Anti-Inflammatory Activity of Flavonol Glycosides from<i>Erythrospermum monticolum</i>Depending on Single or Repeated Local TPA Administration

Recio, M. C.; Giner, Rosa M.; Máñez, Salvador; Talens, Amparo; Cubells, Laura; Guého, Joseph; Julien, H. R.; Hostettmann, Kurt; Rı́os, José-Luis

doi:10.1055/s-2006-959357

Cited by 24 publications

(8 citation statements)

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“…Out of these phytoconstituents, polyphenols and flavonoids have been well known to exhibit anti-inflammatory and antinociceptive action [29–31]. These flavonoids may interact directly with the prostaglandin system and inhibit the substitute cofactor for the prostaglandin generation and also inhibit arachidonate lipoxygenation as well as enzymes involved with inactivation or biotransformation of prostaglandins [32, 33]. In the present work, flavonoids were quantified.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

Bhadoriya¹

2012

Sci. Pharm.

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The present study aimed to investigate the anti-inflammatory and anti-nociceptive potential of a hydroethanolic extract of Tamarindus indica L. leaves (HTI) along with its possible mode of action. The anti-inflammatory activity of HTI was estimated by carrageenan-induced hind paw oedema in male Wistar albino rats. Furthermore, HTI was assessed to determine its effects on membrane stabilization. The antinociceptive action was determined by acetic acid-induced writhing, tail-flick, and the hot plate model. Oral administration of HTI at the dose of 500, 750, and 1000 mg/kg body weight produced significant (P< 0.01) anti-inflammatory as well as antinociceptive actions in a dose-dependent manner. Among all tested doses, 1000 mg/kg, p. o. reduced carrageenan-induced rat paw oedema at 1, 2, 3, and 4 h. Moreover, the 1000 mg/kg dose exhibited maximum percentage inhibition of acetic acid-induced writhing (48.9%), whereas standard drug diclofenac (25 mg/kg, p. o.) showed maximum inhibition (50.9%) of writhing. In the hot plate model, HTI (1000 mg/kg, orally) increased mean basal reaction time after 120 min (7.12±0.05 sec). In the tail flick model, HTI increased the maximum percentage of latency (36.06%), whereas the standard drug pethidine (4 mg/kg, intraperitoneally) showed maximum percentage of latency (43.85%) after 60 min. The findings of the present study supported anti-inflammatory and antinociceptive claims of T. indica as were mentioned in Indian traditional and folklore practices.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

Bhadoriya¹

2012

Sci. Pharm.

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“…It seems that steroids available in the plant extract inhibit production of prostaglandins reducing inflammation by inhibiting cyclooxygenase. 28 In studies conducted on aqueous extract of Teucrium hyrcanicum in male mice and rats, analgesic and anti-inflammation effects of extract have been attributed to alkaloid, flavonoid, and triterpenoids compounds and central and peripheral mechanisms have been stated as responsible for these effects. 29…”

Section: Discussionmentioning

confidence: 99%

The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice

Rafieian-Kopaei

Shakiba

Sedighi

et al. 2017

J Evid Based Complementary Altern Med

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Linum usitatissimum L is traditionally used for relief of pain and inflammation. In this study, the analgesic and anti-inflammatory effects of this plant were evaluated. Xylene test was used for anti-inflammatory evaluation in which 48 mice were randomly designated into 6 groups of 8 each including: control, dexamethasone as positive control (15 mg/kg), and experimental groups (42, 85, 170, and 340 mg/kg, respectively). For analgesic evaluation, 192 mice were randomly designated into 4 sets of 6 groups of 8 mice, including control, morphine as positive control, morphine plus naloxone, experimental groups (200 and 500 mg/kg extract), and extract along with naloxone group, which received 500 mg/kg. The analgesic activities were evaluated at 5, 15, 30, and 60 minutes, respectively, in each set. Both doses showed analgesic activity, the 200 mg/kg possessed higher effects (P < .05). Naloxone reduced a section of its effect (P < .001). The 170 mg/kg dose of the extract showed anti-inflammatory activity (P < .05). The extract had phenolic, flavonoid, and flavonol compounds with antioxidant activity. Linum usitatissimum L dose dependently had analgesic activity partially like morphine and might be used as analgesic and anti-inflammatory agent.

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“…40,41 These flavonoids may interact directly with the prostaglandin system and inhibit the substitute cofactor for the prostaglandin generation and also inhibit arachidonic acid lipoxygenation as well as enzymes involved with inactivation or biotransformation of prostaglandins. 42,43 Tannins have astringent properties which are important in wound healing. 44 There are also reports on the role of tannins in anti-nociceptive activity.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial, Analgesic and Anti - Inflammatory Activity Reported on Tamarindus indica Linn Root Extract

Gupta¹,

Singh²

2017

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Anti-Inflammatory Activity of Flavonol Glycosides fromErythrospermum monticolumDepending on Single or Repeated Local TPA Administration

Cited by 24 publications

References 1 publication

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

Anti-Inflammatory and Antinociceptive Activities of a Hydroethanolic Extract of Tamarindus indica Leaves

The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice

Antimicrobial, Analgesic and Anti - Inflammatory Activity Reported on Tamarindus indica Linn Root Extract

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