Anti‐neurotoxic evaluation of synthetic and characterized metal complexes of thiosemicarbazone derivatives

Abstract

Quinoline-2-caboxyaldehyde thiosemicarbazone (HL 1 ) and quinoline -2caboxyaldehyde N-dimethyl thiosemicarbazone (HL 2 ) metal complexes were prepared and characterized using analytical and spectroscopic techniques. The measurements showed that ligands behave as monovalent or neutral tridentate ligands bonding via azomethine, quinoline ring nitrogen atoms and sulfur atoms in thiol or thion forms. The anti-neurotoxic effect of ligands and their complexes showed that, exposure to aluminum increase oxidative stress in the brain, an effect that could be offset by concomitant thiosemicarbazone complexes. Complexes could be having an effect on absorption or excretion of aluminum, due to their chelating activity. These findings may shed light on the potential clinical importance of thiosemicarbazone complexes in Alzheimer's disease.

Synthesis, characterization, and density functional theory studies of hydrazone–oxime ligand derived from 2,4,6‐trichlorophenyl hydrazine and its metal complexes searching for new antimicrobial drugs

“…[18] Pilichos et al studied the coordination and metal ion-mediated transformation of a polydentate ligand containing oxime, hydrazone, and picolinoyl functionalities [19] while Drover et al described the preparation and characterization of tetranuclear, binuclear, and chain complexes with a hydrazone-oxime and hydrazone series. [20] Because of the interesting bioactivities of compounds incorporating both oxime and hydrazone moieties and for continuing of our previous work to explore the biological activities of metal complexes, [21][22][23][24][25][26] this research was devoted to the synthesis of new hydrazone-oxime derived from 2,4,6-trichlorophenyl hydrazine and its Cd 2+ , Zn 2+ , Cu 2+ , Ni 2+ , Co 2+ , Fe 3+ , Mn 2+ , and VO 2+ complexes. The investigation of prepared compounds structure was done via spectral, analytical, and theoretical techniques such as infrared (IR), nuclear magnetic resonance (NMR), mass, electron spin resonance (ESR), and electronic absorption spectrum (EAS) as well as elemental, thermal and density functional theory (DFT) studies in addition to the magnetic and molar conductance measurements for complexes.…”

Iron(II) and cobalt(II) Complexes of 3,4‐Dihydroxybenzaldehyde‐4‐ethylthiosemicarbazone: Synthesis, Spectral Studies and Molecular Docking

“…[15] Cu(II), Co(II), Mn(II), Fe(III), Cr(III) and Al(III) complexes of quinolone-2-caboxyaldehyde thiosemicarbazone and quinolone-2-caboxyaldehyde N-dimethyl thiosemicarbazone have been reported as antineurotoxic agents. [16] In addition, cytotoxicity of half-sandwich iridium complexes with thiosemicarbazone ligands against HeLa cervical carcinoma, HepG2 liver carcinoma, CNE-2 nasopharyngeal carcinoma, SGC-7901 gastric carcinoma, KB oral epithelial carcinoma and HEK-293 T embryonic kidney cell lines have been evaluated. The complexes displayed remarkable antiproliferative activity.…”

“…Ruthenium complexes of 5‐nitro‐2‐carboxyaldehyde‐thiophen‐N‐methyl‐thiosemicarbazone, 2‐acetyl‐5‐bromo‐thiophen‐N‐methyl‐thiosemicarbazone and 2‐acetyl‐5‐bromo‐thiophen‐N,N‐dimethyl‐thiosemicarbazone showed anticancer activity on primary (A2780) and metastatic (OVCAR‐3) ovarian cancer cells [15] . Cu(II), Co(II), Mn(II), Fe(III), Cr(III) and Al(III) complexes of quinolone‐2‐caboxyaldehyde thiosemicarbazone and quinolone‐2‐caboxyaldehyde N ‐dimethyl thiosemicarbazone have been reported as antineurotoxic agents [16] . In addition, cytotoxicity of half‐sandwich iridium complexes with thiosemicarbazone ligands against HeLa cervical carcinoma, HepG2 liver carcinoma, CNE‐2 nasopharyngeal carcinoma, SGC‐7901 gastric carcinoma, KB oral epithelial carcinoma and HEK‐293 T embryonic kidney cell lines have been evaluated.…”

Synthesis and Characterization of Novel Calix[4]arene Schiff Base Derivatives and Cytotoxicity Effect Evaluation on Cancer Cell Lines

“…Because its active group (-N=CH-) contains active electrons, Schiff bases are excellent candidates for the development of novel medications [11][12]. Because of their extensive variety of pharmacokinetic properties and their popularity in drug development programs, the derivatives of Schiff bases represent a large category of substances that have found several applications in medicinal chemistry [13][14].…”