Anti-inflammatory and antinociceptive effects of Arrabidaea brachypoda (DC.) Bureau roots

Rocha, Cláudia Quintino da; Vilela, Fabiana C.; Cavalcante, Gustavo P.; Santa-Cecília, Flávia V.; Santos-e-Silva, Lucas dos; Santos, Marcelo H. dos; Giusti‐Paiva, Alexandre

doi:10.1016/j.jep.2010.10.009

Cited by 48 publications

(41 citation statements)

References 22 publications

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“…serotonin, histamine, bradykinin and prostaglandins), which subsequently cause sensitization of the central neurons leading to changes in central pain processing. [4445] It is known that centrally-acting drugs, such as opioids, inhibit both phases equally,[46] however, many NSAIDs and corticosteroids inhibit only the late phase. Both XAE and XA inhibited the neurogenic and inflammatory phases of the mouse formalin test.…”

Section: Discussionmentioning

confidence: 99%

Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

et al. 2012

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Background:Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including rheumatism, headache, colic pain, and neuralgia. Little pharmacological data exists in scientific literature of the effect of the fruit extract and its major diterpene, xylopic acid, on pain. The present study evaluated the analgesic properties of the ethanol extract of X. aethiopica (XAE) and xylopic acid (XA), in murine models.Materials and Methods:XAE and XA were assessed in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (Tail-flick and Hargreaves thermal hyperalgesia tests), and mechanical (Randall-Selitto paw pressure test) pain models.Results:XAE and XA exhibited significant analgesic activity in all the pain models used. XAE (30-300 mg kg-1, p.o.) and XA (10-100 mg kg-1, p.o.) inhibited acetic acid-induced visceral nociception, formalin- induced paw pain (both neurogenic and inflammatory), thermal pain as well as carrageenan-induced mechanical and thermal hyperalgesia in animals. Morphine (1-10 mg kg-1, i.p.) and diclofenac (1-10 mg kg-1, i.p.), used as controls, exhibited similar anti-nociceptive activities. XAE and XA did not induce tolerance to their respective anti-nociceptive effects in the formalin test after chronic administration. Morphine tolerance did not also cross-generalize to the analgesic effects of XAE or XA.Conclusions:These findings establish the analgesic properties of the ethanol fruit extract of X. aethiopica and its major diterpene, xylopic acid.

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Section: Discussionmentioning

confidence: 99%

Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

et al. 2012

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“…The Brazilian cerrado (neotropical savannah) is one of the major biogeographic regions (biomes) of the world, with more than 7000 native species of vascular plants. Many of these plants are commonly used as natural remedies by people living in the cerrado area (Rocha et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test

Resende

Campos

Silva

et al. 2015

Regulatory Toxicology and Pharmacology

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“…There is evidence that proton-sensing GPCR are involved with the modulation of inflammatory pain acting on TRPV1 and also the ASIC family [25][26][27]. Since DEAB showed no effect over TRPV1 and exhibited a diminished response in the acidified saline model, combined with its anti-inflammatory effect already observed by Da Rocha et al [5], we cannot rule out the hypothesis of the direct or indirect action of the extract though the inhibition of GPCRs. TRPM8 is a major cold and cooling transduction channel in mammalian sensory neurons and it is strongly activated by the cool-mimetic chemical menthol and by physical cooling [20].…”

Section: Resultsmentioning

confidence: 71%

Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of <em>Arrabidaea Brachypoda </em>(DC) Bureau

Rodrigues¹,

Rocha²,

Périco³

et al. 2017

Preprint

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Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it is popularly used as a natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition and antinociceptive activity of the dichloromethane fraction from the roots of A. brachypoda (DEAB) and its mechanism of action. The chemical composition was characterized by high-performance liquid chromatography, and this fraction is composed only of dimeric flavonoids. The antinociceptive effect was evaluated in formalin and hot plate tests after oral administration (10-100 mg/kg) in male Swiss mice. We also investigated the involvement of TRPV1 (transient receptor potential vanilloid 1), TRPA1 (transient receptor potential ankyrin 1), TRPM8 (transient receptor potential melastatin 8), and ASIC (acid-sensing ion channel), as well as the opioidergic, glutamatergic, and supraspinal pathways. Moreover, the nociceptive response was reduced (30 mg/kg) in the early and late phase of the formalin test. DEAB activity appears to involve the opioid system, TRPM8, and ASIC receptors, clearly showing that the DEAB alleviates acute pain in mice and suggesting the involvement of the TRPM8 and ASIC receptors and the opioid system in acute pain relief.

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Anti-inflammatory and antinociceptive effects of Arrabidaea brachypoda (DC.) Bureau roots

Abstract: Arrabidaea brachypoda ethanol extract markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports the previous claims of traditional use.

Cited by 48 publications

References 22 publications

Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models

Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test

Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of <em>Arrabidaea Brachypoda </em>(DC) Bureau

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