Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum

Song, Yun Seon; Kim, Sun-Hyoung; Sa, Jae-Hoon; Jin, Changbae; Lim, Chang‐Jin; Park, Eun-Hee

doi:10.1016/j.jep.2003.09.006

Cited by 73 publications

(43 citation statements)

References 20 publications

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“…According to the Song, et al, Ganoderma lucidum PsP has the ability to stimulate the body's immune response and have the effect of anti-angiogenesis and anti-tumor if given in pathologic conditions. (17) Research by Chen, et al, and Jia, et al, also support the statement that Ganoderma lucidum PsP lipid peroxidation and blood glucose levels in diabetic model rats. (10,18) Other studies by Menget, et al, states that Ganoderma lucidum PsP has the potential in the treatment of myocardial fibrosis with lower accumulation of collagen levels through the decrease of total hydroxyproline on the myocardium of the ventricles of the rat heart.…”

Section: Discussionmentioning

confidence: 77%

The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

et al. 2017

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B ACKGROUND: Type 2 Diabetes Mellitus (DM)is one of dominant factors in cardiovascular deaths and induces endothelial dysfunction. A definite sign of endothelial dysfunction is foam cells formation derived from oxidized LDL. This study was conducted to determine the effect of Polysaccharides Peptides (PsP) Ganoderma lucidum to foam cell counts and lipid profile in diabetic model rats with high-fat diet. METHODS:Treatment group was categorized to negative control, positive control, DM-50, DM-150, and DM-300. Type 2 DM induced by Streptozotocin. PsP was administered with predetermined doses on each treatment's group (50, 150 and 300 mg/kgBW) for 12 weeks. Measurements of foam cell count were held after obtaining rat's aorta. To assess lipid profile, blood sample was taken from the rat's heart. The data were analyzed by One-way ANOVA and Post Hoc Tukey tests. RESULTS:The administration of Ganoderma lucidum PsP to diabetic model rats provided a significant difference in lowering foam cell (p=0.017; CI 95%). It also gave significant difference between levels of each lipid components (Total Cholesterol, Trygliceride, LDL and HDL) in at least two treatment groups (p=0.010; CI 95%). Based on Post Hoc Tukey tests, the relationship between administration of PsP and foam cell is significant (p=0.002). CONCLUSION:PsP has antioxidant and anti-inflammatory effect in type 2 DM model Rattus norvegicus strain Wistar, which can inhibit atherosclerosis and endothelial damage process. Further studies are necessary to evaluate the benefits of PsP as an adjuvant therapy in the management of diabetic dyslipidemia. KEYWORDS:

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Section: Discussionmentioning

confidence: 77%

The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

et al. 2017

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“…The fungus was used to prevent or as therapeutic treatment of various diseases such as arthritis, cancer, chronic hepatitis, hepatopathy, hypertension, and many other diseases and pathologies [58,59]. Indeed, it was clear that these beneficial effects on health and diseases prevention are mainly due to the bioactive compounds including the polysaccharides and terpenoids of the fungus.…”

Section: Mechanisms Of Action Of G Lucidum Polysaccharides and Terpenmentioning

confidence: 99%

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Benkeblia¹

2016

J Food Nutri Diete

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Recent studies have shown that mushrooms are recognized as a promising source of functional and nutraceutical compounds. The species Ganoderma lucidum (also called Reishi or Lingzhi) is a mushroom used in medicine because Chinese attributes to this fungus better health and longevity. Among the numerous bioactive compounds identified in G. lucidum are polysaccharides mostly β-glucans, heteropolysaccharides or glycoproteins, terpenoids mostly ganoderic acids and derivatives, as well as many other bioactive proteinases that contribute to health and diseases prevention. The aim of this review is to report on the profile of the most bioactive compounds, particularly polysaccharides and terpenoids of G. lucidum.

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“…A water extract of mycelia has also been assessed for cardiovascular activity in rabbits and rats, and was found to decrease systolic and diastolic blood pressure (29). Cao and Lin observed that Ganoderma lucidum polysaccharides and peptide inhibited in vivo angiogenesis using the chick chorioallantoic membrane assay (9,30).…”

Section: Mak -------------------------------------------------mentioning

confidence: 99%

“…Water or alcohol extracts of Ganoderma lucidum have been used to investigate biological activities, as these extracts contain compounds with immunological and anti-inflammatory properties. Of particular interest among the reported biological/pharmacological properties of Ganoderma lucidum are their anti-tumor activities, including cell cycle arrest, apoptosis induction, motility inhibition, antiangiogenesis, and antimutagenesis (3,(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats

Kashimoto

Hayama²,

Kamiya³

et al. 2006

Oncol Rep

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Abstract.A water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia (MAK) has been shown to exert a potent chemopreventive effect. The present study was designed to investigate the effects of dietary MAK supplementation on the development of lung tumors initiated by N-nitrosobis (2-hydroxypropyl) amine (BHP) in male Slc:Wistar rats. A total of 77 animals, 6 weeks of age, were divided into 5 groups and given BHP (2,000 ppm) in their drinking water for 10 weeks. The normal controls were not supplied with BHP. After treatment with the carcinogen, the rats were fed a normal control MF solid diet, or the same diet containing MAK (1.25%, 2.5% or 5%) for 12 weeks. Macroscopically, all the doses of MAK reduced the number of nodules, and the effect of 5% MAK was found to be especially significant. Microscopically, an increase in the number of proliferating cell nuclear antigen (PCNA)-negative tumors and a decrease in the number of tumors strongly positive for PCNA were observed in the tissue sections from the rats that had received all the doses of MAK. The present results thus indicate that dietary supplementation with MAK inhibits the development of lung tumors, suggesting that MAK may be a potent chemopreventive agent against lung carcinogenesis.

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Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum

Cited by 73 publications

References 20 publications

The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

The Effect of Polysaccharides Peptides Ganoderma Lucidum to Aortic Foam Cell Count and Lipid Profile in Type 2 Diabetic Model Rattus Norvegicus Strain Wistar

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats

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