Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models

Abstract

The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated by using open field, elevated plus maze, force swimming, and tail suspension test. Results of open field test showed an increase in number of line crossing as well as number of rearing in dosage-dependent design. Although results of elevated plus maze test evidently showed antianxiety effect of O bracteatum by increasing the time spent in open arms along with decreasing the time spent in closed arms in dosage-dependent way. For the evaluation of antidepressant effect, O bracteatum diminished the immobility time and expanded mobility time in forced swim model in dosage-dependent way. Likewise, O bracteatum expanded time span of mobility along with diminished immobility time in tail suspension method in dosage-dependent way. Outcome demonstrated that plant at the dose of 200 mg/kg body weight showed significant potential which was similar to that standard diazepam and fluoxetine. Hence, O bracteatum may be used as potent natural psychotherapeutic agent against the mental disorders.

Antioxidant Phytoconstituents From Onosma bracteata Wall. (Boraginaceae) Ameliorate the CCl4 Induced Hepatic Damage: In Vivo Study in Male Wistar Rats

“…accompanied with CCl 4 (i.p) treatment. The experimental concentrations of Obeth have been decided based on the literature report on O. bracteata in in vivo studies ( Asif et al, 2019 ).…”

“…Group, I served as control; Group II intoxicated with 1 mL kg -1 CCl 4 (mixed in same volume of olive oil via intraperitoneal (i.p.) doses, 3 days in a week) which induced liver mutilation and is mostly used for analyzing the hepatoprotective potential of various drugs (Ritesh et al, 2015;Zamzami et al, 2019) (Asif et al, 2019).…”

Chemical Profiling and Dose-Dependent Assessment of Fear Reducing and Memory-Enhancing Effects of Solanum virginianum in Rats

“…20 Irrespective of the availability of different drugs for depression and anxiety, it is still a challenge to minimize the symptoms of these ailments to the fullest due to encountered adverse effects, less efficacy and poor tolerance. 21 Plant-based preparations have been tremendously adopted as an alternative option for the management of a range of health issues including neurological ones. 22 The researcher's efforts on medicinal plants to discover new therapeutic molecules are continuously yielding evidence of their pharmacological usefulness in different animal models.…”

“… 20 Irrespective of the availability of different drugs for depression and anxiety, it is still a challenge to minimize the symptoms of these ailments to the fullest due to encountered adverse effects, less efficacy and poor tolerance. 21 …”

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

“…e text was conducted according to previously established protocols [29]. e mice swam in a glass beaker filled with water at 24°C for 15 min before testing [30]. During the test, mice were placed separately into the glass beaker for 6 min.…”