Anti-inflammatory Action of Calorie Restriction Underlies the Retardation of Aging and Age-Related Diseases

Abstract

Calorie restriction (CR) is known to extend lifespan and has anti-oxidative properties that lead to physiological and biological resistance against diseases and stress. This chapter reviews the molecular mechanisms of CR's anti-inflammatory actions during aging. The crux of CR's ability to attenuate age-related chronic inflammation is related to its power to maintain redox status by modulating oxidative stress during aging. Here, for better molecular insights, key transcription factors such as FoxO, Nrf2, and PPARs induced by CR are described for their modulation of the age-related inflammation response. In addition, recent analyses by systems biology on chronic inflammation, age-related pro-inflammatory gene activation, and CR's suppression produced evidence identifing various target genes, target molecules, and their networks. The wide implication of the proinflammatory process under

Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

“…Calorie restriction (CR) is a commonly used FR strategy that restricts everyday energy intake without incurring malnutrition [ 4 ]. In experimental animal models, appropriate CR has been shown to have benefits including elongation of life span [ 5 ], promotion of weight loss [ 6 , 7 , 8 ], suppression of inflammation [ 9 , 10 , 11 ], cardiovascular disease risk reduction [ 12 , 13 , 14 ], and cancer prevention [ 2 , 15 ]. Notwithstanding these benefits, there are still concerns when applying CR, such as poor CR compliance [ 16 ].…”