Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound β-caryophyllene in in vivo models

Oliveira-Tintino, Cícera Datiane de Morais; Pessoa, Renata Torres; Fernandes, Maria Neyze Martins; Alcântara, Isabel Sousa; Silva, Bruno Anderson Fernandes da; Oliveira, Maria Rayane Correia de; Martins, Anita Oliveira Brito Pereira Bezerra; Silva, Maria do Socorro da; Tintino, Saulo Relison; Rodrigues, Fábio Fernandes Galvão; Costa, José Galberto Martins da; Lima, Sidney Gonçalo de; Kerntopf, Marta Regina; Silva, Teresinha Gonçalves da; Menezes, Irwin Rose Alencar de

doi:10.1016/j.phymed.2018.02.004

Cited by 54 publications

(30 citation statements)

References 109 publications

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“…This virtual approach has revealed that the inhibitory enzymatic action is related to the structural affinity of XO and E-caryophyllene [34]. This is consistent with the foregoing [38] experimental publications. Innovative and Clinical Possibilities for H. obtusiflora Use and Conservation under the Nagoya Protocol…”

Section: Resultssupporting

confidence: 82%

“…The biological applications of some of the components isolated from close species are well known as anti-inflammatories or antinociceptives in several cases. Thus, 1,8-cineole has shown therapeutic benefits in inflammatory diseases, such as asthma and chronic obstructive pulmonary disease [36]; E-caryophyllene is an antiinflammatory molecule because (a) it produces an anti-spasmodic activity on smooth muscle, which is probably related to Ca 2+ channel blockade [37]; and (b) it induces inhibition of cytokines involved in the arachidonic acid and histamine pathways [38].…”

Section: Resultsmentioning

confidence: 99%

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On the Possible Chemical Justification of the Ethnobotanical Use of Hyptis obtusiflora in Amazonian Ecuador

Luzuriaga-Quichimbo

Salas

Cerón-Martínez

et al. 2018

Plants

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In rural areas of Latin America, Hyptis infusions are very popular. Hyptis obtusiflora extends from Mexico throughout Central America to Bolivia and Peru. It has added value in Ecuador where it has been used by different ethnic groups. We aimed to learn about the traditional knowledge of ancient Kichwa cultures about this plant, and to contrast this knowledge with the published information organized in occidental databases. We proposed to use traditional knowledge as a source of innovation for social development. Our specific objectives were to catalogue the uses of H. obtusiflora in the community, to prospect on the bibliography on a possible chemical justification for its medicinal use, to propose new products for development, and to give arguments for biodiversity conservation. An ethnobotanical survey was made and a Prisma 2009 Flow Diagram was then followed for scientific validation. We rescued data that are novel contributions for the ethnobotany at the national level. The catalogued main activity of anti-inflammation can be related to the terpene composition and the inhibition of xanthine oxidase. This opens the possibility of researching the extract of this plant as an alternative to allopurinol or uricosuric drugs. This is a concrete example of an argument for biodiversity conservation.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

On the Possible Chemical Justification of the Ethnobotanical Use of Hyptis obtusiflora in Amazonian Ecuador

Luzuriaga-Quichimbo

Salas

Cerón-Martínez

et al. 2018

Plants

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“…In fact, the antibacterial effects of germacrene D quantified at 19.7% and β ‐caryophyllene (15.5%) were previously described (Deba et al, ; Belmekki, Bendimerad, Bekhechi, & Fernandez, ). The antarthritic, anti‐inflammatory, antiviral, antimutagenic, local anesthetic and anticarcinogenic activities of β ‐caryophyllene have been also described (Oliveira‐tintino et al, ). However, we should not neglect the fact that the essential oil is a phytocomplex extract, thus the interaction between minor and major constituents is also important, and that every single compound acts synergistically with the others.…”

Section: Discussionmentioning

confidence: 97%

Chromatographic analysis, antimicrobial and insecticidal activities of the essential oil of Phlomis floccosa D. Don.

Mokni

Majdoub

Chaieb

et al. 2019

Biomedical Chromatography

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The present study was conducted to investigate for the first time the chemical composition and insecticidal and antimicrobial properties of Phlomis floccosa D. Don. essential oil isolated by hydro-distillation of its aerial parts. Qualitative and quantitative analyses of the essential oil on the basis of gas chromatography and mass spectrometry (GC/FID and GC/MS) revealed the presence of 59 organic volatiles representing 86.9% of the total constituents. The major compounds were germacrene-D (19.7%) followed by β-caryophyllene (15.5%), caryophyllene oxide (8.3%), hexadecenoic acid (7.9%) and carvacrol (6.1%). The broth microdilution method was conducted to test the antimicrobial activity of the essential oil against five pathogens: Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Staphylococcus aureus, Bacillus subtilis and the yeast Candida albicans. The oil of P. floccosa D. Don. shows promising activity against the Gram-positive bacteria S. aureus and B. subtilis and the yeast C. albicans (minimum inhibitory concentration = 625 μg.mL −1 ).The effectiveness of the essential oil was assessed on both Tribolium confusum and Sitophilus zeamais pest insects and it was more pronounced against T. confusum, showing a moderate mortality of 47.5%.

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“…β-Caryophyllene is a bicyclic sesquiterpene found in several EOs, such as Aquilaria crassna [129], Croton campestres [130], Psidium guineense [131] and Zanthoxylum acanthopodium [132]. β-Caryophyllene is the main component of Cannabis essential oil and is capable of binding to CB2 receptors.…”

Section: βEta-caryophyllenementioning

confidence: 99%

“…However, the compound can be classified as non-psychoactive cannabinoid [133]. Certain pharmacological properties have already been attributed to β-caryophyllene such as anticancer, anti-oxidant, and antimicrobial [129], as well as antidepressant [134] and anti-inflammatory [130]. In a pre-clinical study in female Swiss mice, no toxicological effects were observed up to a dose of 2000 mg/kg (p.o.)…”

Section: βEta-caryophyllenementioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound β-caryophyllene in in vivo models

Cited by 54 publications

References 109 publications

On the Possible Chemical Justification of the Ethnobotanical Use of Hyptis obtusiflora in Amazonian Ecuador

On the Possible Chemical Justification of the Ethnobotanical Use of Hyptis obtusiflora in Amazonian Ecuador

Chromatographic analysis, antimicrobial and insecticidal activities of the essential oil of Phlomis floccosa D. Don.

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

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