Anti-Inflammatory Activities of Hot Water Extracts of Petasites japonicus Leaves in LPS-Induced RAW264.7 Cells

김은진,; 김한나,; 김해미,; 박상수,

doi:10.3746/jkfn.2020.49.3.289

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Maxim. is not poisonous and that it is good to boil the stems to make soup or to eat as a side dish of herbs [ 12 ]. Among the various active ingredients present in P. japonicus (Siebold & Zucc.)…”

Section: Introductionmentioning

confidence: 99%

“…Among the various active ingredients present in P. japonicus (Siebold & Zucc.) Maxim., caffeic acid, 3-O-caffeoylquinic acid, fukinolic acid in flowers, and petasinophenol, flavonoid glycosides, phenylprophenoyl sulfonic acid, and fukinolic acid in leaves were detected as antioxidant compounds [ 11 , 12 , 13 ]. In addition, sesquiterpene esters such as petasin and s-petasin, which have anti-asthmatic and anti-allergic effects in leaves, backkenolide B, and petatewalide B with anti-allergic and anti-inflammatory effects in leaves were isolated [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Short-Term Effects of PJE Administration on Metabolic Parameters in Diet-Induced Obesity Mice

Choi

Kim

Park

et al. 2023

Foods

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The study investigated the effects of Petasites japonicus (Siebold & Zucc.) Maxim. extract (PJE) and fenofibrate on diet-induced obesity (DIO) in mice. PJE was found to contain various bio-active polyphenolic compounds, including kaempferol, p-hydroxybenzoic acid, ferulic acid, gallic acid, chlorogenic acid, 3,4-dicaffeoylquinic acid, caffeic acid, quercetin, rutin, protocatechuic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid, p-coumaric acid, apigenin, and 1,3-dicaffeoylquinic acid. The results showed that PJE treatment up to 1000 μg/mL did not affect the viability of 3T3-L1 cell line, and it reduced the feed efficiency ratio in DIO mice. PJE administration also resulted in a significant reduction in body weight gain and fat accumulation in the liver compared to the DIO control group. Additionally, PJE administration improved the levels of lipid and related parameters, including total cholesterol, triacylglycerol, low-density lipoprotein, very low-density lipoprotein, glucose, insulin, insulin resistance, leptin, and atherogenic or cardiac indexes compared to the DIO control group. The study suggested that PJE may have a beneficial effect on insulin resistance, lipid profiles, atherogenesis, adipokines, and cardiac risk associated with diet-induced obesity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short-Term Effects of PJE Administration on Metabolic Parameters in Diet-Induced Obesity Mice

Choi

Kim

Park

et al. 2023

Foods

View full text Add to dashboard Cite

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A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

Kulinowski

Luca

Minceva

et al. 2022

Journal of Ethnopharmacology

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Nutritional components and physiological activities of Petasites japonicus solvent extracts

Eom¹,

Jeong²,

Kwon³

et al. 2021

Korean J. Food Preserv.

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Petasites japonicus (PJ) has been used traditionally as the treatment or the prophylaxis of migraine and tension headache in Asia. In the present study, to we compared the characteristics of PJ powder and extracts obtained by various methods utilize the PJ as a functional material. PJ powder by freeze-drying possessed 6.61% water content, 4.51% crude fat, 23.75% crude protein, 18.62% crude ash, 46.97% carbohydrates, and crude fiber 39.22%. It contained a particularly high potassium content in mineral. Among different extraction methods, extracts of 50% (PJ-50E) or 70% ethanol (PJ-70E) showed the highest total polyphenol content and antioxidant activity, while cold-water extraction (PJ-WE) showed the lowest. However, when the α-glucosidase inhibitory were analyzed, PJ-WE was highest while the treatment extracted ethanol were not active at all. In anti-inflammatory activity by RAW 264.7 and HaCaT cells, PJ-WE showed significantly higher inhibitory activity in comparison to those of the other extract. In conclusion, it is considered that the water-extraction method is better than other extraction methods for practical preparation of functional materials with high α-glucosidase inhibitory and anti-inflammatory activities from PJ.

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Anti-Inflammatory Activities of Hot Water Extracts of Petasites japonicus Leaves in LPS-Induced RAW264.7 Cells

Cited by 3 publications

References 8 publications

Short-Term Effects of PJE Administration on Metabolic Parameters in Diet-Induced Obesity Mice

Short-Term Effects of PJE Administration on Metabolic Parameters in Diet-Induced Obesity Mice

A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)

Nutritional components and physiological activities of Petasites japonicus solvent extracts

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