Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp.

Marine natural products

“…[417][418][419] Pyrazole NPs 1019-1021 were reported from Cinachyrella sp., 403 while a Haliclona yielded three new 3-alkylpyridinium alkaloids 1022-1024. 420 New manzamine-type alkaloids appeared in three separate reports 1025-1032 from Acanthostrongylophora, Amphimedon and Lissodendoryx sponges. [421][422][423] An Indonesian Acanthostrongylophora sponge was also the source of a new b-carboline alkaloid 1033.…”

Recent Advances on Marine Alkaloids from Sponges

“…[83] Compounds 139 -141 were identified as cyclic pyridine alkaloids featured with a dimeric pyridine connected with long aliphatic chain, which were isolated from the Indonesian marine sponge Haliclona sp. [84] Compounds 142-147 were identified as polycyclic alkaloids. Compounds 142 and 143 were isolated from the culture of sponge Neopetrosia exigua.…”

Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona

“…Five new alkaloids, halitulin (27), halic isolorensin (29), isohaliclorensin (30), haliclorensin B (31) and haliclorensin C (32) together with isohalitulin (28) ( Figure 6), were purified from the sponge Haliclona tulearensis collected from Sodwana Bay (South Africa) [22][23][24]. Compound 29 was a novel diamino derivative possessing an azacyclodecane ring, and exhibited strong cytotoxicity against P-388 mouse leukemia cells with an IC 50 value of 0.1 mg/mL [21].…”

“…Haliclocyclamines A-C(42)(43)(44), three new cyclic bis-1,3-APA derivatives, found together with five analogs cyclostellettamines A-C(45)(46)(47), E(48) and F(49), were separated from the EtOH extract of Haliclona sp. collected at Manado in Indonesia (Figure 7)[29,30]. Compounds 44 and 49 could inhibit vaccinia H-1-related phosphatase (VHR) at 17-18 µM and compound 45 possessed cytotoxic effect on HeLa cells with an IC 50 value of 0.9 µg/mL and P388 cells with an IC 50 value of 1.06 µg/mL.…”