Anti-Diabetic and Reno-Protective Effect of the Ethanolic Extract of Solanum Indicum in Alloxan-Induced Diabetic Rats

Borgohain, Raktim; Pathak, Pradumna; Mohan, Roopshekhar

doi:10.14260/jemds/2016/1650

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Essentially, bioactive compounds of some of the investigated plants in this study have produced antidiabetic effects by acting on specific targets (For example, agonists of PPARγ such as Citrus sinensis (L.) Osbeck) [124], while other researchers only reported antidiabetic activities without definite pharmaceutical targets [144,145]. For successful drug development, it is pivotal to identify and select targets of therapeutic compounds.…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 98%

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

et al. 2023

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Diabetes mellitus (DM) is a global health problem owing to its high prevalence and increased morbidity and mortality. The prevalence of DM and impaired glucose tolerance in Uganda is approximately 4.1% and 6.6%, respectively. Medicinal plants are commonly used for the management of DM, especially in developing countries, such as Uganda. According to several ethnobotanical surveys conducted in Uganda, various medicinal plants are used in DM management. Meanwhile, ethnopharmacological studies have confirmed the anti-diabetic efficacy of various plants and plant-derived formulations from Uganda. However, these information remain highly fragmented without a single repository for plants used in the management and treatment of DM in Uganda, hindering further investigations. Therefore, this study aimed to comprehensively explore plants used for DM treatment in Uganda and retrieve relevant ethnopharmacological and ethnomedicinal information that can be used for DM therapy development. English peer-reviewed articles and books were searched in scientific databases, especially PubMed, Scopus, Google Scholar, Science Direct, SciFinder, and Medline, to retrieve information on medicinal plants used for DM treatment and management in Uganda. The databases were searched to obtain published literature on the anti-diabetic activities and safety of plants among the identified plants. The family name, plant parts used, anti-diabetic activities, dosage, and mechanisms of action of plant extracts were captured. In total, 46 species belonging to 26 families are used to treat DM in Uganda. Most species belonged to the Fabaceae (20%), Asteraceae (13%), and Solanaceae (7%) families. Anti-diabetic activities of 27 (59%) species have been scientifically investigated, whereas the rest have not been evaluated. This review indicated that various medicinal plants are used in the traditional treatment and management of DM across different regions in Uganda. Scientific investigations have revealed the anti-diabetic potential and safety of several of these plants. However, there is a need to validate the anti-diabetic potential of other unstudied plants. Additionally, isolating and characterizing active principles and elucidating the anti-diabetic mechanism of these plants and performing preclinical and clinical studies in the future could aid in the formulation of an effective and safe treatment for DM.

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Section: In Vitro and In Vivo Studiesmentioning

confidence: 98%

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

et al. 2023

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“…Hence, α-amylase and α-glucosidase inhibitors slow the digestion of starch in the small intestine, which decreases the amount of glucose entering the bloodstream leading to an improved insulin response [ 138 ]. Previous studies reported the hypoglycemic effects of SILF [ 139 ] and S. melongena [ 140 ], and these may have been mediated through inhibiting the α-amylase and α-glucosidase, due to the presence of phenolic compounds. The TPC in SALF (mg GAE/g DW) is substantially higher than in SILF [ 120 ], suggesting inhibiting properties of SALF regarding α-amylase and α-glucosidase activity, which may be mediated by tannins as similar effects have been reported for tannin-containing Terminalia chebula Retz [ 141 ].…”

Section: Solanum Anguivi Lam Fruit’s Antidiabementioning

confidence: 99%

Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus

et al. 2021

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Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder of glucose homeostasis associated with a status of insulin resistance, impaired insulin signaling, β-cell dysfunction, impaired glucose and lipid metabolism, sub-clinical inflammation, and increased oxidative stress. Consuming fruits and vegetables rich in phytochemicals with potential antidiabetic effects may prevent T2DM and/or support a conservative T2DM treatment while being safer and more affordable for people from low-income countries. Solanum anguivi Lam. fruits (SALF) have been suggested to exhibit antidiabetic properties, potentially due to the presence of various phytochemicals, including saponins, phenolics, alkaloids, ascorbic acid, and flavonoids. For the saponin fraction, antidiabetic effects have already been reported. However, it remains unclear whether this is also true for the other phytochemicals present in SALF. This review article covers information on glucose homeostasis, T2DM pathogenesis, and also the potential antidiabetic effects of phytochemicals present in SALF, including their potential mechanisms of action.

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Hyperglycaemic Metabolic Complications of Ischemic Brain: Current Therapeutics, Anti-Diabetics and Stem Cell Therapy

Chavda

Patel

2023

CNSNDDT

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Stroke is the leading cause of morbidity and mortality in diabetic patients. Diabetes alters endothelial function and disrupts brain pathways, resulting in a variety of systemic metabolic complications. Diabetics not only have impaired neurotransmission, but they also have progressive neurodegeneration, which leads to long-term neurological complications. Diabetes risk factors and physiology alter the frequency and severity of cardiovascular and cerebrovascular events, necessitating more hospitalizations. Stroke and diabetes have a mutually reinforcing relationship that worsens their outcomes. Diabetes has far-reaching systemic consequences for human physiology as a metabolic syndrome. As a result, diabetic stroke patients require dual-therapeutics with dual protection. Scientific researchers have made tremendous progress in diabetes-related stroke and its therapeutics over the last few decades. We have summarised diabetic brain and associated risk factors, co-morbidities, biomarkers and hyperglycemia associated neurovascular insult and cognitive demur. In addition to providing an overview of the effects of hyperglycaemia on brain physiology, this article aims to summarise the evidence from current glucose-lowering treatment, recent advances in stroke therapeutics as well as exploring stem cell therapy in the management of diabetes associated stroke.

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Anti-Diabetic and Reno-Protective Effect of the Ethanolic Extract of Solanum Indicum in Alloxan-Induced Diabetic Rats

Cited by 4 publications

References 4 publications

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda

Solanum anguivi Lam. Fruits: Their Potential Effects on Type 2 Diabetes Mellitus

Hyperglycaemic Metabolic Complications of Ischemic Brain: Current Therapeutics, Anti-Diabetics and Stem Cell Therapy

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