Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules

Abstract

: Osteoarthritis and rheumatoid arthritis are the most common diseases of the musculoskeletal system, which greatly reduce the quality of life of people. In addition to non-steroidal anti-inflammatory drugs used in treatment, molecules isolated from natural sources are also considered as new options in the treatment of these inflammatory diseases. In this review, in vitro, in vivo and clinical studies on standardized rosehip (Rosa canina L.) fruits without seed used for joint health due to their anti-inflammatory, analgesic and antioxidant effects and active compounds isolated from these fruits are presented. It is reported that the anti-inflammatory action mechanism of standardized rosehip powder is due to its antioxidant activity, inhibiting NF-B signaling, inhibiting pro-inflammatory enzymes, decreasing inflammatory cytokine and chemokine production, and lowering C reactive protein levels. The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-ß-D-galactopyranosyl glycerol (GOPO), isolated from rosehip seeds and fruits, has been found to exhibit potent anti-inflammatory effects in vitro, clinically reducing the complaints of patients with osteoarthritis and improving their quality of life. Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-α. Conclusion: Studies on the anti-inflammatory mechanism of action of rosehip and its active ingredients and their effects on osteoarthritis and rheumatoid arthritis have shown that more detailed clinical studies are required on standardized rosehip powders and preparations enriched in active compounds.

NSAID Treatment Before and on the Early Onset of Acute Kidney Injury Had an Opposite Effect on the Outcome of Patients With AKI

“…NSAIDs were best known for inhibiting cyclooxygenases, which produce prostaglandins and thromboxanes. Its anti-inflammatory effects extend far beyond cyclooxygenase inhibition, including the inhibition of the pivotal nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and the induction of certain types of eicosanoids, which reduced pro-inflammatory mediators such as TNF-, IL-1, and IL-6 ( Deligiannidou et al, 2021 ; Pekacar et al, 2021 ; Ladd et al, 2022 ).…”

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

“…However, the commonly used anti-inflammatory drugs will have some side effects during the treatment [145,146]. Therefore, in addition to using traditional non-steroidal anti-inflammatory drugs to treat inflammation, some compounds isolated from natural sources are also considered new options for treating inflammatory diseases [147][148][149][150]. Among these, some natural sesquiterpenes obtained from the Artabotrys genus have demonstrated promising anti-inflammatory and analgesic activities.…”

Screening and classification of rosehip (Rosa canina L.) genotypes based on horticultural characteristics

“…Rosehip fruits are rich in vitamins, minerals polyphenols, and organic acids, which have antioxidant effects [ 6 – 8 ]. These antioxidants positively influence the treatment of many cardiovascular, respiratory, and chronic diseases, infections, etc [ 9 – 11 ].Due to these reasons, it is integrated into the industry in different forms such as marmalade, jam, vinegar, and different parts for instance seeds or fruit flesh are used to enrich the benefits of the products or to extend their shelf life as food additives [ 12 , 13 ].…”