Anthocyanin Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies

Wang, Xin; Yang, Deyi; Yang, Liuqing; Zhao, Wenzhi; Cai, Li-Ya; Shi, Hanping

doi:10.1080/07315724.2018.1531084

Cited by 42 publications

(37 citation statements)

References 48 publications

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“…The previous SR-MAs for anthocyanins reported on dyslipidemia [ 28 ], vascular inflammation [ 29 ], lipid composition and inflammation [ 30 ], heart disease [ 31 ], hypertension [ 32 , 33 , 34 ], DM [ 35 ], and antioxidation [ 36 ]. Thus far, only a few have been conducted on obesity-related studies for the anti-obesity effect of a flavanol complex [ 36 ] and the weight-reducing effect of resveratrol (400–800 mg/day, 1–24 weeks) [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021

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Anthocyanins, water-soluble flavonoids that produce red-to-blue pigment in plants, have antioxidant properties and have been developed as a functional food to fight obesity. In randomized controlled trials (RCTs), a systematic review with meta-analysis (SR-MA) was used to investigate these anti-obesity effects. Using search engines (PubMed, EMBASE, Cochrane-library, and CINAHL) and keywords (anthocyanins, BMI, WC, WHR, and inflammatory biomarkers), 11 out of 642 RCTs (28.3–500 mg/day of anthocyanins for 4 to 24 weeks) were included. The results showed a significant reduction in body mass index (BMI) (MD = −0.36, 95% CI = −0.58 to −0.13), but body weight (BW) and waist circumference (WC) did not change. Anthocyanins decreased BMI in the non-obese (non-OB) group in five RCTs (BMI ≤ 25; MD = −0.40 kg/m2; 95% CI = −0.64 to −0.16;) but did not affect BMI in the obese (OB) group. A subgroup analysis of six RCTs showed that fewer than 300 mg/day reduced BMI (MD = −0.37; 95% CI = −0.06 to −0.14), but ≥300 mg/day did not. A treatment duration of four weeks for four RCTs was sufficient to decrease the BMI (MD = −0.41; 95% CI = −0.66 to −0.16) as opposed to a longer treatment (6–8 or ≥12 weeks). An analysis of the effect of anthocyanins on the BMI showed a significant fall among those from the Middle East compared to those from Asia, Europe, South America, or Oceania. In conclusion, the anthocyanin supplementation of 300 mg/day or less for four weeks was sufficient to reduce the BMI and BW compared to the higher-dose and longer-treatment RCTs. However, further studies might be conducted regarding the dose- or period-dependent responses on various obese biomarkers.

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Section: Discussionmentioning

confidence: 99%

Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021

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“…Anthocyanins, which are widely distributed in edible plants, are a benefit to health [ 19 – 21 ]. For instance, anthocyanins have an effective function in neurological diseases, hypoglycemia, cardiotoxicity, and anti-inflammation [ 22 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Delphinidin on Oxidative Stress Induced by H2O2 in HepG2 Cells

Zhang

Ren

et al. 2020

Oxidative Medicine and Cellular Longevity

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Chronic liver diseases (CLDs) are correlated with oxidative stress induced by the accumulation of intracellular reactive oxygen species (ROS). In this study, we employed HepG2, a human liver carcinoma cell line containing many antioxidant enzymes, to explore the function of delphinidin against oxidative stress induced by H2O2 and to provide scientific data of the molecular mechanism. Cells were pretreated with different concentrations of delphinidin (10 μmol/L, 20 μmol/L, and 40 μmol/L) for 2 h before treatment with 750 μM H2O2 for 1 h. The results showed that H2O2 decreased the survival rate of HepG2 cells and increased the level of ROS, but delphinidin pretreatment could possess the opposite result. At the same time, the expression of Nrf2 was enhanced by the delphinidin pretreatment. This was because delphinidin promoted Nrf2 nuclear translocation and inhibited its degradation, which led to the increase expression of antioxidant protein HO-1 (Nrf2-related phase II enzyme heme oxygenase-1). Besides, we found that delphinidin could significantly alleviate the reduction of Nrf2 protein levels and the accumulation of intracellular ROS levels in Nrf2 knockdown HepG2 cells. In conclusion, our study suggested that delphinidin, as an effective antioxidant, protected HepG2 cells from oxidative stress by regulating the expression of Nrf2/HO-1.

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“…There are many studies have been done to access the effect of anthocyanin on CRC prevention both in-vitro and in-vivo. Moreover, recent meta-analysis revealed the inverse association between anthocyanin consumption and the colorectal cancer incidence [28]. As Fernández et al [29] revealed, Rattus norvegicus (F 344 ) rats who received two doses of (AOM) (10 mg/kg) and fed with functional sausages containing 0.1% (w/w) of anthocyanin from a mixture of dehydrated blackberries and strawberries for 20 weeks displayed less tumor number, size, and progression.…”

Section: Colorectal Cancermentioning

confidence: 99%

Dietary Anthocyanins- Smart Molecules with Chemo Preventive and Chemotherapeutic Activity

Surangi

2020

OMCIJ

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Anthocyanin Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies

Cited by 42 publications

References 48 publications

Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Anthocyanin Supplementation on Reduction of Obesity Criteria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Inhibitory Effect of Delphinidin on Oxidative Stress Induced by H2O2 in HepG2 Cells

Dietary Anthocyanins- Smart Molecules with Chemo Preventive and Chemotherapeutic Activity

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