Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity

Li, Tan; Chen, Hong; Wei, Na; Mei, Xin; Shi, Zhijun; Liu, Dailin; Gao, Ying; Bai, Shuang; Liu, Xiaoguang; Zhou, Ya-Xun

doi:10.1016/j.intimp.2011.11.004

Cited by 70 publications

(34 citation statements)

References 38 publications

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“…Effects on other cellular pathways have also been reported including NOXA [5], mitogen-activated protein kinase (MAPK) [ [18,23,69], epidermal growth factor (EGF) [70], and tumor necrosis factor α (TNFα) [56]. These molecular effects could explain the apoptotic, antiangiogenic [15,16,54,[58][59][60][61][62][63][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86]; anti-inflammatory [55, 56, 68, [87][88][89][90]; anti-metastasis [61, [91][92][93][94][95], and cell cycle inhibition effects of artemisinin compounds. Of course, most of these changes in cellular molecular activities could result from an increase in free radical activity in cancer cells due to the reaction of artemisinins with iron.…”

Section: Artemisinin Monomersmentioning

confidence: 99%

Development of artemisinin compounds for cancer treatment

2012

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Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free radicals. Cancer cells contain significantly more intracellular free iron than normal cells and it has been shown that artemisinin and its analogs selectively cause apoptosis in many cancer cell lines. In addition, artemisinin compounds have been shown to have anti-angiogenic, anti-inflammatory, anti-metastasis, and growth inhibition effects. These properties make artemisinin compounds attractive cancer chemotherapeutic drug candidates. However, simple artemisinin analogs are less potent than traditional cancer chemotherapeutic agents and have short plasma half-lives, and would require high dosage and frequent administration to be effective for cancer treatment. More potent and target-selective artemisinin-compounds are being developed. These include artemisinin dimers and trimers, artemisinin hybrid compounds, and tagging of artemisinin compounds to molecules that are involved in the intracellular iron-delivery mechanism. These compounds are promising potent anticancer compounds that produce significantly less side effect than traditional chemotherapeutic agents.

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Section: Artemisinin Monomersmentioning

confidence: 99%

Development of artemisinin compounds for cancer treatment

2012

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“…In human rheumatoid arthritis fibroblast-like synoviocytes, ART exerts an antiinflammatory effect via inhibition of NF-κB and PI3K/Akt signal pathway [27]. Besides, ART could suppress serum levels of cytokines and abrogate damage in mice with lupus nephritis via interfering nuclear translocation of NF-κB p65 subunit [28].…”

Section: Discussionmentioning

confidence: 99%

Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation

Chen

Shuai

et al. 2015

J Endocrinol Invest

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“…These results are especially of high importance if one were to consider potential therapeutic uses for SLAK as an immunomodulant used in treatments for inflammatory diseases. A few studies have shown some sesquiterpene lactones from other Artemisia species have immunomodulatory effect on lymphocytes (Chang et al, 2009;Li et al, 2012;Wang et al, 2005;Yin et al, 2010Yin et al, , 2011. In this regard, SLAK behaved in a manner similar to cirsilineol, jaceosidin, and artemisinin isolated from these plants, i.e., each suppressed splenocyte proliferation and led to skewed T H 2-type cytokine formation (Li et al, 2012;Yin et al, 2010Yin et al, , 2011.…”

Section: Discussionmentioning

confidence: 99%

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

Rabe¹,

Iranshahi

Rastin³

et al. 2014

Journal of Immunotoxicology

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Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate immunomodulatory/anti-inflammatory properties of this plant and elucidate potential underlying mechanisms for the actions. Effects of the SLAK on mitogeninduced murine splenocyte proliferation and interleukin (IL)-4 and interferon (IFN)-secretion were evaluated. To assess anti-inflammatory activities, levels of inducible of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ), as well as expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in peritoneal macrophages was examined. The results showed that SLAK noticeably was capable of suppressing PHA/LPS-stimulated splenocyte proliferation and of up-regulating production of the T-helper (T H )-2 cell cytokine IL-4 while down-regulating formation of T H 1 IFN. In addition, while SLAK caused negligible proliferation inhibition, peritoneal macrophages displayed considerable decrease in NO and PGE 2 production along with iNOS and COX-2 expression. The current experiment shows Artemisia khorasanica -a traditionally used herb -may have immunomodulatory and anti-inflammatory effects. It is anticipated that the ingredients may be employed as therapeutic candidates in the regulation of some immune responses implicated in various conditions and ailments.

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Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity

Cited by 70 publications

References 38 publications

Development of artemisinin compounds for cancer treatment

Development of artemisinin compounds for cancer treatment

Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation

In vitroimmunomodulatory properties of a sesquiterpene lactone-bearing fraction fromArtemisia khorassanica

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