Anti-angiogenic activity ofMorinda citrifoliaextracts and its chemical constituents

Abstract

Morinda citrifolia L. has been used for the treatment of a wide variety of diseases, including cancer. This study was undertaken to evaluate the anti-angiogenic effect of M. citrifolia fruits and leaves. Anti-angiogenic activity was evaluated in vivo using the chick chorioallantoic membrane assay. Bioactivity-guided fractionation and isolation were performed to identify the active constituent, and high-performance liquid chromatography analysis was then used to quantify the amount of this active constituent in the active extracts and fraction. The methanol extracts of fruits and leaves of M. citrifolia and the subsequent chloroform fraction of the fruit methanolic extract were found to have potential anti-angiogenic activity and were more potent compared to suramin. Scopoletin was identified as one of the chemical constituents that may be partly responsible for the anti-angiogenic activity of M. citrifolia fruits. The present findings further support the use of M. citrifolia in cancer or other pathological conditions related to angiogenesis.

Morinda citrifolia leaf enhanced performance by improving angiogenesis, mitochondrial biogenesis, antioxidant, anti-inflammatory & stress responses

“…4). Many anti-angiogenic reports on Morinda citrifolia were based on the fruit and none were done on the leaf under exercise training conditions (Beh et al, 2012;Jang, 2012). The Morinda leaf was anti-angiogenic under lung cancer metastasis conditions (Lim, Mustapha, Goh, Bakar, & Mohamed, 2016).…”

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

“…One factor that determines the action of noni extracts on cancer is its anti‐angiogenic potential. M. citrifolia leaf and fruit methanol extract, as well as the chloroform fraction of fruit extract, exhibit anti‐angiogenic activity in vivo , and this effect is in part attributed to scopoletin, a chemical compound found in the plant (Beh et al , ).…”

The Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay

“…L extracts possess anti-angiogenic activity using CAM assay. 17 In addition, it also has almost same ability to inhibit the blood vessel like Bevacizumab drugs. A previous study by Piaru et al has showed that Morinda citrifolia L. oil have a tendency to reduce the growth of the blood vessel in anti-angiogenic effect using ex-vivo on rat aortic rings.…”