Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model

Abstract

Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. The Korean herbal medicine, So-Cheong-Ryong-Tang (SCRT) has been typically used for the treatment of AR for hundreds of years. In the present study, we investigated whether SCRT suppresses the progression of AR in animal model. AR was induced by ovalbumin (OVA). Treatment with SCRT was assessed to study the effect of SCRT on AR in mice. Histological analysis, multiplex cytokine assay, blood analysis, cell viability assay, RT-PCR and Elisa assay were performed to verify inhibitory effect of SCRT on AR. SCRT reduced infiltration of inflammatory cells into nasal cavity. SCRT reduced infiltration of mast cells into nasal mucosa. SCRT reduced the levels of cytokines (IL-4 and LIF) in the serum. SCRT reduced the levels of leukocytes in the blood. SCRT decreased cell viability of HMC-1 cells and splenocyte. SCRT suppressed IL-4 level in HMC-1 cells and splenocyte cells in a dose-dependent manner. SCRT suppressed IL-6 level and TNF-α level in splenocyte. SCRT suppresses the progression of AR induced by OVA. SCRT might be a useful drug for the treatment of AR.

So-Cheong-Ryoung-Tang Attenuates Pulmonary Inflammation Induced by Cigarette Smoke in Bronchial Epithelial Cells and Experimental Mice

“…According to the OASIS, this mixture has long been used to treat common cold, bronchitis, and bronchial asthma in the traditional oriental clinic. It is an herbal mixture used to treat various diseases such as allergic rhinitis and asthma ( Yang et al, 2009 ; Wang et al, 2012 ; Kim et al, 2014 ; Ku et al, 2016 ). It was recently shown that So-Cheong-Ryoung-Tang effectively decreased the production of cytokines and chemokines on airway remodeling in allergic asthma model and attenuated allergic effects in a rat model of ovalbumin-induced rhinitis via the phosphatidylinositol 3 kinase (PI3K)/Akt signaling pathway ( Kim et al, 2014 ; Park et al, 2015 ).…”

Efficacy and safety of So-Cheong-Ryong-Tang in treatment of perennial allergic rhinitis: study protocol for a double-blind, randomised, parallel-group, multicentre trial

“…To our knowledge, there exists one randomised clinical trial for SCRT use in patients with AR. 10 However, primary outcome measurement conducted in that study was not suitable to estimate sample size. We applied effect size and SD values obtained from other trials that used herbal medicines in patients with AR.…”

“…SCRT has been observed to regulate cytokines in animal studies. [10][11][12] However, no clinical study has observed the effect of SCRT on cytokine regulation.…”

“…9 In animal studies, SCRT has suppressed the progression of AR and allergic asthma. [10][11][12] A single randomised controlled clinical study was performed in Japan. 13 However, the treatment period for the study was only 2 weeks and there was no follow-up period after the treatment.…”

Tonggyu-tang, a traditional Korean medicine, suppresses pro-inflammatory cytokine production through inhibition of MAPK and NF-κB activation in human mast cells and keratinocytes

“…In traditional Korean Medicine, several herbal medicines have been used for the treatment of allergic inflammation. Especially, Tonggyu-tang (TGT) composed of 12 herbs (Table 1), similarly Pyeongwee-San [7], Biyeom-Tang [8], Hyeonggaeyeongyo-Tang [9] and So-Cheon-Ryon-Tang [10] have shown anti-inflammatory effects on patients with allergic nasal disorder.…”