Anti-inflammatory and antibacterial evaluation of Thymus sipyleus Boiss. subsp. sipyleus var. sipyleus essential oil against rhinosinusitis pathogens

Demirci, Fatih; Karaca, Nursenem; Tekin, Mehmet; Demırcı, Betül

doi:10.1016/j.micpath.2018.06.025

Cited by 22 publications

(18 citation statements)

References 19 publications

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“…The inhibition efficiency of FT oil was about two-thirds of NGDA (stronger inhibitor of LOX enzymes), showing its potential value in anti-inflammatory applications. For comparison, the oil from Psidiumguajava fruits showed an IC 50 of about 196 μg/mL on LOX-5 [27], and the essential oil from thyme species only showed 12% efficiency at 100 μg/mL [28].…”

Section: Resultsmentioning

confidence: 99%

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Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

et al. 2019

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Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of Torreya fargesii (T. fargesii) by fractionation. Fractionated kernel oil of T. fargesii (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 μg/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 μg/mL) more effectively than the non-fractionated oil. This shows that increasing the amount of sciadonic acid can enhance the anti-inflammatory effect of the kernel oil. This research also indicates that fractionation is a feasible way to obtain sciadonic acid–rich functional oil with potential pharmacological effects.

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Section: Resultsmentioning

confidence: 99%

“…Here, the subscripts s and bl indicate sample and reagent blank, respectively. Nordihydroguaiatic acid (NGDA, IE% = 100%, IC 50 = 2.95 ± 0.21 μg/mL) [28] was used as a positive control to calculate the IE% of oil samples. The formation of hydroperoxide conjugated dienes gave strong absorption at 234 nm (ε > 25,000 M −1 .cm −1 ).…”

Section: Methodsmentioning

confidence: 99%

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

et al. 2019

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“…Identification of these compounds was carried out by comparing their linear retention indexes (LRI) to a series of C 9 -C 20 n-alkane standard solutions (Fluka, Buchs, Switzerland). Computer matching was carried out using commercial (Wiley GC/MS Library, MassFinder Software 4.0), and the in-house 'Başer Library of Essential Oil Constituents' library as well as the literature was performed (Demirci et al, 2018).…”

Section: Chromatographic Analysesmentioning

confidence: 99%

Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. orientale (Boiss.) Tutin essential oils

et al. 2021

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The chemical compositions of the essential oils (EOs) obtained by hydrodistillation from different parts of Cnidium silaifolium ssp. orientale (Boiss.) Tutin were analyzed both by GC-FID and GC/MS, simultaneously. One hundred nine compounds representing 90.1% of the total volatiles in the EOs were identified with the main characteristic compounds α-pinene (50.3%) in the root, germacrene D (20.3%) in the fruit, and β-caryophyllene (18.7%) in the aerial parts of C. silaifolium ssp. orientale. The antimicrobial activity against human pathogenic Gram-negative and Gram-positive bacteria was evaluated by the in vitro microdilution method. Antibacterial succeptibility was observed from the root and aerial part EOs against Staphylococcus aureus (0.039 and 0.156 mg/mL, respectively); while the fruit EO was most effective against Bacillus cereus at 0.07 mg/mL. The antioxidant capacities of the EOs were also evaluated by in vitro DPPH• and ABTS•+ scavenging assays, where no significant activity was observed compared to ascorbic acid and Trolox.

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“…Thymus sipyleus Boiss. is endemic in Turkey, and known with local Turkish names as "kekik, limon kokulu kekik, keklik otu, yayla kekiği, nemamul otu, sater" [11].…”

Section: Introductionmentioning

confidence: 99%

“…2%), camphene (3.6%), myrcene (3.4%).Fifty-four volatiles of the KT192 sample were identified representing 97.8% of the oil and the major compounds are carvacrol (18.2%) and 1,8 cineole (11.6%). The contents of fifteen volatiles are higher than 1% and other major compounds are p-cymene (9.2%), camphor (8.3%), camphene (7.2%), 3-octanol (5.8%), β-caryophyllene (5.0%), borneol (4.9%) Demirci et al (2018). reported that the essential oil of air dried and crushed aerial parts of T. sipyleus subsp.…”

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confidence: 99%

Volatile constituents of three Thymus sipyleus Boiss. subspecies from different sites in Turkey

2021

Turk J Chem

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This study was designed to reveal the chemical diversity of some Thymus sipyleus subspecies growing wild in Turkey and to compare the volatile compound profiles by using micro(hydro)distillation technique. For this purpose, volatile compounds isolated by microdistillation from nine samples (three plant samples collected from different regions in Antalya) of Thymus sipyleus Boiss. subsp. sipyleus var. sipyleus, T. sipyleus Boiss. subsp. sipyleus var. davisianus Ronniger, and T. sipyleus Boiss. subsp. rosulans (Borbas) Jalas were analyzed by GC and GC-MS systems. 1,8-Cineole, p-cymene, α-terpineol and carvacrol were identified as major compounds in T. sipyleus subsp. sipyleus var. sipyleus samples. Geranial, neral, 1,8cineole and β-caryophyllene, and α-terpineol and geranial were the main compounds in T. sipyleus subsp. sipyleus var. davisianus samples. β-Caryophyllene, intermedeol, 1,8cineole and α-terpineol, α-pinene were the major compounds in T. sipyleus subsp. rosulans samples. As known, thymol is the main compound in most Thymus species in Turkey, but, according to our study, chemical polymorphism has have been found among the T. sipyleus subspecies.

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Anti-inflammatory and antibacterial evaluation of Thymus sipyleus Boiss. subsp. sipyleus var. sipyleus essential oil against rhinosinusitis pathogens

Cited by 22 publications

References 19 publications

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Chemical compositon, antibacterial and antioxidant activities of Cnidium silaifolium ssp. orientale (Boiss.) Tutin essential oils

Volatile constituents of three Thymus sipyleus Boiss. subspecies from different sites in Turkey

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