of the great potential of medicinal plants in the manufacturing of antimicrobial drugs, this study screened the plant species Albizia anthelmintica for the antibacterial and antifungal activity of its extracts. A. anthelmintica belongs to the kingdom Plantae (Order Fabales; family Fabaceae; subfamily Mimosoideae) (Grade et al, 2008). Albizia species have high content of phenolic compounds such as triterpenoids and saponins.…”

Section: Introductionmentioning

confidence: 99%

“…In Africa, Albizia plant species are commonly used in the treatment of conditions such as diarrhea, coughs and rheumatism. Plants such as these have proved crucial to Wale et al 457 the identification of novel agents of therapy (Grade et al, 2008). The study aimed to determine the antibacterial potential of A. anthelmintica as a medicinal plant on pathogenic veterinary isolates.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolates

Wale¹,

Kwape²,

Sethibe³

et al. 2018

J. Med. Plants Res.

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Albizia anthelmintica is a medicinal plant belonging to the Fabaceae family. It is widely used by smallholder farmers and pastoralists to treat internal parasites in their livestock. This study aimed to determine the antibacterial and antioxidant potential of A. anthelmintica on pathogenic veterinary isolates. 100% hexane (He100), 100% chloroform (Ch100), 100% ethanol (E100), and 70% ethanol (E70) extracts of the roots and barks of A. anthelmintica were tested against four bacterial strains (Escherichia coli, Clostridium perfringens, Salmonella enterica serovar Typhimurium and Proteus mirabilis). Thin layer chromatography-2, 2-diphenyl-1-picryl hydrazyl (TLC-DPPH) assay was used to examine antioxidant potential of extracts. Antimicrobial activity was determined using the disc diffusion method and minimum inhibiting concentrations (MICs) values were determined using the micro-titre broth-dilution method. At a concentration of 500 µg/ml, E70 roots extract showed the highest % DPPH inhibition of 66.9%. Among the bark extracts, the highest free radical scavenging activity was observed in E70 extracts with 58.9% DPPH inhibition. Phytochemical analysis of the plant extracts revealed the presence of compounds which are known to exhibit medicinal properties such as tannins, terpenoids, quinones, saponins and fatty acids phenols. E100 bark extracts contained most of these compounds except flavonoids. Only alkaloids were not detected in any of the roots or bark extracts. Ch100 bark extracts showed the highest antimicrobial activity and all bacterial isolates were resistant to the E100 root extracts. Ch100 root extracts showed the lowest minimum inhibition concentration of 0.625 mg/ml against S. enterica serovar Typhimurium. Findings of this study show that some of the root and bark extracts of the A. anthelmintica plant have both antimicrobial and antioxidant properties. These findings can possibly be relevant in the development of novel medication against veterinary pathogens. Furthermore, this study will guide similar studies.

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Anthelmintic efficacy and dose determination of Albizia anthelmintica against gastrointestinal nematodes in naturally infected Ugandan sheep

Cited by 25 publications

References 27 publications

Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus

Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus

Plants and their medicinal potential for controling gastrointestinal nematodes in ruminants

Antibacterial and antioxidant potential of Albizia anthelmintica as a medicinal plant on pathogenic veterinary isolates

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