Anti-HCV seroprevalence and risk factors of hepatitis C virus infection in Moroccan population groups

Benjelloun, Soumaya; Bahbouhi, Bouchaib; Sekkat, Souad; Bennani, Abdelouaheb; Hda, Nezha; Benslimane, A.

doi:10.1016/0923-2516(96)89656-7

Cited by 28 publications

(23 citation statements)

References 34 publications

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“…(30) Another study was excluded because the full text was not available and there was not enough information in the abstract. Furthermore, we did not receive any response from the authors of the article after 1 month of our e-mail request for the full text (31). In addition, we excluded an article because of its selection bias and overestimation as it was reported previously (32), although there was enough data and an acceptable sample size (33).…”

Section: Search Results and Study Selectionmentioning

confidence: 99%

Lack of Knowledge About Hepatitis C Infection Rates Among Patients With Inherited Coagulation Disorders in Countries Under the Eastern Mediterranean Region Office of WHO (EMRO): A Meta-Analysis

Alavian

Aalaei‐Andabili²

2012

Hepat Mon

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Context: Hepatitis C virus (HCV) infection is a public health problem. HCV alone is responsible for 90% cases of acute hepatitis among multiply transfused patients who are at risk of cirrhosis and hepatocellular carcinoma (HCC). Objectives: To provide a clear picture of available data, we performed a systematic review of the epidemiological characteristics of HCV infection among patients with inherited coagulation disorders in the countries under the Eastern Mediterranean Region Office (EMRO). Evidence Acquisition: Meta-analysis was carried out on the basis of results of electronic and manual search. This analysis included studies in English, French, and Persian that met with the following criteria: (1) appropriate study design: cross-sectional, case-control, and cohort; (2) studies reporting HCV prevalence according to enzyme immune assay; (3) studies in which the sample population was enrolled from EMRO countries. According to the results of the heterogeneity tests, we used fixed-effect/random-effect model for our meta-analysis, with the "Metan" command. Results:We included 30 studies, most of which were from Iran. The mean age of the subjects ranged from 13 to 27.1 years. The majority of the patients were male (range, 81% to 100%). The pooled estimate of HCV infection among patients with inherited coagulation disorders was 48.07% (95% confidence interval [CI], range: 27.39-55.68) in Iran, 36.03% (95% CI, range: 4.466-67.598) in Pakistan, and 48.27% (95% CI,) in all the EMRO countries taken together. Conclusions: In Iran and other EMRO countries, the HCV infection rate among patients with inherited coagulation disorders is high. Our study shows that there is a lack of knowledge about infections in such patients in most of the EMRO countries. It is the responsibility of health-policy makers to address this knowledge gap and provide safe and adequate treatment for patients in high-risk groups.

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Section: Search Results and Study Selectionmentioning

confidence: 99%

Lack of Knowledge About Hepatitis C Infection Rates Among Patients With Inherited Coagulation Disorders in Countries Under the Eastern Mediterranean Region Office of WHO (EMRO): A Meta-Analysis

Alavian

Aalaei‐Andabili²

2012

Hepat Mon

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“…Different studies were carried out on HCV in Morocco both in the general population and on higher risk groups. Early studies estimated that the prevalence of HCV was 1.93% in the general population and 1.08% in blood donors [31]. A recent nationwide cross-sectional survey carried out in 100 major Moroccan regions over a period of six years showed that the overall prevalence of HCV infection in the general population was 1.58%, and it was lower among blood donors [10].…”

Section: Epidemiology Of Hcv In the Maghreb Regionmentioning

confidence: 99%

Hepatitis C Virus in North Africa: An Emerging Threat

Daw

El-Bouzedi

Ahmed

et al. 2016

The Scientific World Journal

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Hepatitis C virus is a major public health threat associated with serious clinical consequences worldwide. North Africa is a unique region composed of seven countries that vary considerably in the predisposing factors to microbial diseases both historically and at the present time. The dynamics of HCV in the region are not well documented. The data are both limited and controversial in most of the countries in the region. In North Africa, the epidemiology of HCV is disparate and understanding it has been hampered by regional “epidemiological homogeneity” concepts. As the dynamics of HCV vary from country to country, context-specific research is needed. In this review, we assess studies performed in each country in the general populations as well as among blood donors and groups exposed to the HCV infection. The reported prevalence of HCV ranges from 0.6% to 8.4% in the Maghreb countries and is predominated by genotype 1. In the Nile valley region, it ranges from 2.2% to 18.9% and is dominated by genotype 4. In North African countries, HCV seems to be a serious problem that is driven by different vectors even in different geographical locations within the same country. Efforts should be combined at both the national and regional levels to implement efficient preventive and treatment strategies.

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“…In Central and Southern African countries, HCV prevalence ranges from less than 1% (e.g., Zambia and Zimbabwe) [World Health Organization, 1997] to 6% (e.g., Cameroon and Zaire) [Tibbs et al, 1991;Ndumbe and Skalsky, 1993]. In North Africa, HCV prevalences vary greatly between countries: in Egypt HCV infection is highly endemic (14%) [Rall and Dienstag, 1995], while significantly lower prevalences have been reported in Morocco, Algeria, and Tunisia: 1.1%, 0.18%, and 0.4-0.7%, respectively [Ayed et al, 1995;Benjelloun et al, 1996;Triki et al, 1997;Gorgi et al, 1998]. The distribution of HCV genotypes also varies between countries: type 4 is the most prevalent genotype in Egypt (91%) [Stuart et al, 2000], while previous studies reported large predominance of subtype 1b in Tunisia [Djebbi et al, 2003] and Morocco [Benani et al, 1997].…”

Section: Introductionmentioning

confidence: 99%

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

Mejri

Salah

Triki

et al. 2005

Journal of Medical Virology

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This report is a population-based study describing the pattern of hepatitis C virus (HCV) infection in two distinct regions in Tunisia. The study included a total of 11,507 individuals sampled in 1996 from both genders, all age groups, urban and rural settings belonging to 2,973 families. HCV infection was assessed by commercial enzyme immunoassay (EIA) and immunoblot assays and detection of HCV RNA by PCR. HCV genotypes and subtypes were determined by sequencing in the 5'-untranslated region (UTR) viral genomic region and the INNO-LiPA HCVII genotyping kit. Genetic relatedness between HCV strains was assessed by sequencing of a portion of the NS5B region. HCV prevalence was significantly higher in the North-Western region than in the Southern one: 1.7% versus 0.2% (P < 10(-3), chi(2) = 8,506). There was no difference in positivity according to gender or living in rural or urban settings; the only significant risk factor was advanced age. HCV prevalence among household contacts of HCV positives was not significantly higher than the prevalence in the whole study population. These results indicate a heterogeneity in the geographical distribution of HCV in Tunisia. An increased HCV transmission occurs in the North-Western region with large predominance of genotype 1b (88%) and low contribution of intrafamilial transmission.

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Anti-HCV seroprevalence and risk factors of hepatitis C virus infection in Moroccan population groups

Cited by 28 publications

References 34 publications

Lack of Knowledge About Hepatitis C Infection Rates Among Patients With Inherited Coagulation Disorders in Countries Under the Eastern Mediterranean Region Office of WHO (EMRO): A Meta-Analysis

Lack of Knowledge About Hepatitis C Infection Rates Among Patients With Inherited Coagulation Disorders in Countries Under the Eastern Mediterranean Region Office of WHO (EMRO): A Meta-Analysis

Hepatitis C Virus in North Africa: An Emerging Threat

Contrasting patterns of hepatitis C virus infection in two regions from Tunisia

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