Anti-Helicobacter pylori Diarylheptanoid Identified in the Rhizome of Alpinia officinarum

Lee, Haeng-Byung; Lee, Hyun-Kyung; Kim, Jun-Ran; Ahn, Young‐Joon

doi:10.3839/jksabc.2009.065

Cited by 14 publications

(8 citation statements)

References 18 publications

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“…Diarylheptanoid from the rhizome of Alpinia officinarum inhibited three standard H. pylori strains in vitro with MICs of 48, 24, and 24 μg/mL, respectively, which were comparable to that of metronidazole (32, 16, and 16 μg/mL; Lee et al, 2009). In another study, cowaxanthone and fukugiside isolated from the roots of Garcinia fusca showed stronger antibacterial activities against H. pylori DMST 20165 in vitro than those of the control (metronidazole) with MICs of 4.6 and 10.8 μmol/L, respectively (Nontakham et al, 2014).…”

Section: Anti-h Pylori Activitymentioning

confidence: 81%

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Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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Helicobacter pylori is the main pathogen that induces chronic gastritis, peptic ulcers, atrophic gastritis, and other gastric disorders, and it is classified as a group I carcinogen. To eradicate H. pylori infection, triple therapy consisting of two antibiotics and a proton pump inhibitor is the most widely recommended first-line therapeutic strategy. Antimicrobial resistance to antibiotics contained in triple therapy could lead to therapeutic regimen failures. Recent studies showed that many natural products, including fruits, vegetables, spices, and medicinal plants, possess inhibitory effects on H. pylori, indicating their potential to be alternatives to prevent and manage H. pylori infection. This review summarizes the effects of natural products on H. pylori infection and highlights the mechanisms of action.

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Section: Anti-h Pylori Activitymentioning

confidence: 81%

“…Spices, used as seasonings and therapeutic agents for a long time, were found to have antimicrobial activities and anticancer properties . Some studies also revealed the anti-H. pylori activities of spices (Lee, Lee, Kim, & Ahn, 2009).…”

Section: Inhibitory Effects Of Spices On H Pylori Infectionmentioning

confidence: 99%

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Liu

Meng

et al. 2018

Comp Rev Food Sci Food Safe

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“…a) Anti-bacterial activity. Diarylheptanoids isolated from A. officinarum especially 5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenyl-3-heptanone, showed anti-Helicobacter pylori activity (Lee et al, 2009). Curcumin can inhibit the growth of several bacteria species like Streptococcus, Staphylococcus and Lactobacillus (Bhavani-Shankar and Sreenivasamurthy, 1979).…”

Section: Acer Nikoensementioning

confidence: 99%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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Phenolic compounds are naturally occurring compounds present ubiquitously in plants. They have potential health benefits and substantiate evidence for their nutraceutical applications. Diarylheptanoids are part of the broad class of plant phenolics with structurally divergent compounds. They have been used in traditional medicines and homemade remedies to treat various ailments, as organoleptic additives in foods, and also for aesthetic purposes. With their potential therapeutic and organoleptic characteristics, diarylhepatanoids can be rightly termed as nutraceuticals. This review summarizes the wide range of pharmacological activities of diarylhepatanoids and nutraceutical formulations, with relevance to human health.

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“…Corydalis Rhizoma , Coptidis Rhizoma and Alpinia officinarum , important components of HZJW, were proved to be effective in the prevention of H . pylori infection [12,13]. Berberine and its protoberberine alkaloids palmatine, coptisine and aporphinoid alkaloid of magnoflorine have been confirmed to be the major pharmacologically active constituents of Coptidis Rhizoma against H .…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

Xie

Chen

Qing-he

et al. 2013

BMC Complement Altern Med

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BackgroundA traditional Chinese Medicine (TCM) formula, HZJW, has been applied in clinics in China for gastrointestinal disorders. However, the therapeutic mechanism underlying its efficacy and safety remained to be defined. The present investigation was undertaken to evaluate the formula HZJW for its gastroprotective potential, possible effect on Helicobacter pylori along with safety to justify its anti-ulcer action and safe clinical application.MethodsThe gastroduodenal cytoprotective potential was evaluated in rodent experimental models (HCl/Ethanol and NSAID-induced ulcer protocols). The anti-H. pylori property was assessed by agar dilution assay in vitro and analysis in vivo including rapid urease test, immunogold test and histopathology. For toxicity assessment, acute toxicity study was performed according to fixed dose procedure with a single oral administration of HZJW to mice. In the oral chronic toxicity, rats (80 males, 80 females) were administrated HZJW orally in 0, 1000, 2500, or 5000 mg/kg/day doses for 26 weeks (n = 40/group of each sex). Clinical signs, mortality, body weights, feed consumption, ophthalmology, hematology, serum biochemistry, gross findings, organ weights and histopathology were examined at the end of the 13- and 26-week dosing period, as well as after the 4-week recovery period.ResultsIn the HCl/Ethanol-induced ulcer model, it was observed that oral administration with HZJW (260, 520 and 1040 mg/kg) and ranitidine (250 mg/kg) significantly reduced the ulcerative lesion index (116.70 ± 36.4, 102.20 ± 18.20, 84.10 ± 12.1 and 73.70 ± 16.70) in a dose-dependent manner, respectively, with respect to control group (134.10 ± 31.69). Significant inhibition was also observed in ulcerative index from aspirin-induced ulcer model, with decreases of 35.40 ± 5.93, 31.30 ± 8.08, 26.80 ± 8.27and 20.40 ± 6.93 for the groups treated with HZJW and ranitidine, in parallel to controls (41.60 ± 10.80). On the other hand, treatment with HZJW efficaciously eradicated H. pylori in infected mice in rapid urease test (RUT) and immunogold antibody assay, as further confirmed by reduction of H. pylori presence in histopathological analysis. In the in vitro assay, MICs for HZJW and amoxicillin (positive control) were 125 and 0.12 μg/mL respectively. The LD50 of HZJW was over 18.0 g/kg for mice. No drug-induced abnormalities were found as clinical signs, body weight, food consumption, hematology, blood biochemistry, ophthalmology and histopathology results across three doses. No target organ was identified. The No Observed Adverse Effect Level (NOAEL) of HZJW was determined to be 5,000 mg/kg/day for both sexes, a dose that was equivalent to 50 times of human dose.ConclusionsThese results suggested the efficacy and safety of HZJW in healing peptic ulcer and combating H. pylori, which corroborated their conventional indications and contributed to their antiulcer pharmacological validation, lending more credence to its clinical application for the traditional treatment of stomach complaints symptomatic of peptic ...

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Anti-Helicobacter pylori Diarylheptanoid Identified in the Rhizome of Alpinia officinarum

Cited by 14 publications

References 18 publications

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Natural Products for the Prevention and Management of Helicobacter pylori Infection

Diarylheptanoids as nutraceutical: A review

Gastroprotective and anti-Helicobacter pylori potential of herbal formula HZJW: safety and efficacy assessment

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