Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential

Mollica, Adriano; Zengin, Gökhan; Locatelli, Marcello; Stefanucci, Azzurra; Mocan, Andrei; Macedonio, Giorgia; Carradori, Simone; Onaolapo, Olakunle James; Onaolapo, Adejoke Yetunde; Adegoke, Juliet; Olaniyan, M. O.; Novellino, Ettore

doi:10.1016/j.jff.2017.05.001

Cited by 127 publications

(63 citation statements)

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“…However, several of these drugs – for instance, α ‐glucosidase and α ‐amylase inhibitors used to treat diabetes mellitus, and cholinesterase and tyrosinase inhibitors used for managing Alzheimer's disease and hyperpigmentation respectively – have been found to pose side effects such as gastrointestinal disturbance and liver damage. There is, therefore, an urgent need to search for alternative inhibitors from natural sources with minimal or no side effects . Considering the aspects mentioned, the enzyme inhibitory properties of three Crataegus species toward cholinesterases, α ‐amylase, α ‐glucosidase, and tyrosinase were investigated, and the results are illustrated in Table .…”

Section: Resultsmentioning

confidence: 99%

“…There is, therefore, an urgent need to search for alternative inhibitors from natural sources with minimal or no side effects. 40,[42][43][44] Considering the aspects mentioned, the enzyme inhibitory properties of three Crataegus species toward cholinesterases, ⊍-amylase, ⊍-glucosidase, and tyrosinase were investigated, and the results are illustrated in Table 4.…”

Section: Wileyonlinelibrarycom/jsfamentioning

confidence: 99%

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Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

et al. 2020

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BACKGROUND In this investigation, the chemical and biological profiles of three Turkish Crataegus species (Crataegus orientalis, Crataegus szovitsii and Crataegus tanacetifolia) were studied in order to provide the first comprehensive characterization and their health‐promoting potential. In this respect, polyphenolic profiles were evaluated using ultrahigh‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry. The in vitro antioxidant activities of the Crataegus samples were evaluated by using free‐radical scavenging, phosphomolybdenum, ferrous‐ion chelating, and reducing power assays. The inhibitory activities against α‐glucosidase, amylase, cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)), and tyrosinase were also established. RESULTS The untargeted metabolomic approach highlighted the effect of both extraction types and species on the phenolic profiles of different Crateagus tissues (i.e. leaves and twigs). The methanolic extracts showed the maximum radical scavenging and reducing activity in all test systems, whereas for ferrous‐ion chelating assays the decocted and infused extracts showed the highest activity. Only the methanolic extracts were effective against AChE and BChE. The extract tested showed remarkable inhibitory effects against tyrosinase and α‐glucosidase, whereas all the extracts exhibited modest inhibition against α‐amylase. Overall, the twig extracts of the three species studied showed superior antioxidant and enzyme inhibitory activities. CONCLUSION On the basis of these results, the three Crataegus species can be classified as potent bioresources for high‐value phytochemicals, which warrant further investigations for developing novel nutraceuticals. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Section: Wileyonlinelibrarycom/jsfamentioning

confidence: 99%

Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

et al. 2020

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“…O 2 ·− , superoxide radical; OH · , hydroxyl radical) and non‐radical forms (H 2 O 2 , hydrogen peroxide; 1 O 2 , singlet oxygen) are continuously generated as a consequence of metabolic activities in living organisms. The imbalance of ROS levels and cellular antioxidant endogenous mechanisms of the body leads to oxidative stress, which has a direct and/or indirect role in the pathology of many chronic diseases including cardiovascular disease, diabetes and dementia . In line with the increasing strong consumer demand for safe medication from natural sources to combat oxidative stress, there has been a renewed interest and engagement of researchers in evaluating medicinal plants in the quest for novel sources of antioxidants over the last decade.…”

Section: Resultsmentioning

confidence: 99%

Chemical fingerprint and bioactivity evaluation of Globularia orientalis L. and Globularia trichosantha Fisch. & C. A. Mey. using non‐targeted HPLC‐ESI‐QTOF‐MS approach

Rodríguez‐Pérez

Zengin

Segura‐Carretero

et al. 2018

Phytochemical Analysis

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Introduction In the quest for new sources of biologically‐active compounds, the chemical, and biological profiles of two Globularia species (G. trichosantha Fisch. & C. A. Mey and G. orientalis L.) were investigated. Methodology Chemical profiles were evaluated by high‐performance liquid chromatography coupled to electrospray ionisation and quadrupole time‐of‐flight mass spectrometry (HPLC‐ESI‐QTOF‐MS), as well as by their total phenolic, flavonoids, and phenolic acids contents. The antioxidant abilities of the investigated extracts were done using different assays including free radical scavenging [1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid (ABTS)], reducing power (cupric reducing antioxidant capacity and ferric reducing antioxidant power), phosphomolybdenum, and metal chelating. Inhibitory potential against key enzymes involved in neurodegenerative diseases (cholinesterases; AChE, and BChE), diabetes (α‐glucosidase and α‐amylase), hyperpigmentation (tyrosinase) and obesity (pancreatic lipase) were evaluated. Results Globularia trichosantha and G. orientalis extracts showed remarkable antioxidant properties, with the water extracts being a better source of antioxidant compounds. Both species showed remarkable inhibitory effects against the target enzymes. However, for both species, only the acetyl acetate and methanolic extracts were potent against cholinesterases and lipase. Conclusion HPLC‐ESI‐QTOF‐MS analysis revealed the presence of 107 compounds from G. trichosantha and G. orientalis, among which, 43 compounds have been preliminarily characterised for the first time from the Globulariaceae family. To date, this study can be considered as the most comprehensive research focused on the characterisation of G. trichosantha and G. orientalis. Results amassed from this study tend to show that these plants represent a rich source of biologically active compounds which can be further explored and validated for their therapeutic potential.

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“…[ ][ ] Previous studies have documented that STZ induced diabetes leads to significant body weight loss. The loss of weight experience in diabetic situation had been attributed to the breakdown and use of available proteins and fats as energy source due to the inability of the body to utilize glucose for energy . Treatment with LFE caused a remarkable increase in the body weight of the treated rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

Olatunji

Chen

Zhou

2017

Chemistry & Biodiversity

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Lycium chinenseMill., popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols-rich ethyl acetate fraction from the leaves of Lycium chinenseMill. on streptozotocin-nicotinamide induced diabetic rats. The ethyl acetate fraction (LFE) was selected and orally gavaged at 100, 200, and 400 mg/kg dose to streptozotocin (STZ)-nicotinamide induced diabetic rats. The rats' body weight, fasting blood glucose (FBG), lipid profile and oxidative stress markers were evaluated after the treatment period. Treatment with LFE resulted in a significant decrease in the FBG level, altered lipid profiles, and reduced the activities of the enzymes alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT) in the treated diabetic rats. Furthermore, LFE significantly elevated the antioxidant status (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities) and reducing malondialdehyde (MDA) levels in the treated rats. The present study has revealed that L. chinenseMill. possess anti-hyperglycemic and anti-hyperlipidemic properties which is mediated through modulation of oxidative stress and polyphenolics might be responsible for the action.

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Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential

Cited by 127 publications

References 36 publications

Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

Untargeted metabolomic profiling of three Crataegus species (hawthorn) and their in vitro biological activities

Chemical fingerprint and bioactivity evaluation of Globularia orientalis L. and Globularia trichosantha Fisch. & C. A. Mey. using non‐targeted HPLC‐ESI‐QTOF‐MS approach

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

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