Anti-aging Effect of Inula britannica var. chinensis Flower Extract According to the Extraction Temperature

전지민,; 유대성,; 천종우,; 권순식,; 전소하,; 박수남,

doi:10.15230/scsk.2014.40.1.109

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…However, the UE showed the lowest cell cytotoxicity of 12.50%, possibly because the low-temperature process could minimize the generation of toxic substances during the extraction process, especially for marine bioresources. Similar patterns have been found in extracting medicinal plants, which are generally more stable in heating processes than marine biomass [ 22 ].…”

Section: Resultssupporting

confidence: 70%

Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process

Kim

Choi

Heo

et al. 2017

Journal of Healthcare Engineering

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Objectives This work aimed to enhance anti-skin cancer activities of Apostichopus japonicus, spiky sea cucumber, through ultrasonification extraction process at low temperature. Methods Dried Apostichopus japonicus was extracted with an ultrasonification process at 50°C and 95 kHz for two hours (UE), and anti-skin cancer activities of the extract from the UE were also compared with those from conventional extraction processes using hot water (WE) or 70% ethanol at 80°C (EE) for 12 hours. Results The amount of canthaxanthin in the UE was higher than that in the WE or EE, and its cytotoxicity against human keratinocytes was less than the others. The extract from the UE showed 93.5% inhibition against human malignant cell growth, which was also higher than those from both WE and EE. The extract from the UE demonstrated the ability of inhibiting both cancer cell proliferation and metastasis by downregulating the skin tumor-promoting genes such as Bcl-2, STAT3, and MMP-9. Conclusions The ultrasonification process was proved to be effective especially in extracting heat-sensitive marine biomass, A. japonicus having higher amounts of canthaxanthin and better anti-skin cancer activities, possibly due to less destruction and high elution of bioactive substances under low temperature extraction condition.

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Section: Resultssupporting

confidence: 70%

Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process

Kim

Choi

Heo

et al. 2017

Journal of Healthcare Engineering

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“…Extracts of I. britannica flowers can be used in cosmetic products [36] to take advantage of the skin anti-inflammatory, antioxidant, antibacterial and anti-aging properties of the extract [37][38][39]. A methanol extract of the dried flower of I. britannica L. has been shown to suppress the expression of the tyrosinase enzyme implicated in melanin synthesis.…”

Section: Inula Species Producing Brt and Their Medicinal Usesmentioning

confidence: 99%

Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones

Bailly

2021

Biomedicines

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Sesquiterpene lactones (SLs) are abundant in plants and display a large spectrum of bioactivities. The compound britannin (BRT), found in different Inula species, is a pseudoguaianolide-type SL equipped with a typical and highly reactive α-methylene-γ-lactone moiety. The bioproperties of BRT and related pseudoguaianolide SLs, including helenalin, gaillardin, bigelovin and others, have been reviewed. Marked anticancer activities of BRT have been evidenced in vitro and in vivo with different tumor models. Three main mechanisms are implicated: (i) interference with the NFκB/ROS pathway, a mechanism common to many other SL monomers and dimers; (ii) blockade of the Keap1-Nrf2 pathway, with a covalent binding to a cysteine residue of Keap1 via the reactive α-methylene unit of BRT; (iii) a modulation of the c-Myc/HIF-1α signaling axis leading to a downregulation of the PD-1/PD-L1 immune checkpoint and activation of cytotoxic T lymphocytes. The non-specific reactivity of the α-methylene-γ-lactone moiety with the sulfhydryl groups of proteins is discussed. Options to reduce or abolish this reactivity have been proposed. Emphasis is placed on the capacity of BRT to modulate the tumor microenvironment and the immune-modulatory action of the natural product. The present review recapitulates the anticancer effects of BRT, some central concerns with SLs and discusses the implication of the PD1/PD-L1 checkpoint in its antitumor action.

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“…피부는 전신을 둘러싸며 외부로부터 여러 가지 자극 및 장해, 혹은 건조로부터 생체를 보호하는 역할을 하고 있다 (Jeon et al, 2014 (Kim et al, 2013 (Jang et al, 2015;Yoo et al, 2013 (Moon & Lee, 1997).…”

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Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients

Yu¹,

Kim²

2017

Asian J Beauty Cosmetol

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Purpose: This study confirms the cosmeceutical effects of the Lindera obtusiloba (L. obtusiloba) flower and its applicability as a natural cosmetic ingredient. Methods: After obtaining the extracts from the L. obtusiloba flower using hot water and 70% ethanol, its anti-oxidation, whitening, wrinkle improvement, and anti-bacterial properties were measured. Results: The ethanol extracts from the L. obtusiloba flower had a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects of 81.33% at 500 µg/mL and contained phenol and flavonoid concentrations of 152.00 and 145.27 µg/mL, respectively, which were higher than those seen in the hot water extracts. With respect to the whitening effects of the L. obtusiloba flower, the ethanol extracts suppressed tyrosinase enzyme activity by 31.00% at a concentration of 500 µg/mL. In B16F10 melanoma cells, the extracts showed excellent inhibitory effects on tyrosinase and melanin biosynthesis. Its inhibitory effects on α-melanocyte-stimulating hormone (α-MSH)-induced tyrosinase activity and melanin biosynthesis were higher than those observed using the positive control, arbutin. The measurement of procollagen synthesis confirmed the wrinkle improvement effects of the L. obtusiloba flower, with the ethanol extracts promoting a 130.00% increase in procollagen biosynthesis. The anti-bacterial effects of the L. obtusiloba flower extracts on Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), and Propionibacterium acnes (P. acnes) were assessed. Here the ethanol extracts had the greatest anti-bacterial effects on S. epidermidis and P. acnes. Conclusion: L. obtusiloba flower extracts are expected to be highly applicable as natural functional cosmetics of material having skin whitening, wrinkle improvement, and anti-bacterial effects.

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Anti-aging Effect of Inula britannica var. chinensis Flower Extract According to the Extraction Temperature

Cited by 5 publications

References 17 publications

Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process

Anti-Skin Cancer Activities of Apostichopus japonicus Extracts from Low-Temperature Ultrasonification Process

Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones

Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients

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