Anti-inflammatory effects of phenolic crude extracts from five fractions of Corchorus Olitorius L.

Yan, Yeong-Yu; YueWen, Wang; Chen, Su-Lin; Zhuang, Shu-Ru; Wang, Chin‐Kun

doi:10.1016/j.foodchem.2012.10.052

Cited by 33 publications

(26 citation statements)

References 23 publications

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“…The leaves of C. olitorius are consumed as a vegetable in some countries and as medicinal plant in other countries. Many investigators demonstrated that C. olitorius a safe herb, possess anti‐inflammatory, antioxidant activities and antihyperglycemic effect . Our study confirmed that the safety of C. olitorius was high, its orally LD50 in mice was very high (9.6 g/kg).…”

Section: Discussionsupporting

confidence: 84%

“…It contains different types of terpenes mainly phytol in complex with essential fatty acids and phenolic compounds . Many studies showed that it has good antioxidant and DPPH scavenging effects . Anti‐inflammatory, analgesic and antipyretic effects of the extract of C. olitorius have also been demonstrated in animals .…”

Section: Introductionmentioning

confidence: 99%

“…[7,8] Antiinflammatory, analgesic and antipyretic effects of the extract of C. olitorius have also been demonstrated in animals. [7,9,10] The anti-inflammatory effect of C. olitorius terpenes may modulate the low grade of inflammation associated with obesity. Accordingly, in the present study, we investigated the effect of C. olitorius leaf extract on obesity, dyslipidaemia and insulin resistance induced by high fat-high carbohydrate diet, whereas the ability of diet induced obesity rat model to predict clinically meaningful weight loss is excellent.…”

Section: Introductionmentioning

confidence: 99%

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Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives To determine the efficacy of Corchorus olitorius (C. olitorius) leaf extract in the prevention of metabolic syndrome induced in rats by high‐fat diet (HFD) and compare it with that of orlistat. Methods Phytochemical analysis was performed. Effect of orlistat and C. olitorius extract on lipase activity and acute food intake were investigated. Body weight, biochemical parameters and histopathological examination were demonstrated. Key findings Corchorus olitorius extract inhibited the pancreatic lipase activity, but orlistat was more potent. Cumulative food intake has not changed by the tested agents. In obese rats, C. olitorius or orlistat significantly decreased weight gain and visceral white adipose tissue. They exhibited a significant reduction in serum glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, free fatty acids, IL‐1β, tumour necrosis factor‐α (TNF‐α), insulin and leptin levels of obese rat groups while high density lipoprotein cholesterol and adiponectin levels were significantly increased by them. Histopathological examination of the liver revealed that C. olitorius was more effective than orlistat in the alleviating of steatosis and adipocyte hypertrophy shown in obese control rats. Conclusions Corchorus olitorius is effective as orlistat in preventing obesity, hyperlipidaemia, steatosis and insulin resistance. These actions may be mediated by inhibiting of lipase activity, TNF‐α, IL‐1β and leptin resistance along with increasing of adiponectin.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Gomaa

Elsers

Al-Zokeim

et al. 2019

Journal of Pharmacy and Pharmacology

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“…The data also demonstrate that cannabis extract is capable of significantly suppressing the expression of specific pro-inflammatory cytokine/chemokine in human dermal fibroblast cells. The study explains usefulness of LPS-stimulated in vitro systems for the evaluation of the anti-inflammatory properties of plant extracts using this methodological approach [45] [46]. To conclude, the data presented in this paper provide further support for the concept that traditional medicines, such as cannabis, can be valuable additions to the modern therapeutic armamentarium, and non-habit-forming cannabinoid agonist(s) which lack psychotropic activity may be used for the management of prostate cancer.…”

Section: Discussionmentioning

confidence: 54%

<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

Sharma¹,

Hudson²,

Adomat³

et al. 2014

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Cannabinoids, the active components of Cannabis sativa Linnaeus, have received renewed interest in recent years due to their diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects and tumor regression, but their use in chemotherapy is limited by their psychotropic activity. To date, cannabinoids have been successfully used in the treatment of nausea and vomiting, two common side effects that accompany chemotherapy in cancer patients. Most non-THC plant cannabinoids e.g. cannabidiol and cannabigerol, seem to be devoid of psychotropic properties. However, the precise pathways through which these molecules produce an antitumor effect have not yet been fully characterized. We therefore investigated the antitumor and anti-inflammatory activities of cannabidiol (CBD) in human prostate cancer cell lines LNCaP, DU145, PC3, and assessed whether there is any advantage in using cannabis extracts enriched in cannabidiol and low in THC. Results obtained in a panel of prostate cancer cell lines clearly indicate that cannabidiol is a potent inhibitor of cancer cell growth, with significantly lower potency in non-cancer cells. The mRNA expression level of cannabinoid receptors CB1 and CB2, vascular endothelial growth factor (VEGF), PSA (prostate specific antigen) are significantly higher in human prostate cell lines. Treatment with Cannabis extract containing high CBD down regulates CB1, CB2, VEGF, PSA, pro-inflammatory cytokines/chemokine IL-6/IL-8. Our overall findings support the concept that cannabidiol, which lacks psychotropic activity, may possess anti-inflammatory property and down regulates both cannabinoid receptors, PSA, VEGF, IL-6 and IL-8. High CBD cannabis extracts are cytotoxic to androgen responsive LNCaP cells and may effectively inhibit spheroid formation in cancer stem cells. This activity may contribute to its anticancer and chemosensitizing effect against prostate cancer. Cannabidiol and other non-habit forming cannabinoids could be used as novel therapeutic agents for the treatment of prostate cancer.

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“…For instance, 5-caffeoylquinic acid, quercetin, corchorifattys, and other glycosides found in C. olitorius are effective free radical scavengers and inhibitors of nitric oxide. [25][26][27] In addition, C. olitorius contains antitumor promoters such as phytol and monogalactosyl-diacylglycerol that have been shown to induce apoptosis and inhibit DNA polymerases in cancer cells. 28 Changes in hematological parameters have been reported to be early markers for monitoring tissue injury caused by certain toxicants.…”

Section: Discussionmentioning

confidence: 99%

Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats

Akinwumi

Osifeso²,

Jubril

et al. 2016

Journal of Medicinal Food

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Exposure to hexavalent chromate compounds such as other human carcinogens is unavoidable in the developing countries of the world. Research efforts are being directed toward minimizing exposure to them, intercepting their activity in vivo, and/or prophylaxis. The present study therefore evaluates the effect of methanol extract of the leafy vegetable, Corchorus olitorius (MECO), against potassium dichromate (K2Cr2O7)-induced toxicities. Negative control animals were fed distilled water, while the positive control rats received 12 mg/kg body weight K2Cr2O7 once a week for 6 weeks. Test rats were exposed daily to 25, 50, and 100 mg/kg body weight MECO alone for 6 weeks and 12 mg/kg body weight of K2Cr2O7 once a week for 6 weeks before sacrifice. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in bone marrow cells, while induction of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine levels, and hematological parameters were assessed in the plasma. The phytochemical analysis of MECO was also carried out. K2Cr2O7 significantly (P < .05) increased the levels of mPCEs, AST, ALT, creatinine, total white blood cells, and lymphocytes compared with the control. The percentage pack cell volume and neutrophils were, however, reduced. In contrast, MECO at different doses restored the markers toward the levels of the negative control. MECO is rich in flavonoids, saponins, anthraquinones, terpenoids, and phenols, and they might be responsible for the protective effect observed in this study. Our results suggest that MECO has a promising potential in the treatment/management of chromate-induced toxicities.

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Anti-inflammatory effects of phenolic crude extracts from five fractions of Corchorus Olitorius L.

Cited by 33 publications

References 23 publications

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats

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Anti-inflammatory effects of phenolic crude extracts from five fractions of Corchorus Olitorius L.

Cited by 33 publications

References 23 publications

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo/cytokines

&lt;i&gt;In Vitro&lt;/i&gt; Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats

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<i>In Vitro</i> Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines