Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis

Shin, Mi‐Rae; An, Hyo‐Jin; Seo, Bu-Il; Roh, Seong‐Soo

doi:10.3748/wjg.v23.i25.4644

Cited by 6 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, despite their well-known health effects, these therapies could determine the development of severe complications, relapse, and various adverse effects because of the long-term use [ 9 , 10 ]. As an alternative to these problems, in recent years, the development of therapeutic agents using natural materials has been actively conducting [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Lee

Shin

Kim

et al. 2021

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) is induced by the reflux of stomach contents or gastric acid, pepsin into the esophagus for prolonged periods of time due to defection of the lower esophageal sphincter. Reflux esophagitis is a disease found in less than 50% of GERD patients. This study is aimed at evaluating the protective effect of Curcumae longae Rhizoma 30% EtOH extract (CLR) in acute reflux esophagitis (ARE) rats. CLR measured antioxidant activity through in vitro experiments. Based on the results, we performed experiments in vivo. Before 90 min ARE induction, CLR was administered orally by concentration. ARE was derived by linking the metastatic junction between pylorus and forestomach and corpus in Sprague-Dawley rats. And rats were sacrificed 5 h after surgery. We analyzed the expression of antioxidant and inflammatory-related markers by western blot and observed the production of alanine aminotransferase (ALT), aspartate aminotransferase (AST), reactive oxygen species (ROS), peroxynitrite (ONOO-), and thiobarbituric acid reactive substance (TBARS). The administration of CLR reduced esophagus tissue damage in rats with acute reflux esophagitis and decreased the elevated ALT, AST, ROS, ONOO-, and TBARS. In addition, CLR effectively increased antioxidant-related factors and reduced inflammatory protein. Overall, these results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE. Overall, CLR treatment informed that markedly ameliorated inactivation of NF-κB led to the inhibition of the expressions of proinflammatory proteins. These results suggest that CLR would be used as a therapeutic material in protection and treatment for ARE.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Lee

Shin

Kim

et al. 2021

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…The increase in MDA levels, as an indicator of oxidative damage to lipids, has been evidenced in different experimental models of chronic esophagitis [29,42,43], results that are in correspondence with those demonstrated in our study. Therefore, duodenal reflux may act as a co-carcinogen in esophageal squamous cell pathogenesis in rats, which may be mediated by oxidative stress [44].…”

Section: Discussionmentioning

confidence: 99%

Combined Therapy Effect of D-002 and Omeprazole on Chronic Esophagitis Induced by Duodenal Reflux in Rats

Zamora¹,

Mena²,

Molina³

et al. 2018

Journal of Gastroenterology and Metabolism

View full text Add to dashboard Cite

Gastroesophageal reflux disease is a common gastrointestinal disorder. D-002 (beeswax alcohols) and omeprazole (OMP) present protective effects on esophagitis by reflux. In this study, the effect of combined therapy D002 + OMP on duodenum-esophageal reflux (DER) induced-esophagitis in rats was evaluated. Rats were randomized into five groups: one negative control and fourth groups with DER, including a positive control, two with D-002 and OMP (200 and 20 mg/kg, respectively), and other with combination therapy D-002 + OMP (200 + 20 mg/kg, respectively). All treatments were orally administered for 14 days after DER. Esophageal lesions' index (ELI), Histological score (HS) and malondialdehyde (MDA) content in esophagus were determined. Positive controls exhibited increase ELI, HS and MDA in esophagus compared to negative controls. The combination therapy lowered significantly both ELI (48.05%) and MDA (67.8%) compared to positive controls, but without significant differences compared to their respective monotherapies. However, the combination therapy significantly reduced the HS respect to the positive control, reaching 96% inhibition, an effect that was higher than each of the monotherapies. In conclusion, the administration of the combination therapy (D-002 + OMP) represents an additional benefit in the protection of esophageal tissue with respect to treatment with monotherapies.

show abstract

“…Banhasasim-tang (BHS) is a traditional East Asian treatment as decoction including seven herbs. BHS is currently prescribed for the treatment of functional dyspepsia [ 19 , 20 ] and has an antiapoptotic effect on chronic acid reflux esophagitis [ 21 ]. We recently demonstrated that BHS suppresses neuroinflammation in lipopolysaccharide-induced cognitive impairment [ 22 ]; however, the neuroprotective effect of BHS under oxidative stress conditions or its mechanisms are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Banhasasim‐Tang Ameliorates Spatial Memory by Suppressing Oxidative Stress through Regulation of ERK/p38 Signaling in Hippocampus of Mice

Pak

Park

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Since ancient times, Banhasasim-tang (BHS) has been used to treat functional dyspepsia in East Asia. Here, we aimed to determine the protective action of BHS on hippocampal neurons against oxidative stress. We investigated the functional effect of BHS on a scopolamine-induced mouse model, and molecular analysis was performed in glutamate-induced HT22 cells. We observed that BHS administration ameliorated memory dysfunction in scopolamine-treated mice. BHS administration also increased neuronal survival and acetylcholine activity and phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus of mice. In hippocampal cells, BHS treatment rescued glutamate-induced cytotoxicity, apoptosis, and oxidative stress. We observed an increase of HO-1 and a decrease of Nrf2 protein expression in glutamate-induced oxidative stress; however, the expression level of these proteins was significantly rescued by BHS treatment. BHS treatment also regulated phosphorylation of p38, p53, ERK, and CREB. Therefore, our data indicated that BHS may reduce oxidative stress through regulation of ERK-CREB and p38-p53 signaling in the hippocampus, resulting in decreased neuronal damage and improved memory in rodent models of neurodegenerative disease.

show abstract

Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis

Cited by 6 publications

References 37 publications

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Protective Effects of Inflammation of Curcumae Longae Rhizoma 30% EtOH Extract on Acute Reflux Esophagitis Rats

Combined Therapy Effect of D-002 and Omeprazole on Chronic Esophagitis Induced by Duodenal Reflux in Rats

Banhasasim‐Tang Ameliorates Spatial Memory by Suppressing Oxidative Stress through Regulation of ERK/p38 Signaling in Hippocampus of Mice

Contact Info

Product

Resources

About