Anti-Osteoporotic Effects of Antioxidant Peptides PIISVYWK and FSVVPSPK from Mytilus edulis on Ovariectomized Mice

Oh, Yunok; Ahn, Chang‐Bum; Cho, Won Ho; Yoon, Na Young; Je, Jae‐Young

doi:10.3390/antiox9090866

Cited by 20 publications

(8 citation statements)

References 30 publications

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“…Apoptosis of osteoblasts and osteocytes with decreased osteoblast count can be induced by oxidative stress due to the activation of nuclear transcription factor kB (NF-kB) and extracellular signal-regulated kinases (ERK) signaling pathways [ 25 ], which represses the bone formation rate via Wnt/β-catenin signaling pathways in osteoblastogenesis [ 26 ]. ROS is involved in bone resorption through direct bone degradation by osteoclast-generated superoxide or through enhancement of osteoclast differentiation and function [ 22 , 23 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Osteoporosismentioning

confidence: 99%

Osteoprotective Roles of Green Tea Catechins

et al. 2020

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Osteoporosis is the second most common disease only secondary to cardiovascular disease, with the risk of fracture increasing with age. Osteoporosis is caused by an imbalance between osteoblastogenesis and osteoclastogenesis processes. Osteoclastogenesis may be enhanced, osteoblastogenesis may be reduced, or both may be evident. Inflammation and high reactive oxygen enhance osteoclastogenesis while reducing osteoblastogenesis by inducing osteoblast apoptosis and suppressing osteoblastic proliferation and differentiation. Catechins, the main polyphenols found in green tea with potent anti-oxidant and anti-inflammatory properties, can counteract the deleterious effects of the imbalance of osteoblastogenesis and osteoclastogenesis caused by osteoporosis. Green tea catechins can attenuate osteoclastogenesis by enhancing apoptosis of osteoclasts, hampering osteoclastogenesis, and prohibiting bone resorption in vitro. Catechin effects can be directly exerted on pre-osteoclasts/osteoclasts or indirectly exerted via the modulation of mesenchymal stem cells (MSCs)/stromal cell regulation of pre-osteoclasts through activation of the nuclear factor kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. Catechins also can enhance osteoblastogenesis by enhancing osteogenic differentiation of MSCs and increasing osteoblastic survival, proliferation, differentiation, and mineralization. The in vitro effects of catechins on osteogenesis have been confirmed in several animal models, as well as in epidemiological observational studies on human subjects. Even though randomized control trials have not shown that catechins provide anti-fracture efficacy, safety data in the trials are promising. A large-scale, placebo-controlled, long-term randomized trial with a tea regimen intervention of optimal duration is required to determine anti-fracture efficacy.

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Section: Osteoporosismentioning

confidence: 99%

Osteoprotective Roles of Green Tea Catechins

et al. 2020

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“…To date, many BAPs have been isolated and identified from marine dietary protein hydrolysates [27]. In addition, previous studies have identified specific BAPs in blue mussel protein hydrolysates that have been attributed antioxidant, antithrombotic, antihypertensive, osteogenic, and anti-osteoporotic effects [19,20,[28][29][30][31]. Blue mussel protein hydrolysate produced by α-chymotrypsin has been previously identified as a potential cytoprotective agent [1].…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective Peptides from Blue Mussel Protein Hydrolysates: Identification and Mechanism Investigation in Human Umbilical Vein Endothelial Cells Injury

Suryaningtyas

Ahn

2021

Marine Drugs

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Cardiovascular disease represents a leading cause of mortality and is often characterized by the emergence of endothelial dysfunction (ED), a physiologic condition that takes place in the early progress of atherosclerosis. In this study, two cytoprotective peptides derived from blue mussel chymotrypsin hydrolysates with the sequence of EPTF and FTVN were purified and identified. Molecular mechanisms underlying the cytoprotective effects against oxidative stress which lead to human umbilical vein endothelial cells (HUVEC) injury were investigated. The results showed that pretreatment of EPTF, FTVN and their combination (1:1) in 0.1 mg/mL significantly reduced HUVEC death due to H2O2 exposure. The cytoprotective mechanism of these peptides involves an improvement in the cellular antioxidant defense system, as indicated by the suppression of the intracellular ROS generation through upregulation of the cytoprotective enzyme heme oxygenase-1. In addition, H2O2 exposure triggers HUVEC damage through the apoptosis process, as evidenced by increased cytochrome C release, Bax protein expression, and the elevated amount of activated caspase-3, however in HUVEC pretreated with peptides and their combination, the presence of those apoptotic stimuli was significantly decreased. Each peptide showed similar cytoprotective effect but no synergistic effect. Taken together, these peptides may be especially important in protecting against oxidative stress-mediated ED.

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“…45 Previous research has shown that mussel peptides, ginsenosides Rg3, and Palmul-tang (an herbal remedy) could decrease osteoporosis by activating the BMP-2 pathway and promoting the expression of critical factors in osteoblasts. [46][47][48] In this study, the effect of P-GM-1 on the expression of BMP-2 and other important bone transcription factors in OVX-mice was further determined. The results are shown in Fig.…”

Section: Papermentioning

confidence: 99%