Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models

Gupta, Malaya; Mazumder, Upal Kanti; Kumar, Rajesh; Gomathi, P.; Yerra, Rajeshwar; Kakoti, Bibhuti Bhusan; Selven, V. Tamil

doi:10.1016/j.jep.2005.01.018

Cited by 151 publications

(112 citation statements)

References 17 publications

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“…At the doses of 300 mg/kg and 2,000 mg/kg, mice did not present weight loss or death. LD 50 cut-off of CrataBL was determined as 2,500 mg/kg body weight, resulting in both concentrations used being considered as safe (Category 5) 14 . (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

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Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Araújo

Vaz

Aguiar

et al. 2011

Nat. Prod. Bioprospect.

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Abstract:Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice. The antiinflammatory and analgesic properties were investigated in models of inflammation and nociception. The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response. The lectin presents low toxicity with a LD 50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth. The lectin also promoted significant reduction (35.4%) in the number of neutrophil migration induced by carrageenan. Concerning its analgesic property, the lectin inhibits abdominal contractions induced by acetic acid. The current results revealed a lectin with significant antitumoral, anti-inflammatory and antinociceptive activities. Further investigations to unveil the exact mechanisms are needed.

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Section: Resultsmentioning

confidence: 99%

“…After 1 h, 0.25 ml carrageenan (1% in saline solution) injected intraperitoneally was used as a phlogistic agent. After 4 h the animals were sacrificed by cervical dislocation and immediately submitted to surgery for abdominal opening 14 . The peritoneal cavity was washed with 2 ml of saline solution with EDTA.…”

Section: Animalsmentioning

confidence: 99%

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Araújo

Vaz

Aguiar

et al. 2011

Nat. Prod. Bioprospect.

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“…The percentage inhibition of the inflammation was calculated from the formula: % inhibition=D 0 -D t /D 0 x100 where D 0 was the average inflammation (hind paw oedema) of the control group of rats at a given time; and D t was the average inflammation of the drug treated (i.e. extracts or reference indomethacin) rats at the same time (Gupta et al 2005, Sawadogo et al 2006, Moody et al 2006). …”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo¹,

Sofidiya²,

Afolayan³

2008

RBT

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Abstract:Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. Rev. Biol. Trop. 57 (4): 1193-1200. Epub 2009 December 01.

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“…Any agent showing antiinflammatory response on chronic inflammation has an ability to inhibit the increase in number of fibroblasts during granular tissue formation. 20 HEPBL demonstrated a decrease in the weight of the granuloma and thereby demonstrating its anti-proliferative effect in chronic inflammation. Preliminary qualitative phytochemical study revealed the presence of flavonoids, phenols, glycosides and tannins in HEPBL.…”

Section: Discussionmentioning

confidence: 90%

Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

Reddy

Gupta

Reddy

2016

Int J Basic Clin Pharmacol

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Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models

Cited by 151 publications

References 17 publications

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

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