Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson's Rat model

Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice

“…Antioxidant efficacy of piperine is reported in rats with high fat diet induced oxidative stress (Vijayakumar et al, 2004). It's anti-apoptotic and anti-inflammatory effect has been reported (Shrivastava et al, 2013). Piperine also increases bioactivity of Amaranthus roxburghianus (Nirmal et al, 2013) and in form of reconstituted polyphenol oil bodies for treatment of acute intestinal inflammation (Cavalcanti et al, 2014).…”

Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the Parkinson's disease model in rats

“…Others [29] also demonstrated that PIP reduced contralateral rotations induced by apomorphine, in the same experimental model. A similar effect was observed with alkaloids from Piper longum, including piperine, in a MPTP model of PD in mice, where these compounds increased their movements, as related to the untreated MPTP animals [30].…”

“…In a recent study [29], PIP was shown to reduce lipid peroxidation and to stimulate glutathione levels, in the striatum from rats submitted to 6-OHDA-induced Parkinson's disease. In addition, PIP decreased cytochrome c release from mitochondria and also caspase 3 and 9 activations, besides depleting inflammatory markers as TNF-alpha and IL-1B.…”

Effect of isoflurane�+�N2O inhalation and propofol�+�fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression

“…When the coronary artery or branches have lesions, stenosis or blocking occurs, which causes myocardial ischemic-anoxic injury or necrosis (12). Neither traditional therapy nor newer intervention therapy has been able to achieve satisfactory effects for diffuse injuries of coronary arterioles (13).…”