Anti Fungal and Acute Toxicity Activities of Novel 2,4,6-Trisubstituted Pyrimidines.

Abstract

Frequency of microbial infection is progressively increasing worldwide. New emerging strain of bacterium and resistance to currently available drugs make this field more conscientious and alarming. Effective antimicrobials are available for treatment since long back. As toxicity became a major criteria for usage of drugs now a days, many potent antibiotic are of restricted use in clinical practice. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A new class of heterocyclic 2, 4, 6 tri substituted pyrimidines were prepared from chalcones. The Structures of these compounds were established on the basis of IR and 1 H NMR data. Synthesized compounds were evaluated for antimicrobial and cytotoxicity activities. Among all, 2",4"-di fluoro phenyl substituted pyrimidine derivative have shown significant antifungal activity against pathogenic fungi like Aspergillus niger, Candida tropicalis and most compounds have shown no significant cytotoxicity in HT-29, MCF-7 and DU-145 cell lines. This impressive cytotoxicity and anti microbial action encourages us to synthesize novel pyrimidines for desired action.