Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control

Holsback, Luciane; Luppi, Pedro Alex Ramsey; Silva, Camile Sanches; Negrão, Gustavo Kremer; Conde, Gabriel; Gabriel, Hugo Vinícius; Balestrieri, João Vitor; Tomazella, Lucas

doi:10.1590/s1984-29612016025

Cited by 12 publications

(11 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The efficacies were categorized as: highly effective when Efficacy % > 98%; effective when 90-98%; moderately effective 80-89%; and insufficiently effective < 80% (Ordination 79/1996MERCOSUL, GMC, 1996: In Holsback et al 2016.…”

Section: Discussionmentioning

confidence: 99%

A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite “Psoroptes cuniculi”

Elhawary

Sorour

El-Abasy

et al. 2017

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

The ear mite "Psoroptes cuniculi" is the main cause of ear mange, a highly contagious parasitic skin disease in rabbits all over the world. In the current work, a preliminary therapeutic trial to study the effect of the broad use acaricides doramectin and ivermectin on P. cuniculi was performed on artificially infested rabbits.Twenty five adult New Zealand white rabbits were used in this study. The rabbits were assigned randomly into five groups/ 5 rabbits in each group. Each rabbit was experimentally infested with 100 mites/ ear. The first group was designated the positive control group and was not treated. The second and third groups were treated with doramectin 200 and 400 μg/kg bw, respectively. Groups 4 and 5 were treated by dressing with ivermectin in one dose and 2 doses with a 1 week interval. After the therapy, all rabbits were examined microscopically on the 7 th , 14 th , and 28 th day post treatment and the number of live mites (larvae, nymphs, and adults) on each rabbit was counted at the end of the experiment (28 th day).The results showed that the rabbits treated subcutaneously with doramectin at a single dose of 200 μg /kg bw showed a very low effect, although there was significant improvement when the dose was doubled to 400 μg /kg bw, with the number of mites counted decreasing significantly. Rabbits treated topically with ivermectin spot-on, a single dose or 2 doses, showed great improvement of the lesion: the number of mites was reduced to zero. In conclusion, this work showed that ivermectin spot-on applied locally on infested ears proves to be more effective against P. cuniculi than doramectin injected subcutaneously. Further trials on ear mange therapeutics in rabbits are to be encouraged.

show abstract

Section: Discussionmentioning

confidence: 99%

A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite “Psoroptes cuniculi”

Elhawary

Sorour

El-Abasy

et al. 2017

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…A similar situation exists for domestic livestock, a problem in developing and developed regions of the world, where infection with helminth parasites takes a tremendous toll on productivity (e.g., meat yields), 11 and resistance to anthelminthics is increasing alarmingly. 12 Thus, while helminth biology may be unfamiliar to the reader, helminths are a ubiquitous component of our ecosystem.…”

Section: Helminth Parasitesmentioning

confidence: 99%

Helminths and intestinal barrier function

2017

View full text Add to dashboard Cite

Approximately one-sixth of the worlds' population is infected with helminths and this class of parasite takes a major toll on domestic livestock. The majority of species of parasitic helminth that infect mammals live in the gut (the only niche for tapeworms) where they contact the hosts' epithelial cells. Here, the helminth-intestinal epithelial interface is reviewed in terms of the impact on, and regulation of epithelial barrier function, both intrinsic (epithelial permeability) and extrinsic (mucin, bacterial peptides, commensal bacteria) elements of the barrier. The data available on direct effects of helminths on epithelial permeability are scant, fragmentary and pales in comparison with knowledge of mobilization of immune reactions and effector cells in response to helminth parasites and how these impact intestinal barrier function. The interaction of helminth-host and helminthhost-bacteria is an important determinant of gut form and function and precisely defining these interactions will radically alter our understanding of normal gut physiology and pathophysiological reactions, revealing new approaches to infection with parasitic helminths, bacterial pathogens and idiopathic auto-inflammatory disease.

show abstract

“…Epidemiological studies of parasitic diseases in the North Pioneer mesoregion are scarce. However, the few studies on ruminants in this region have shown high parasite loads, which may reflect poor sanitary conditions and inadequate handling of these animals (HOLSBACK et al, 2013(HOLSBACK et al, , 2015(HOLSBACK et al, , 2016.…”

Section: Introductionmentioning

confidence: 99%

Cryptosporidium occurrence in ruminants from the North Pioneer mesoregion of Paraná, Brazil

Holsback

Lima

Vidotto

et al. 2018

Rev. Bras. Parasitol. Vet.

Self Cite

View full text Add to dashboard Cite

The aim of this study was to investigate the occurrence of Cryptosporidium in cattle and sheep from the North Pioneer mesoregion of the state of Paraná. For this, 317 stool samples were collected from cattle and sheep on 16 properties in six municipalities in the North Pioneer mesoregion of Paraná. For detection of Cryptosporidium species, molecular analysis was performed using nested-PCR techniques targeting the 18S rRNA gene. Of the 37 beef cows and 115 calves analyzed, four (10.8%) and 14 (12.2%), respectively, were positive for Cryptosporidium. Of the 12 cows and 52 calves, one (8.3%) and 14 (26.9%), respectively, were positive for Cryptosporidium; and of the 42 ewes and 59 lambs, six (14.3%) and 12 (20.3%), respectively were positive for Cryptosporidium. Cattle (15.3%) and sheep (17.8%) were both susceptible to infection. All the properties of the municipalities of Assaí, Ibaiti and, Leópolis presented infected animals. The study showed that Cryptosporidium occurs in most municipalities assessed, that dairy calves had a higher risk (Odds Ratio=2,66, p-value=0,018) for infection than beef calves, and that sheep are just as susceptible to infection as are cattle, and that further Cryptosporidium studies are developed.

show abstract

Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control

Cited by 12 publications

References 27 publications

A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite “Psoroptes cuniculi”

A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite “Psoroptes cuniculi”

Helminths and intestinal barrier function

Cryptosporidium occurrence in ruminants from the North Pioneer mesoregion of Paraná, Brazil

Contact Info

Product

Resources

About