Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease

Wang, Yulin; Liu, Jing; Zhang, Zhongmin; Bi, Pengxiang; Zhou, Qi; Zhang, Chaodong

doi:10.1016/j.neulet.2010.09.076

Cited by 79 publications

(79 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we cannot exclude the possibility that the anti-oxidant properties (Y. H. Xie et al, 2007) and the anti-inflammatory activity (Wang et al, 2011) of Gn Rb1 may also contribute to its neuroprotective effect. Interestingly, Gn Rb1 has previously been shown to be a much more potent anti-oxidant than Rg1, while Rg3 was shown to promote the free radical-induced heamolysis in human red blood cells (Liu et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Ardah

Paleologou

et al. 2015

Neurobiology of Disease

View full text Add to dashboard Cite

Compelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the aggregation process may thus represent a viable therapeutic strategy against PD and related disorders. Ginseng is a well-known medicinal plant that has been used in East Asia for more than two thousand years to treat several conditions. It is now understood that the pharmacological properties of ginseng can be attributed to its biologically active components, the ginsenosides, which in turn have been shown to have neuroprotective properties. We therefore sought to determine for the first time, the potential of the most frequently used and studied ginsenosides, namely Rg1, Rg3 and Rb1, as anti-amyloidogenic agents. The effect of Rg1, Rg3 and Rb1 on α-syn aggregation and toxicity was determined by an array of biophysical, biochemical and cell-culture-based techniques. Among the screened ginsenosides, only Rb1 was shown to be a potent inhibitor of α-syn fibrillation and toxicity. Additionally, Rb1 exhibited a strong ability to disaggregate preformed fibrils and to inhibit the seeded polymerization of α-syn. Interestingly, Rb1 was found to stabilize soluble non-toxic oligomers with no β-sheet content, that were susceptible to proteinase K digestion, and the binding of Rb1 to those oligomers may represent a potential mechanism of action. Thus, Rb1 could represent the starting point for designing new molecules that could be utilized as drugs for the treatment of PD and related disorders.

show abstract

Section: Discussionmentioning

confidence: 93%

“…Xie et al, 2010). In animal models, Gn Rb1 was demonstrated to have anti-inflammatory activity (Wang et al, 2011) and to reduce soluble Aβ 40 in a dose-dependent fashion (Shi et al, 2010). Interestingly, Gn Rb1 was shown to attenuate the Aβ 25-35 -induced hyperphosphorylation of tau protein in vitro (Y.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Ardah

Paleologou

et al. 2015

Neurobiology of Disease

View full text Add to dashboard Cite

show abstract

“…Ginsenoside is one of the main active ingredients of ginseng (Panax ginseng Meyer), and the chemistry, pharmacology, and other aspects of ginseng have been studied systemically and in-depth in modern medicine. So far, more than 40 ginsenosides have been isolated from the whole plant and processed ginseng, which have been demonstrated to have some biological activities, such as immune regulation, antiaging, antidementia, and improvement of cerebral ischemia-reperfusion injury (Cheng et al 2005;Wang et al 2011;Kim et al 2012); of which, ginsenoside Rg3, Rg1, Rh1, Rb1, and other components show a significant antitumor effect mainly by promoting the apoptosis of tumor cells, blocking the metastasis of tumor cells, inhibiting the angiogenesis of tumor, reversing the multidrug resistance of tumors, and affecting the expression of cancer genes related to the tumor signal transduction, and particularly, play a prominent role in reducing side effects of the chemotherapy and improving the sensitivity of tumor cells to chemotherapeutic drugs in cancer patients (Lee et al 2003;Lau et al 2009;Park et al 2014). CK, i.e., 20 (S)-O-b-D-glucoside protopanaxadiol (the chemical structure is shown in Figure 1) is an active metabolite of ginsenosides in vivo, having shown some significant effects, such as a hypoglycemic effect, antiinflammatory activity, improving immunity, liver protection, and antitumor Lee et al 2014;Mathiyalagan et al 2014;Wu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Effects of ginsenoside compound K combined with cisplatin on the proliferation, apoptosis and epithelial mesenchymal transition in MCF-7 cells of human breast cancer

Zhang

2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Breast cancer seriously harms the health of women and there are currently few therapeutic options for patients with breast cancer. Objective: Effects of ginsenoside compound K (CK) in combination with cisplatin (DDP) on the proliferation, apoptosis, and epithelial mesenchymal transition (EMT) of MCF-7 cells were studied. Materials and methods: MCF-7 cells were divided into CK (50 mmol/L) group, DDP (10 mg/L) group, CK (50 mmol/L) +DDP (10 mg/L) group, and control (CON) group. The cells in the CON group were not treated with any drugs. Proliferation, apoptosis, expression of E-cadherin, N-cadherin, vimentin, protein kinase B (Akt), phosphorylated Akt (p-Akt), and level of fibronectin (FN) in MCF-7 cells were detected by methyl thiazolyl tetrazolium (MTT), flow cytometry, western blotting, and enzyme-linked immuno sorbent assay (ELISA), respectively. Results: The proliferation inhibition rates in CK, DDP, and CK + DDP groups at 48 h were 19.18 ± 2.25, 21.34 ± 2.84, and 43.37 ± 5.62, respectively. The apoptosis rates were 2.85 ± 0.56, 13.37 ± 2.28,

show abstract

“…Rb1 improved AD by increasing brain-derived neurotrophic factor and decreasing Tau protein [8] and protected neuronal cells from injury with β-amyloid (Aβ) treatment [9], [10]. Additionally, Rb1 demonstrated anti-neuroinflammation effects in a rat model of AD [11].…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells

Hwang

Shim

Song

et al. 2016

Journal of Ginseng Research

View full text Add to dashboard Cite

BackgroundThe ginsenoside Rb1 (Rb1) is the most abundant compound in the root of Panax ginseng. Recent studies have shown that Rb1 has a neuroprotective effect. However, the mechanisms underlying this effect are still unknown.MethodsWe used stable isotope labeling with amino acids in cell culture, combined with quantitative mass spectrometry, to explore a potential protective mechanism of Rb1 in β-amyloid-treated neuronal cells.ResultsA total of 1,231 proteins were commonly identified from three replicate experiments. Among these, 40 proteins were significantly changed in response to Rb1 pretreatment in β-amyloid-treated neuronal cells. Analysis of the functional enrichments and protein interactions of altered proteins revealed that actin cytoskeleton proteins might be linked to the regulatory mechanisms of Rb1. The CAP1, CAPZB, TOMM40, and DSTN proteins showed potential as molecular target proteins for the functional contribution of Rb1 in Alzheimer's disease (AD).ConclusionOur proteomic data may provide new insights into the protective mechanisms of Rb1 in AD.

show abstract

Anti-neuroinflammation effect of ginsenoside Rbl in a rat model of Alzheimer disease

Cited by 79 publications

References 12 publications

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Effects of ginsenoside compound K combined with cisplatin on the proliferation, apoptosis and epithelial mesenchymal transition in MCF-7 cells of human breast cancer

Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells

Contact Info

Product

Resources

About