Anti-inflammatory and angiogenic activity of polysaccharide extract obtained from Tibetan kefir

Prado, Maria Rosa Machado; Boller, Christian; Mello, Rosiane Guetter; Souza, Daiany de; Pedroso, Fiona L.; Soccol, Carlos Ricardo

doi:10.1016/j.mvr.2016.07.004

Cited by 44 publications

(29 citation statements)

References 27 publications

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“…Several studies have highlighted that kefir has the potential to treat diseases such as cancer (Hatmal et al, 2018;Melo et al, 2018;Topuz et al, 2008), gastritis (Akal et al, 2018;Bekar et al, 2011;Yamane et al, 2018), tumors (Yamane et al, 2018), inflammations (Rodrigues et al, 2016), and infections (Iraporda et al, 2017;Burlando & Cornara, 2017;Spinler et al, 2016;Prado et al, 2016). In regenerative medicine, kefir is given special attention as a biocurative for the skin (Gonçalves et al, 2019;Gonçalves et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Stereometric characterization of kefir microbial films associated with Maytenus rigida extract

Matos

Pinto

Ramos

et al. 2020

Microscopy Res & Technique

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The aim of this study was to report the first discussion of statistical parameters and possible applications related to the surface of kefir biofilms prepared with Maytenus rigida Mart. extract through micromorphology, using atomic force microscopy (AFM). Four different samples were produced. The reference contained demerara sugar with a concentration of 40 g/L and the others had added extract whose concentrations were 0.25, 0.50, and 0.75 g/L, respectively. AFM was used to image the surface in tapping mode, on square areas of 30 μm × 30 μm. Images were studied by the MountainsMap premium commercial software. The main parameter of the surface, roughness, grew with the increase of the extract concentration up to 0.50 g/L. In addition, asymmetry and kurtosis showed that the biofilm with the best peak distribution was the one with 0.25 g/L of plant extract. The other parameters followed the main results for the surface and were observed for the depth and volume parameters. The power spectrum density spectrum confirmed the reliability of the results for the sample with 0.25 g/L. Therefore, the sample with 0.25 g/L of plant extract produced the best balance in relation to the surface properties. These results showed that the biofilm morphology and microtexture were affected by the incorporation of the plant extract and can be useful to define possible applications.

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Section: Introductionmentioning

confidence: 99%

Stereometric characterization of kefir microbial films associated with Maytenus rigida extract

Matos

Pinto

Ramos

et al. 2020

Microscopy Res & Technique

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“…Kefir grains contain a natural microbial consortium composed of a diverse and stable community of bacterial and yeast species [15,16] embedded in an exopolysaccharide matrix called kefiran [17]. Several studies have demonstrated that the microbes present in kefir are probiotic have beneficial health properties, including antibiosis [18], hypocholesterolaemic [19], antihypertensive [20], and anti-inflammatory [21] effects, as well as antioxidant [22], and anti-carcinogenic activity [23].…”

Section: Introductionmentioning

confidence: 99%

Yeasts and Bacterial Consortia from Kefir Grains Are Effective Biocontrol Agents of Postharvest Diseases of Fruits

et al. 2020

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Fungal pathogens in fruits and vegetables cause significant losses during handling, transportation, and storage. Biological control with microbial antagonists replacing the use of chemical fungicides is a major approach in postharvest disease control, and several products based on single antagonists have been developed but have limitations related to reduced and inconsistent performance under commercial conditions. One possible approach to enhance the biocontrol efficacy is to broaden the spectrum of the antagonistic action by employing compatible microbial consortia. Here, we explore commercial kefir grains, a natural probiotic microbial consortium, by culture-dependent and metagenomic approaches and observed a rich diversity of co-existing yeasts and bacterial population. We report effective inhibition of the postharvest pathogen Penicillium expansum on apple by using the grains in its fresh commercial and milk-activated forms. We observed few candidate bacteria and yeasts from the kefir grains that grew together over successive enrichment cycles, and these mixed fermentation cultures showed enhanced biocontrol activities as compared to the fresh commercial or milk-activated grains. We also report several individual species of bacteria and yeasts with biocontrol activities against Penicillium rots on apple and grapefruit. These species with antagonistic properties could be further exploited to develop a synthetic consortium to achieve enhanced antagonistic effects against a wide range of postharvest pathogens.

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“…During the last decade, bacterial EPSs have been reported with different biological activities such as lowering blood cholesterol level, antioxidation, anticancer and immunoregulation [5,6]. These bioactivities of EPS were found to closely relate to its monosaccharide composition, molecular weight, conformation and glycosidic linkage [7]. EPSs with helix structure and higher molecular mass possessed higher anti-inflammatory activity [8].…”

mentioning

confidence: 99%

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

Zhao¹,

Zhang²,

Jiang³

et al. 2018

Journal of Microbiology and Biotechnology

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The exopolysaccharide (EPS) produced by Bacillus amyloliquefaciens GSBa-1 was isolated and purified by ethanol precipitation, DEAE-cellulose and Sepharose CL-6B chromatography. The molecular weight of the purified EPS was determined to be 54 kDa. Monosaccharide analysis showed that the EPS was composed of predominantly glucose, and it was further confirmed by NMR spectroscopy to be α-glucan consisted of a trisaccharide repeating unit with possible presence of two α-(1→3) and one α-(1→6) glucosidic linkages. Microstructural analysis showed that the EPS appeared as ellipsoid or globose with smooth surface. The EPS had a degration temperature at 240℃. Furthermore, the EPS had strong DPPH and hydroxyl radical scavenging activities, and moderate scavenging activities on superoxidant anion and metal ion chelating activity. This is the first characterization of a glucan produced by B. amyloliquefaciens with strong antioxidant activity. The results of this study suggested the potential of the EPS from B. amyloliquefaciens GSBa-1 to serve as a natural antioxidant for application in functional products.

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Anti-inflammatory and angiogenic activity of polysaccharide extract obtained from Tibetan kefir

Cited by 44 publications

References 27 publications

Stereometric characterization of kefir microbial films associated with Maytenus rigida extract

Stereometric characterization of kefir microbial films associated with Maytenus rigida extract

Yeasts and Bacterial Consortia from Kefir Grains Are Effective Biocontrol Agents of Postharvest Diseases of Fruits

Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1

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