Anti-Hu-Associated Paraneoplastic Encephalomyelitis/Sensory Neuronopathy A Clinical Study of 71 Patients

Dalmau, Josep; Graus, Francesc; Rosenblum, Marc K.; Posner, Jerome B.

doi:10.1097/00005792-199203000-00001

Cited by 774 publications

(569 citation statements)

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“…Similar to SEREX, our approach offers the potential of identifying tumor-specific antigens. Some degree of tumor specificity is also suggested by the reports of seropositivity for type 1 antineuronal nuclear autoantibodies (ANNA-1, also know as anti-Hu), which is considered a valuable marker of small cell lung carcinoma (8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

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Antinuclear Antibodies as Potential Markers of Lung Cancer

Fernandez-Madrid

VandeVord

Yang

et al. 2000

Cancer and Autoimmunity

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Section: Discussionmentioning

confidence: 99%

“…differentiation antigens (7). Other studies have looked for antigens specific for a certain type of malignancy (3,(8)(9)(10)(11). It is possible that the many tumor antigens may not be absolutely specific to the type of tumor, but may be expressed in other related malignant cells as well.…”

Section: Introductionmentioning

confidence: 99%

Antinuclear Antibodies as Potential Markers of Lung Cancer

Fernandez-Madrid

VandeVord

Yang

et al. 2000

Cancer and Autoimmunity

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“…This finding adds to earlier reports describing non-classical neuroectodermal tumors associated with humoral anti-Hu immunity. 28,42 However, since tumor tissue from the anti-Hu positive patient with B cell lymphoma was not available, the postulated tissue expression of Hu antigens could not be examined.…”

Section: Table IV -Mrna Expression Of Hud and Nnp1 5јvariants And Hucmentioning

confidence: 99%

Novel products of the HUD, HUC, NNP‐1 and α‐internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library

Behrends

Jandl

Golbeck

et al. 2002

Intl Journal of Cancer

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Autologous serological screening of a cDNA expression library (SEREX) derived from childhood neuroblastoma led to the identification of 10 different antigens, including 6 novel gene products. The novel antigen 018INX was derived from a small open reading frame in a region of ␣-internexin mRNA that was previously described as 3 untranslated region. 018INX thus represents a novel type of tumor antigen. Five novel gene products were derived from NNP-1 (NNP3) and Hu genes (HuC-L, HuD3, HuDY, HuD1pro c ). As indicated by sequence analysis, these antigens were generated by alternative splicing and/or alternative promoter usage or allelic polymorphism. mRNA expression analyses revealed different tissue restrictions of novel compared to known HuD and NNP-1 transcripts in normal and malignant tissues. The expressions patterns of distinct transcripts indicated potential clinical meanings as diagnostic and/or prognostic tissue markers. When kinetics of serum antibody titres against SEREX-defined antigens were compared to tumor load over time in our patient with neuroblastoma, we found 100-fold increases of anti-Hu and anti-018INX antibody titres preceding the clinical diagnosis of recurrent tumor growth after 2 years. When sera of pediatric patients with cancer (30) and healthy controls (30) were tested for humoral responses to SEREX-defined neuroblastoma antigens, we detected antibodies against all known antigens and NNP3 with low frequencies and titres in control sera, while anti-018INX and anti-Hu antibodies were found in cancer patients only. Our findings indicate that SEREX-defined tumor antigens might provide novel tools for understanding and treatment of this aggressive childhood malignancy.

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“…8 In their paper Dalmau proposed that an immune reaction against still unknown antigens could precipitate mental neuropathy. 17 Accurate localisation of the area of numbness can point to whether the nerve involvement is central or peripheral. Accurate history is equally important in determining the cause.…”

Section: Discussionmentioning

confidence: 99%