Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné

Cheng, Wenming; Li, Jun; You, Tianyan; Hu, Chengmu

doi:10.1016/j.jep.2005.04.035

Cited by 164 publications

(104 citation statements)

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“…Dimethylbenzene-induced inflammation in mice is a preliminary and simple model for searching for potential antiinflammatory drugs (Cheng et al, 2005). In our study, the results demonstrate the topical anti-inflammatory properties of XYT and they may justify the use of this medicine formula for the treatment of inflammatory diseases in Chinese.…”

Section: Discussionsupporting

confidence: 57%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

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Section: Discussionsupporting

confidence: 57%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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“…iNOS is an another key enzyme which is involved in the synthesis of nitric oxide from the amino acid l-arginine. The inhibition of COX-2 and iNOS expression has been shown to suppress the development of skin tumor [32]. Previous report stated that sulindac, a specific inhibitors for COX-1/COX-2 expression that may reduce prostaglandin production leads to the inhibition of UVB-induced skin cancer [33].…”

Section: Discussionmentioning

confidence: 99%

Morin Prevents Ultraviolet-B Radiation-Induced Photocarcinogenesis Through Activating Thrombospondin-1 in the Mouse Skin

Anjugam

Sridevi

Prasad

et al. 2018

Asian J Pharm Clin Res

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Objective: In this study, we investigated whether morin, a natural flavonoid, could able to inhibit ultraviolet B (UVB)-induced carcinogenesis in the skin of Swiss albino mice. Methods:The mice were exposed to UVB radiation (180 mJ/cm 2 ) on weekly thrice for 30 weeks, and morin was administered intraperitoneal and topical application 1 h before UVB exposure. UVB radiation induces the overexpression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and Bcl-2 genes. Results:Morin significantly prevented UVB-induced activation of COX-2, iNOS, VEGF, TGF-β, and Bcl-2 expression in mouse skin. Thrombospondin-1 (TSP), a novel endogenous factor, inhibits angiogenesis and inflammation. Conclusion:The present study illustrates that the protective effect of morin against UVB-induced carcinogenesis may be modulated through activation of TSP-1 in UVB-exposed Swiss albino mice.

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“…In order to investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. Recent studies reported that CHI extract significantly inhibited the expression of pro-inflammatory cytokines but most of the previous studies were used a specific part of CHI such as roots, stem, leaf and flower, which was extracted using an ethanol [18,19,21]. There was no study using whole plant extracts of chrysanthemum with water.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant

Kang¹

2015

Journal of Korean Biological Nursing Science

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Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and100 μg/mL). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1β, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-1β, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of PGE2 expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Key Words: Anti-inflammation; Chrysanthemum indicum; RAW 264.7 cell

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Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné

Cited by 164 publications

References 1 publication

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Morin Prevents Ultraviolet-B Radiation-Induced Photocarcinogenesis Through Activating Thrombospondin-1 in the Mouse Skin

Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant

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