Anti-inflammatory Effect of Antioxidant Pequi (Caryocar Brasiliense) Oil Capsules and Antioxidant Effect of Vitamin D and Physical Activity on Systemic Lupus Erythematosus Patients

Abstract

Objectives: Verifying in SLE patients whether antioxidant supplementation with pequi oil capsules could reduce oxidative DNA damage and inflammation in SLE patients. Patients and Methods:A controlled randomized, crossover, double-blind study was conducted with 38 SLE patients aged 18 to 60, with SLE Disease Activity Index (SLEDAI) below 10, chosen from 73 lupus patients consecutively seen in the University Hospital of Brasília (HUB) Rheumatology Clinic. They were randomized into two groups: one group of 22 patients received one placebo capsule per day for 60 consecutive days, and the other 16 patients received one 400 mg pequi oil in capsule per day over the same period. There was a 60-day wash-out, and then the patients switched groups: those who had received pequi oil received placebo and vice versa, also for 60 consecutive days. We collected blood, urine, anthropometric and social data from patients before and after each period, totaling four collections.Results: Twenty-nine women finished this clinical trial. The mean age was 33.66 years, the mean BMI was 24.1 kg/m 2 and the mean disease duration was 7.8 years. The irreversible damage index of the disease and the SLEDAI had no influence on DNA damage index (DDI). A correlation was found between DDI and HDL (r = −0.414, p = 0.029). A significant difference was detected in the average rate of DDI between physical activity practitioners and non-practitioners (p = 0.045) and between users and non-users of vitamin D (p = 0.006). Moreover, high-sensitivity C-reactive protein (hs-CRP) fell significantly after treatment with pequi oil (p = 0.0161).Conclusions: Although pequi oil did not significantly reduce the DNA damage index, it effectively reduced hs-CRP levels in these patients, indicating reduced inflammation with the use of antioxidant supplementation. Furthermore, the practice of physical activity and the use of vitamin D in patients with SLE could have an independent antioxidant effect.

Efeito do óleo de pequi (Caryocar brasiliense) sobre a composição corporal e a pressão arterial de adultos fisicamente ativos: um estudo quasi-experimental

“…Furthermore, there was a tendency for blood pressure reduction, suggesting a possible hypotensive effect of the supplementation. In addition, previous investigations using the same dosage of the present study showed that pequi supplementation for 14 days may also attenuate DNA damage in runners , as well as diminish inflammation measured by high sensitive C-reactive protein in a sample of chronic inflammatory disease patients after 60 days of intervention (MONTALVÃO et al, 2016). In an animal model, a previous study showed that pequi oil supplementation for 5 weeks promoted a protective effect on the hepatic tissue by reducing lipid peroxidation after swimming exercise (VALE et al, 2019).…”

Supplementation with an Antioxidant Rich Oil Does Not Influence Blood Lactate, Rate of Perceived Exertion and Muscle Soreness after Resistance Exercise

“…Of note, findings of previous research showed that supplementation with pequi oil (i.e. 400mg/day) can attenuate cardiovascular inflammation in Systemic lupus erythematosus patients [2]. Moreover, it has been shown that pequi oil supplementation (i.e.…”

Antioxidant effect of the pequi oil (Caryocar brasiliense) on the hepatic tissue of rats trained by exhaustive swimming exercises

“…Studies have shown that the ethanol extract of this fruit has high total phenolic content and an excellent antioxidant activity via bioactive molecules (Miranda-Vilela et al, 2009a). Montalvão et al (2016) studying the antioxidant effect of pequi oil in patients with systemic lupus erythematosus have shown a significant reduction of the inflammatory processes. However, no consistent data were found about the possible protective role of the antioxidants contained in pequi oil during strenuous exercise, in terms of maintaining the morphological integrity of liver cells, justifying our study.…”