2008
DOI: 10.3923/jpt.2009.17.29
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Anti-Nociceptive Effects of an Ethanolic Extract of the Whole Plant of Synedrella nodiflora (L.) Gaertn in Mice: Involvement of Adenosinergic Mechanisms

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Cited by 20 publications
(24 citation statements)
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“…[3] The whole plant extract have been reported to possess potent anti-inflammatory, [4] antibacterial and antioxidant [5] and antinociceptive. [6] Free radicals and associated lipid peroxidation are implicated in epilepsy and inflammation [7] and the role of antioxidants in the management of conditions caused by oxidative stress have been reported. [8][9][10][11] We have demonstrated the anticonvulsant effects of the hydro-ethanolic extract of the plant in our laboratory.…”
Section: Free Radical Scavenging and Anti-lipid Peroxidative Effects mentioning
confidence: 99%
“…[3] The whole plant extract have been reported to possess potent anti-inflammatory, [4] antibacterial and antioxidant [5] and antinociceptive. [6] Free radicals and associated lipid peroxidation are implicated in epilepsy and inflammation [7] and the role of antioxidants in the management of conditions caused by oxidative stress have been reported. [8][9][10][11] We have demonstrated the anticonvulsant effects of the hydro-ethanolic extract of the plant in our laboratory.…”
Section: Free Radical Scavenging and Anti-lipid Peroxidative Effects mentioning
confidence: 99%
“…This paw pressure test was conducted according to the method described by Woode et al 21 and Zakaria et al 22 The rats were placed on the Ugo Basile dynamic plantar aesthesiometer for 20 minutes prior to the experiment to enable them to adapt to their surroundings. Around 30 minutes after oral administration of the treatment drug, 50 μL of 1% carrageenan was injected into their right hind paws via intraplantar injection.…”
Section: Randall-sellito Paw Pressure Test (Mechanical Hyperalgesia)mentioning
confidence: 99%
“…The highest therapeutic dose of the hydro-ethanolic extract demonstrating anticonvulsant and related neuropharmacological properties is lower (i.e. 1000 mg kg -1 ) (Woode et al, 2009, Amoateng et al, 2012, than the doses used in this study (which are 1600, 3200 and 6400 mg kg -1 ). Thus this present study only demonstrates the effects of acute administration of high doses of the extract beyond 1000 mg kg -1 .…”
Section: Parametermentioning
confidence: 52%
“…The hydro-ethanolic extract of the whole plant has been found to possess anticonvulsant (Amoateng et al, 2012), sedative (Woode et al, 2011), in vitro antioxidant and free radical scavenging properties and anti-nociceptive properties (Woode et al, 2009). To explore the plant for further pre-clinical anti-epileptic drug discovery and development, it is important to investigate the toxicity of the plant.…”
Section: Introductionmentioning
confidence: 99%