Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica

Yang, Wanqing; Song, Yuelin; Zhu, Zhixiang; Su, Cong; Zhang, Xu; Wang, Juan; Shi, She‐Po; Tu, Pengfei

doi:10.1016/j.fitote.2015.07.006

Cited by 51 publications

(22 citation statements)

References 37 publications

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“…Furthermore, pharmacological studies have shown that it has antimicrobial (11), hepatoprotective (12), antioxidative (13) and cholinesterase inhibitory activities (14), and activates dendritic cells (15) and the actions of lipolytic hormones (16). Furthermore, it inhibits the production of prostaglandin E 2 (17) and nitric oxide (NO) (18,19), and reduces the release of histamine (20). In addition, the ethanolic extract of A. dahurica displayed anti-inflammatory effects by the upregulation of heme oxygenase-1, particularly in mice with asthma (21,22).…”

Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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Abstract. Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β-sitosterol (14) and daucosterol (15). Compounds 1-13 were able to reduce the release of histamine, with compounds 4-6 exhibiting the most potent activity. Furthermore, compounds 1-12 were able to inhibit the secretion of tumor necrosis factor-α, interleukin (IL)-1β and IL-4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor-κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H 1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.

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Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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“…In AE, the active compound, furanocoumarins, possessed anti-inflammatory effect in the LPS-stimulated RAW264.7 macrophage cells [ 29 ]. Imperatorin, another active compound in AE, showed antioxidant effect protected renal injury by reducing NADPH oxidase and inhibiting of MAPK pathway [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats

Yang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The main objective of wound treatments is to restore the functional skin properties and prevent infection. Traditional Chinese medicine provides alternative anti-inflammatory, antimicrobial, and wound healing therapies. Both Angelica dahurica extract (AE) and Rheum officinale extract (RE) possess antimicrobial activity. In this study, AE and RE were applied in wound treatment to investigate their healing effects. Thirty Sprague-Dawley rats with dorsal full-thickness skin excision were divided into normal saline (NS), AE, RE, AE plus RE (ARE), and Biomycin (BM) groups. The treatment and area measurement of wounds were applied daily for 21 days. Wound biopsies and blood samples were obtained for histology examinations and cytokine analysis. Results showed that wound contraction in ARE group was significantly higher than that in NS and BM groups (P < 0.05). Histological analysis showed that more inflammatory cell infiltration, collagen fibers, and myofibroblasts were observed in ARE treated group than those in NS group on days 3–5. In ARE group, plasma IL-6 levels were elevated during days 3–5 (P > 0.05), and plasma TGF-β1 levels were significantly lower than those in the NS group on days 3-4 (P < 0.05). In conclusion, ARE accelerates wound healing during inflammation and proliferation phases.

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“…This herb is commonly used to treat pain, abscesses, furunculosis, and acne [ 17 ]. It is also reported to possess anti-inflammatory, antitumor, antioxidant, and skin whitening properties [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. However, the authentication of the Angelica species for medical purposes is greatly challenging, due to their extremely polymorphic traits and controversial taxonomic history [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Authentication of the Herbal Medicine Angelicae Dahuricae Radix Using an ITS Sequence-Based Multiplex SCAR Assay

et al. 2018

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The accurate identification of plant species is of great concern for the quality control of herbal medicines. The Korean Pharmacopoeia and the Pharmacopoeia of the People’s Republic of China define Angelicae Dahuricae Radix (Baek-Ji in Korean and Bai-zhi in Chinese) as the dried roots of Angelica dahurica or A. dahurica var. formosana belonging to the family Apiaceae. Discrimination among Angelica species on the basis of morphological characteristics is difficult due to their extremely polymorphic traits and controversial taxonomic history. Furthermore, dried roots processed for medicinal applications are indistinguishable using conventional methods. DNA barcoding is a useful and reliable method for the identification of species. In this study, we sequenced the internal transcribed spacer (ITS) region of nuclear ribosomal RNA genes in A. dahurica, A. dahurica var. formosana, and the related species A. anomala and A. japonica. Using these sequences, we designed species-specific primers, and developed and optimized a multiplex sequence-characterized amplified region (SCAR) assay that can simply and rapidly identify respective species, and verify the contamination of adulterant depending on the polymerase chain reaction (PCR) amplification without sequencing analysis in a single PCR reaction. This assay successfully identified commercial samples of Angelicae Dahuricae Radix collected from Korean and Chinese herbal markets, and distinguished them from adulterants. This multiplex SCAR assay shows a great potential in reducing the time and cost involved in the identification of genuine Angelicae Dahuricae Radix and adulterant contamination.

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Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica

Cited by 51 publications

References 37 publications

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Effects of Angelica dahurica and Rheum officinale Extracts on Excisional Wound Healing in Rats

Authentication of the Herbal Medicine Angelicae Dahuricae Radix Using an ITS Sequence-Based Multiplex SCAR Assay

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