Anti‑glycolipid disorder effect of epigallocatechin‑3‑gallate on high‑fat diet and STZ‑induced T2DM in mice

Abstract

epigallocatechin-3-gallate (eGcG) is beneficial for inhibiting dyslipidemia and reducing hyperlipidemic risk. The purpose of the present study was to investigate the glycolipid regulatory effects and potential mechanisms of eGcG in a high-fat diet and streptozotocin-induced type 2 diabetes mellitus (T2dM) mouse model. The results demonstrated that eGcG can decrease blood glucose levels and increase insulin resistance in T2dM mice. in addition, eGcG can regulate serum lipid levels, including those of total cholesterol, triglyceride and low-density lipoprotein receptor (ldl-r), and reduce lipid deposition in vascular endothelial cells in a dose-dependent manner. in addition, the gene and protein expression of related scavenger receptors, including cluster of differentiation 36, sterol regulatory element binding protein 2 (SreBP), SreBP cleavage-activating protein and ldl-r, were downregulated in a dose-dependent manner. The present study noted that eGcG possesses potential as a natural product for preventing and treating metabolic hyperlipidemia syndrome, probably by reducing the blood lipid levels, alleviating vascular endothelial cell damage, maintaining normal lipid metabolism in blood vessels and ameliorating glycolipid disorders.

Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats

“…EGCG down-regulated glucose levels and up-regulated C-peptide levels in T2DM mice. 35 In summary, the current study demonstrated that EGCG modulates blood glucose in T2DM rats. Lowering blood sugar, helping maintain body mass, and reducing oxidative stress is of great significance for lipid regulation, insulin resistance, and cardiovascular protection.…”

The Effects of GABA-Rich Adzuki Beans on Glycolipid Metabolism, as Well as Intestinal Flora, in Type 2 Diabetic Mice

“…Generally, impaired glycolipid metabolism is a significant complication of T2DM ( 21 ), closely associated with high-calorie diets and obesity ( 22 ). Glycolipid metabolism can promote metabolic abnormalities and insulin resistance, leading to increased glucose production and defects in insulin secretion in the liver ( 23 ).…”

Bioactivity of Dietary Polyphenols: The Role in LDL-C Lowering

“…Substantial evidence suggests that EGCG elicit a wide range of properties, including antioxidant and antilipid deposition and anti-inflammation [141][142][143]. Extensive studies have shown that the consumption of EGCG exhibited an LDL-C reducing effect [144][145][146][147]. A systematic review found that EGCG could significantly decrease the plasma LDL-C level at doses between 107 and 856 mg/d [148][149][150].…”