Anti-Obesity and Hypolipidemic Effects ofLycium chinenseLeaf Powder in Obese Rats

Abstract

This study aimed to elucidate the obesity control, hypolipidemic, and antioxidant effects of Lycium chinense leaf powder intake by obese rats. Obesity was induced in rats through 13 weeks of high-fat diet. The obese rats were then divided into four different groups, which were fed for 8 weeks with general diet (G), high-fat diet (F), 5% L. chinense leaf powder with a high-fat diet (FLP5), or 10% L. chinense leaf powder with a high-fat diet (FLP10). The body weight gain of the FLP5 group was significantly lower than that of the F group. Also, the obesity index of the FLP5 and FLP10 group was significantly lower than that of the F group. Serum triglyceride and low-density lipoprotein (LDL)-cholesterol levels in the FLP5 group were significantly lower than those of the F group. The intake of L. chinense leaf powder did not seem to significantly affect the levels of serum homocysteine, leptin, and ghrelin compared to the control group without L. chinense leaf powder intake. The glutathione content in the liver was significantly higher in the FLP5 group than in the G group, but the glutathione S-transferase activity was significantly lower than in the F group. The thiobarbituric acid-reactive substances levels in the liver and kidney were relatively lower in the FLP5 and FLP10 groups than in the G group. In summary, intake of L. chinense leaf powder in obese rats coincided with a lowering of body weight and levels of serum triglyceride and LDL-cholesterol. It also displayed antioxidant effects.

Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin‐Nicotinamide Induced Diabetic Rats

“…The effect might be mediated via its antioxidant and free radical scavenging activity. [ ][ ] Previous studies have documented that STZ induced diabetes leads to significant body weight loss. The loss of weight experience in diabetic situation had been attributed to the breakdown and use of available proteins and fats as energy source due to the inability of the body to utilize glucose for energy .…”

Selenium increases chlorogenic acid, chlorophyll and carotenoids of Lycium chinense leaves

“…Polyphenols are the important active compounds in L. chinense leaves and are highly beneficial for health protection . Nowadays, L. barbarum has been widely cultivated in north‐west China; fruits and leaves of L. barbarum were used as medicinal food and functional tea.…”

Betaine Supplementation Improves Beneficial Effects of Boxthorn (L ycium chinense Mill.) Leaf on Body Weight/Body Fat Increase and Plasma/Liver Triglycerides Accumulation in High-Fat Diet-Fed C57BL/6 Mice

“…Antiobesity and hypolipidemic effects of L. chinense leaf powder were reported previously (Kang et al . ). In this report, dietary supplementation of L. chinense leaf powder was shown to suppress body weight gain and lower serum triglyceride and LDL cholesterol levels.…”

“…Antiobesity and hypolipidemic effects of L. chinense leaf powder was also reported previously (Kang et al . ). Betaine, an oxidative metabolite of choline, was well known for its ability to protect animals against fatty liver (Patrick ; Wang et al .…”