Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: Experimental animal study

Bashkaran, Karuppannan; Zunaina, Embong; Shaharuddin, Bakiah; Sulaiman, Siti Amrah; Sirajudeen, Kns; Naik, Venkatesh R

doi:10.1186/1472-6882-11-90

Cited by 70 publications

(56 citation statements)

References 25 publications

(34 reference statements)

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“…Different antioxidants present in honey include flavonoids, monophenolics, polyphenolics and vitamin C (31-33). Free radicals derived from oxygen also known as Reactive Oxygen Species (ROS), are produced by the respiratory mitochondrial chain and leukocytes in the process of inflammation (34). Vitamin C reduces peroxides (one of the ROS) and acts as an important antioxidant (35).…”

Section: Resultsmentioning

confidence: 99%

Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review

Yaghoobi

Kazerouni

2013

Jundishapur J Nat Pharm Prod

206

150

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Context:To provide an updated review of published literature on the anti-oxidant, anti-bacterial and anti-inflammatory properties of honey. Evidence Acquisition: CINAHL, BioMed Central, Cochrane Library, Medline and Embase data bases and reference lists were used to find randomized controlled trials and review articles. Randomized controlled trials using honey with a comparator were reviewed, along with published review articles to determine the relative benefits of tropical honey. These methods were undertaken by three reviewers. Results: Honey has anti-oxidant, anti-bacterial and anti-inflammatory properties. It can be used as a wound dressing to promote rapid and improved healing. These effects are due to honey's anti-bacterial action, secondary to its high acidity, osmotic effect, anti-oxidant content and hydrogen peroxide content. The use of honey leads to improved wound healing in acute cases, pain relief in burn patients and decreased inflammatory response in such patients. However, it has proven to be ineffective in chronic leg ulcers. Overall, studies have been done in favor of the use of honey in medicine. Conclusions: Honey has almost equal or slightly superior effects when compared with conventional treatments for acute wounds and superficial partial thickness burns. More randomized controlled trials with significant statistical power comparing different kinds of honey, are required in order to create a strong body of evidence towards definite recommendations for medical use. There is biological plausibility.Keywords: Honey; Biological Dressings; Burns; Anti-inflammatory Agents Implication for health policy/practice/research/medical education: Honey has almost equal or slightly superior effects when compared with conventional treatments for acute wounds and superficial partial thickness burns. More randomized controlled trials with significant statistical power comparing different kinds of honey, are required in order to create strong body of evidence towards definite recommendations for medical use. There is biological plausibility. Application of this topical in comparison to other current medical interventions in this field may attract attentions of third party payers, policy makers and the health system in terms of their budget and the cost effectiveness of this type of therapy.

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Section: Resultsmentioning

confidence: 99%

Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review

Yaghoobi

Kazerouni

2013

Jundishapur J Nat Pharm Prod

206

150

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“…Phenolic compounds are clinically important inhibitors of inflammatory mediator's production in vivo [23].…”

Section: Discussionmentioning

confidence: 99%

Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

2015

J Coast Life Med

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“…Alkali injury of the cornea is one of the most dangerous injuries to the eye [12] . The cornea has a real requirement for vitamin A (retinol) .Vitamin A is necessary for the normal growth and differentiation of epithelium, and its deficiency leads to increased epidermal keratinization and squamous metaplasia [13] .…”

Section: Discussionmentioning

confidence: 99%

Role of vitamin A in the healing process of alkali caused corneal injury of adult male albino rat: Histological and immunohistochemical study

Abdelwahab

El-Hameed

Saber

et al. 2017

Journal of Medical Histology

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Background and Aim: Alkali burn of the cornea is considered as the most dangerous injury to the eye. It causes corneal infection, ulceration, perforation, neovascularization (NV) and opacification. Vitamin A is necessary for the normal growth and differentiation of epithelium; it is expected to promote the mechanical repair of corneal epithelial defects The present study is planned to investigate the effect of vitamin A eyegel on wound healing of the corneal alkali burn in rats. Materials and Methods: A total of thirty male albino rats were used. Rats were divided randomly into four groups: Group I, the control group; included three rats, received distilled water. Each of group II, III, IV included 9 rats: their central corneas of the right eyes were injured by contacting them with filter paper saturated with 0.01 m NaOH for 45 seconds. Group II, the non-treated group, injured and received distilled water. Group III, the antibiotic treated group, received antibiotic eye drops (lincomycin hydrochloride eye drops) 3 times per day for 3 days. Group IV, vitamin A treated group, received the same course of antibiotic and vitamin A eye gel (Hypotear gel 1000 IU/g) three times per day. for 3 days. The eyeball was taken out, rapidly fixed and processed for light microscopic, immunohistochemical and morphometric studies. Specimens were taken after 24, 48 and 72 hr. post-injury for tissue preparation and study of structural changes and immuno-histochemical analysis using Ki67 (detection of cellular proliferation) and transforming growth factor -beta (TGF-β) which is one of the most critical growth factors in establishing the pathologic lesion after corneal alkali burn. Results: Hematoxylin and eosin stained sections showed rapid healing of corneal ulcer in vitamin A treated group, with absence of neo-vasculariztion and inflammatory cellular infiltration. Immunohistochemical results showed that the use of vitamin A enhance cell proliferation (detected with Ki67) and decrease the expression of TGF-β which is one of the most critical growth factors in establishing the pathological lesion after corneal alkali burn. Conclusions: Vitamin A eye gel helped rapid healing of corneal alkali burn. This effect may be due to its anti-inflammatory effect and stimulation of cell proliferation.

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Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: Experimental animal study

Cited by 70 publications

References 25 publications

Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review

Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review

Preliminary comparative study of anti-inflammatory effect of unheated and heat-treated Sahara honey: In vivo approach

Role of vitamin A in the healing process of alkali caused corneal injury of adult male albino rat: Histological and immunohistochemical study

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