Anti-inflammatory and analgesic properties of Ocimum sanctum: a comparative study using animal models

Umamageswari, A.; Kudagi, B. L.

doi:10.18203/2319-2003.ijbcp20150878

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…This injection generated intense inflammation, which peaked after 3 hours. These results correlate with previous studies showing that 3 hours after the carrageenan injection is the moment when its maximum effect is manifested and the moment when the anti-inflammatory activity of the test product is best observed [29]. The experimental data showed that PLFO presented a significant ( p < 0.01) paw edema inhibition which was more important than that of the standard Inflocine (reference drug) and Carr group.…”

Section: Discussionsupporting

confidence: 89%

In Vivo Evaluation of the Anti‐Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress

Khedir

Mzid

Bardaa

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant. This work was designed to determine the topical anti-inflammatory effect of Pistacia lentiscus fruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress. The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval. After that the rats were scarified and the inflamed paw tissue was removed for the exploration of some parameters of oxidative stress and histopathology. PLFO showed a significant anti-inflammatory activity in comparison with the Inflocine. The percentages of edema inhibition were 70% and % 51.5% (p < 0.01), respectively, after five hours. The treatment with PLFO and Inflocine led to significant increases (p ≤ 0.05) in the activities of CAT, SOD, and GPX and significant decreases in the MDA level and AOPP activity in the paw tissue after Carr injection, in comparison with the Carr group. Therefore, our findings demonstrate that PLFO might accelerate the development of new drugs which could be used scientifically as a source for natural health products in the treatment of topical inflammation.

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Section: Discussionsupporting

confidence: 89%

In Vivo Evaluation of the Anti‐Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress

Khedir

Mzid

Bardaa

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…The aqueous extract of O. sanctum (100 mg/kgBW) was tested for antiinflammatory and analgesic activity in rats, and the percent inhibition of O. sanctum was 23.85%. It is suspected that the compound in O. sanctum that acts as an analgesic is eugenol, which is abundant in O. sanctum leaves, is suspected to act as an analgesic (Umamageswari & Kudagi, 2015). The analgesic mechanism of O. sanctum may involve antagonizing prostanoid receptors or inhibiting the synthesis of prostaglandins (Kumar et al, 2011).…”

Section: Antioxidant Activity Test Resultsmentioning

confidence: 99%

ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT

Amelia,

Falya,

Tomi

et al. 2023

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Natural deep eutectic solvents (NaDES) are obtained from an adequate mixture of hydrogen bond acceptors (HBA) and donors (HBD), which can bond through the interaction of hydrogen bonds to form a eutectic with a low melting point. NADES has been implemented in several studies as an effective extraction method, but it is still not widely used. C. papaya leaves and O. sanctum leaves have been widely known to have various pharmacological activities. The aim of this study was to determine the best analgesic ability of the NADES extract of C. papaya and O. sanctum leaves. The extraction process used was Microwave-Assisted Extraction (MAE). The liquid extract was tested for antioxidant activity and analgesic activity using doses of 600 mg/kgBW, 800 mg/kgBW, and 1000 mg/kgBW. The results show that The IC50 values of the NADES extract of C. papaya and O. sanctum leaves were 920 ppm and 882 ppm, respectively. Both analgetic percentages are equivalent to the positive control starting from a concentration of 800 mg/kgBW, where the analgetic percentage of the NADES extract of papaya leaves and basil leaves is 59.80% and 54.57% respectively that included in weak category. It can be concluded that both NADES extracts of papaya and basil leaves have analgetic capabilities. Keywords: Natural Deep Eutectic Solvent (NADES), Carica papaya, Ocimum sanctum, analgetic activity.

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“…Analgesic drugs prolong the reaction time of the response provoked by immersing the tail end in warm water. It has been established that if a substance increases response time, such substance must be acting centrally through the opioid receptor [26]. It has been reported that recurring stimuli augment the reaction of an animal to a particular injurious stimulus [27].…”

Section: Discussionmentioning

confidence: 99%

Anti-nociceptive effect of gabapentin in mouse models of acute and chronic pain

Vasudevan¹,

Batool²,

Kandasamy³

et al. 2021

Trop. J. Pharm Res

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Purpose: To investigate the anti-nociceptive effect of gabapentin in acute and chronic pain models. Methods: Four mouse models of pain were used in this study. These comprised thermal tests (hot plate and tail immersion tests), and chemical tests (formalin and acetic acid-induced writhing tests). A total of seventy-two (72) albino mice weighing 25 - 40 g (mean weight = 32.5 ± 5.1 g) were used. In each test, the mice were randomly assigned to three sets of 6 mice each: control group, celecoxib group and drug treatment group. Each test was performed at intervals of 30, 60 and 90 min. Results: During the acute phase, there was no significant decrease in foot raising (FR) or licking and biting (L & B) episodes among the groups (p > 0.05). However, these episodes were significantly (p < 0.05) decreased in the second delayed phase, in the celecoxib and drug-treated groups, when compared with normal control group. Gabapentin significantly (p < 0.05) decreased pain response throughout the course of the thermal tests. The number of writhes within 30 min were significantly reduced in celecoxib and gabapentin-treated animals, compared with negative control group (p < 0.05). Gabapentin produced approximately 60 % protection of writhing, similar to that produced by celecoxib, the standard non-steroidal anti-inflammatory drug (NSAID) used (61 %). Conclusion: The results demonstrate that the gabapentin is effective against chronic inflammatory pain in mice and therefore can be potentially developed as an effective anti-inflammatory agent for humans.

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Anti-inflammatory and analgesic properties of Ocimum sanctum: a comparative study using animal models

Cited by 9 publications

References 8 publications

In Vivo Evaluation of the Anti‐Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress

In Vivo Evaluation of the Anti‐Inflammatory Effect of Pistacia lentiscus Fruit Oil and Its Effects on Oxidative Stress

ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT

Anti-nociceptive effect of gabapentin in mouse models of acute and chronic pain

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