Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus

Alahdal, Abdulrahman M.; Asfour, Hani Z.; Ahmed, Safwat A.; Noor, Adeeb; Al‐Abd, Ahmed M.; Elfaky, Mahmoud A.; Elhady, Sameh S.

doi:10.3390/molecules23040978

Cited by 38 publications

(40 citation statements)

References 60 publications

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“…In addition, compounds 61-68 showed cytotoxic activities against three human cancer cell lines (HePG-2, MCF-7, and HCT-116), with a range of IC50 values from 0.29 to 2.1 μg/mL [82]. Figure 13) [84]. Sesterstatin 7 (72) was also isolated from the sponge Hyrtios erectus, collected from Safaga in Egypt [85].…”

Section: Spongesmentioning

confidence: 99%

“…Dysidamide (78) led to entire and rapid death of mesencephalic and cortical murine neurones at a dose of 0.8 µg/mL [91]. The two cytotoxic metabolites asmarine A (79) and asmarine B (80) were identified and isolated from the marine sponge Raspailia sp., collected from Dahlak archipelago, Eritrea (Figure 14 Figure 13) [84]. Sesterstatin 7 (72) was also isolated from the sponge Hyrtios erectus, collected from Safaga in Egypt [85].…”

Section: Spongesmentioning

confidence: 99%

“…Hyrtiomanzamine (83) showed immunosuppressive activity in the B lymphocytes reaction assay with EC 50 value of 2 µg/mL, with no cytotoxicity against KB cells [95]. The polyacetylene derivative petrosolic acid (84) was isolated from the sponge Petrosia sp. (Figure 15).…”

Section: Spongesmentioning

confidence: 99%

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Natural Products Repertoire of the Red Sea

et al. 2020

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Marine natural products have achieved great success as an important source of new lead compounds for drug discovery. The Red Sea provides enormous diversity on the biological scale in all domains of life including micro- and macro-organisms. In this review, which covers the literature to the end of 2019, we summarize the diversity of bioactive secondary metabolites derived from Red Sea micro- and macro-organisms, and discuss their biological potential whenever applicable. Moreover, the diversity of the Red Sea organisms is highlighted as well as their genomic potential. This review is a comprehensive study that compares the natural products recovered from the Red Sea in terms of ecological role and pharmacological activities.

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Section: Spongesmentioning

confidence: 99%

Section: Spongesmentioning

confidence: 99%

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Natural Products Repertoire of the Red Sea

et al. 2020

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“…Doxorubicin was used a positive control. The linear relationship between the viability percentage of each tumor cell line and the extracts' concentrations were analyzed to obtain the IC 50 (dose of the drug which reduces survival to 50%) using SigmaPlot 12.0 software [50].…”

Section: Cytotoxicity Studiesmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

et al. 2020

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Kleinia pendula (Forssk.) DC. is a prostrate or pendent dark green succulent herb found in the southwestern mountain regions of Saudi Arabia. The literature survey of the plant reveals a lack of phytochemical and pharmacological studies, although traditional uses have been noted. The objective of the present work was to assess the in vivo analgesic and anti-inflammatory activities, as well as, the in vitro cytotoxic potential of the fractions of Kleinia pendula, and correlate these activities to the plant metabolites. The methanolic extract of Kleinia pendula was subjected to fractionation with n-hexane, ethyl acetate, chloroform, n-butanol, and water. The fractions were screened for their analgesic and anti-inflammatory activities, as well as cytotoxic activity against breast, liver, and colon cancer cell lines. The n-hexane and chloroform fractions of Kleinia pendula showed significant cytotoxic activity against all three cancer cell lines tested. The ethyl acetate and chloroform fractions showed significant analgesic and anti-inflammatory activities. The metabolites in these three active fractions were determined using UPLC-PDA-ESI-MS. Thus, the analgesic and anti-inflammatory activities of the plant were attributed to its phenolic acids (caffeoylquinic acid derivatives, protocatechuic, and chlorogenic acids). While fatty acids and triterpenoids such as (tormentic acid) in the hexane fraction are responsible for the cytotoxic activity; thus, these fractions of Kleinia pendula may be a novel source for the development of new plant-based analgesic, anti-inflammatory, and anticancer drugs.

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“…The cytotoxic activity (Table 2) of the compounds on lung cancer A-549, cervical cancer HeLa, prostate cancer DU-145, hepatocellular carcinoma HepG2, and breast-adenocarcinoma MCF-7 cells was determined using an SRB assay [44,45], as mentioned in our study [46].…”

Section: Cytotoxicity Of Compounds 1-4mentioning

confidence: 99%

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

et al. 2020

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Chemical investigation of the ethyl acetate extract of Penicillium chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, led to the isolation of a cerebroside molecular species LAMA (1) along with three other known compounds, ergosterol (2), epidioxyergosterol (3), and kojic acid (4). The structures of the isolated compounds were elucidated by interpretation of spectral data, including detailed 1D and 2D NMR (One and two dimensional Nuclear Magnetic Resonance) and mass spectrometry. The cytotoxic activities of isolated compounds 1–4 against five human carcinoma cells were evaluated using sulforhodamine B (SRB) assay. Compounds 2 and 3 displayed promising cytotoxic profiles against lung cancer (A-549), prostate (DU-145), breast adenocarcinoma (MCF-7), and hepatocellular (HepG2) cell lines, with IC50 values of 21.26, 19.3; 1.50, 6.10; 16.95, 13.6; and 2.89, 3.07 µM, respectively, while they were inactive against HeLa cells. Compounds 1 and 4 showed weak cytotoxic profiles against all cell lines under investigation.

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Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus

Cited by 38 publications

References 60 publications

Natural Products Repertoire of the Red Sea

Natural Products Repertoire of the Red Sea

Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of Kleinia pendula

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

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