Anti-Depressant Effect of Ceftriaxone in Forced Swimming Test and in Tail Suspension Test in Mice

Borah, Ajoy; Singha, Binita; Phukan, Swopna

doi:10.22159/ijpps.2016v8i11.14466

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…CEF treated animals also showed a marked decrement of immobility in the forced swim and tail suspension tests. Even though not statistically significant, a similar trend was noted in novelty-suppressed feeding (Mineur et al, 2007;Borah et al, 2018). A more recent study also showed that the antidepressant effect of CEF was comparable to that of fluoxetine in the tail suspension test in a dose-dependent manner (Borah et al, 2018).…”

Section: Antidepressant Effects Of Cefmentioning

confidence: 70%

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

2019

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To date, there is no cure or disease-modifying agents available for most well-known neurological disorders. Current therapy is typically focused on relieving symptoms and supportive care in improving the quality of life of affected patients. Furthermore, the traditional de novo drug discovery technique is more challenging, particularly for neurological disorders. Therefore, the repurposing of existing drugs for these conditions is believed to be an efficient and dynamic approach that can substantially reduce the investments spent on drug development. Currently, there is emerging evidence that suggests the potential effect of a beta-lactam antibiotic, ceftriaxone (CEF), to alleviate the symptoms of different experimentally-induced neurological disorders: Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, epileptic-seizure, brain ischemia, traumatic brain injuries, and neuropathic pain. CEF also affects the markers of oxidative status and neuroinflammation, glutamatergic systems as well as various aggregated toxic proteins involved in the pathogenesis of different neurological disorders. Moreover, it was found that CEF administration to drug dependent animal models improved the withdrawal symptoms upon drug discontinuation. Thus, this review aimed to describe the effects of CEF against multiple models of neurological illnesses, drug dependency, and withdrawal. It also emphasizes the possible mechanisms of neuroprotective actions of CEF with respective neurological maladies.

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Section: Antidepressant Effects Of Cefmentioning

confidence: 70%

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

2019

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“…Mouse was viewed as stable when it inactively hung with bar without any endeavors to get away. 23 -26…”

Section: Methodsmentioning

confidence: 99%

Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

et al. 2019

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The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders.

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“…The rats were then allowed to dry in a pre-washed enclosure (~32°C) before being returned to their cages. The decrease in the duration of immobility is a measure of antidepressant activity [22].…”

Section: Fstmentioning

confidence: 99%

Evaluation of Sirtuin 3 Biomarker Before and After Exercise Regimen in Chronic Unpredictable Mild Stress-Induced Depressed Rats

Sowndarya¹,

Doss²

2019

Asian J Pharm Clin Res

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Objective: Depression is one of the most common psychiatric illnesses that cause disability and public health problems. Physical exercise has been shown to reduce the stress impairment and ameliorate depressive symptoms. The objectives of the present study were to confirm, whether swimming exercise alleviates the depression-like behavior induced by chronic unpredictable mild stress (CUMS) through the alteration in the expression of sirtuin 3 (sirt 3) in brain.Methods: This study was undertaken to evaluate the possible antidepressant activity of exercise. Female Wistar rats weighing about 120–150 g were divided into four groups of six animals in each: Control, CUMS-induced, venlafaxine-treated, and exercise-treated groups. The rat model of depression was established using CUMS protocol. Behavioral assessment was performed by sucrose consumption test and forced swim test. Semi-quantitative reverse transcription-polymerase chain reaction and Western blot analysis were performed to study the gene expression and the protein activity of SIRT3.Results: Our results showed that the gene expression and protein activity of sirt3 were found to be significantly increased in the exercise-treated group when compared to the depressed group.Conclusion: The interesting fact from this study is that swimming exercise increases sirt3 expression and possesses a beneficial effect in curing depression.

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Anti-Depressant Effect of Ceftriaxone in Forced Swimming Test and in Tail Suspension Test in Mice

Cited by 7 publications

References 19 publications

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

Evaluation of Sirtuin 3 Biomarker Before and After Exercise Regimen in Chronic Unpredictable Mild Stress-Induced Depressed Rats

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