“…The antihistamine experiments demonstrated the efficacy of these drugs in neutralizing insulin allergic effects: this has been confirmed by therapeutic experience, sometimes combined with desensitization, spontaneous or induced (Hunter and Hill, 1947;Leavitt and Gastineau, 1947;Armstrong and Lloyd, 1954). In the treatment of the above case an oral antihistamine was used, but it may be that early administration of an injectable compound, unfortunately not available at the time, might have shortened the emergency period.…”