Anti-inflammatory activity of fisetin in human mast cells (HMC-1)

Ravula

Can. J. Physiol. Pharmacol.

et al. 2017

This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular dementia (VaD) in rats. Wistar rats were randomly divided into 8 groups: control, vehicle control, l-methionine, FST (5, 10, and 25 mg/kg, p.o.), FST-per se (25 mg/kg, p.o.), and donepezil (0.1 mg/kg, p.o.). l-Methionine administration (1.7 g/kg, p.o.) for 32 days induced HHcy. ED and VaD induced by HHcy were determined by vascular reactivity measurements, behavioral analysis using Morris water maze and Y-maze, along with a biochemical and histological evaluation of thoracic aorta and brain tissues. Administration of l-methionine developed behavioral deficits; triggered brain lipid peroxidation (LPO); compromised brain acetylcholinesterase activity (AChE); and reduced the levels of brain superoxide dismutase (SOD), brain catalase (CAT), brain reduced glutathione (GSH), and serum nitrite; and increased serum homocysteine and cholesterol levels. These effects were accompanied by decreased vascular NO bioavailability, marked intimal thickening of the aorta, and multiple necrotic foci in brain cortex. HHcy-induced alterations in the activities of SOD, CAT, GSH, AChE, LPO, behavioral deficits, ED, and histological aberrations were significantly attenuated by treatment with fisetin in a dose-dependent manner. Collectively, our results indicate that fisetin exerts endothelial and neuroprotective effects against HHcy-induced ED and VaD.

mentioning

confidence: 99%

Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia

Ravula

Can. J. Physiol. Pharmacol.

et al. 2017

“…Fisetin, quercetin, and rutin decreased gene expression and production of all the proinflammatory cytokines after PMACI stimulation. Fisetin inhibited PMACI-induced phosphorylation of p38 mitogen-activated protein kinase, extracellular-regulated kinase, and c-Jun N-terminal kinase [26]. Myricetin attenuated TNF-alpha and IL-6 but not IL-1beta and IL-8.…”

Section: Introductionmentioning

confidence: 85%

Polyphenols and their Mechanism of Action in Allergic Immune ResponseImmune Response

Juríková¹

2015

Glob J Allergy

Mini review article deals with the most studied group of chemical compounds -polyphenolspredominantly flavonoids in relation to their allergic immune response. There is clarified and discussed their mechanism of action as well. We emphasized on the strongest inhibitors of allergic reactions -luteolin, fisetin and apigenin, but in the second part the currently studied flavonoids have been summarized as well. The interaction of polyphenols with proteins can modulatethe process of allergic sensitization and their direct effect on allergic effector cells, such as mast cells, inhibits mediator release, resulting in the alleviation of symptoms 3. Endogenous anti-oxidant ability can limit the extent of cellular injury from free radicals during any reaction [12].

Iran Red Crescent Med J

“…Hajhashemi et al (8) conducted a study on rats and mice, revealing the anti-inflammatory effects of S. hortensis and confirming the findings of this study regarding the attenuation of hs-CRP. In addition to free radical scavenging during over production of reactive substances in inflammation, flavonoids can inhibit the release of histamine and expression of pro-inflammatory cytokines (28,29). Carvacrol, one of the main components of Satureja species, was found to be a potent suppressor of expression of cyclooxygenase-2, which is a key enzyme for inflammation cascade initiation (30).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Satureja hortensis L. Dried Leaves on Serum Sugar, Lipid Profiles, hs-CRP, and Blood Pressure in Metabolic Syndrome Patients: A Double-Blind Randomized Clinical Trial

Nikaein

Babajafari

Mazloomi

et al. 2016

Background: Metabolic syndrome, which includes multiple metabolic disorders in an individual, has a direct relationship with incidence of various heart diseases. Satureja hortensis L. has been considered to treat this syndrome because its active compounds have valuable therapeutic effects, including anti-inflammatory, antihyperglycemic, vasodilator, and antihyperlipidemic properties as well as being antioxidants and free radical scavengers.