Anti-inflammatory effects of essential oil isolated from the buds of Cleistocalyx operculatus (Roxb.) Merr and Perry

Dung, Nguyễn Thị; Bajpai, Vivek K.; Yoon, Jung In; Kang, Sun Chul

doi:10.1016/j.fct.2008.11.033

Cited by 51 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-1β is produced by monocytes, macrophages, endothelial cells and fibroblasts (Dung et al, 2009). Okamoto et al (1998) and Curra et al (2013) indicated that 5-FU is a potent inducer of several types of cytokines, including IL-1β.…”

Section: Controlmentioning

confidence: 99%

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Mohamed¹,

Safwat²

2016

Beni-Suef University Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

Available onlineA B S T R A C T 5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors.Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardiotoxicity and oxidative stress in albino rats. The rats were divided into three groups. Rats in the control group received saline daily for 8 days only.Rats in FU-treated group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rats in LS-treated group were orally dosed with LS (550 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of cTnI, CK-MB, lipid profile and a moderate elevation of cardiac MDA. 5-FU significantly decreased serum HDL-c and GSH concentration in cardiac homogenate. Its administration also resulted in the release of some inflammatory markers such as myeloperoxidase and Interleukin-1β (IL-1β). All 5-FU altered parameters were markedly ameliorated by LS pre-co-post-treatment. Results of the present study suggest that LS has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the antioxidant and anti-inflammatory activities.

show abstract

Section: Controlmentioning

confidence: 99%

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Mohamed¹,

Safwat²

2016

Beni-Suef University Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Recently, the antiinflammatory activities of the essential oil of the C. operculatus buds were investigated in in vitro and in vivo. These results suggested that its essential oil might exert an anti-inflammatory effect by suppressing the expression of pro-inflammatory cytokines, and this suppression is partially mediated by blocking NF-κB activation (Dung et al, 2009). Previous phytochemical attention has led to the characterization of oleanane-type triterpenes (Zhang et al, 1990;Nomura et al, 1993), and flavonoids (Ye et al, 2004).…”

Section: Introductionmentioning

confidence: 96%

Cholinesterase inhibitors from Cleistocalyx operculatus buds

et al. 2010

View full text Add to dashboard Cite

Five flavonoids, myricetin-3'-methylether 3-O-β-D: -galactopyranoside (1), myricetin-3',5'-dimethylether 3-O-β-D: -galactopyranoside (2), quercetin (3), kaempferol (4), and tamarixetin (5) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses, including 2D NMR. Their anti-Alzheimer effects were evaluated via acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. All five compounds 1-5 showed potential inhibitory activities against AChE with IC(50) values of 19.9, 37.8, 25.9, 30.4 and 22.3 μM, respectively, while compounds 1, 3, 4 and 5 also possessed BChE inhibitory activity with IC(50) values of 152.5, 177.8, 62.5, and 160.6 μM, respectively.

show abstract

“…Inflammation is a normal physiological and immune response to tissue injury and occurs when the human body attempts to counteract potentially injurious agents, such as invading bacteria, viruses, and other pathogens [17]. Macrophages play an important role in triggering inflammation during pathological conditions by overproducing inflammatory mediators, through the upregulation of inducible genes that contribute to inflammatory responses [18, 19].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects ofHyptis albidaChloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages

et al. 2013

View full text Add to dashboard Cite

We examined the effects of a chloroform extract of Hyptis albida (CHA) on inflammatory responses in mouse lipopolysaccharide (LPS) induced peritoneal macrophages. Our findings indicate that CHA inhibits LPS-induced production of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6). During the process, levels of cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), and nitric oxide (NO) increased in the mouse peritoneal macrophages; however, the extract suppressed them significantly. These results provide novel insights into the anti-inflammatory actions of CHA and support its potential use in the treatment of inflammatory diseases.

show abstract

Anti-inflammatory effects of essential oil isolated from the buds of Cleistocalyx operculatus (Roxb.) Merr and Perry

Cited by 51 publications

References 21 publications

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Cholinesterase inhibitors from Cleistocalyx operculatus buds

Anti-Inflammatory Effects ofHyptis albidaChloroform Extract on Lipopolysaccharide-Stimulated Peritoneal Macrophages

Contact Info

Product

Resources

About