Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates

Alibí, Sana; Selma, Walid Ben; Ramos-Vivas, José; Smach, Mohamed Ali; Touati, Ridha; Boukadida, Jalel; Navas, Jesús; Mansour, Hédi Ben

doi:10.1016/j.retram.2020.01.001

Cited by 70 publications

(45 citation statements)

References 59 publications

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“…Other essential oils also regulate the expression of genes involved in biofilm formation and biofilm dispersal. For example, essential oils from thyme, cinnamon, and clove exhibited a high antibiofilm activity against many bacteria, including ESKAPE bacteria [257]. Cinnamon oil was earlier proven to inhibit the production of rhamnolipids, proteases, and alginate as well as swarming motility in P. aeruginosa [256], which is consistent with inhibition of QS.…”

Section: Antimicrobial Substancesmentioning

confidence: 75%

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

et al. 2020

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Multidrug resistant bacteria are a global threat for human and animal health. However, they are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to their capacity to withstand antimicrobials is the formation of biofilms. Biofilms are associations of microorganisms embedded a self-produced extracellular matrix. They create particular environments that confer bacterial tolerance and resistance to antibiotics by different mechanisms that depend upon factors such as biofilm composition, architecture, the stage of biofilm development, and growth conditions. The biofilm structure hinders the penetration of antibiotics and may prevent the accumulation of bactericidal concentrations throughout the entire biofilm. In addition, gradients of dispersion of nutrients and oxygen within the biofilm generate different metabolic states of individual cells and favor the development of antibiotic tolerance and bacterial persistence. Furthermore, antimicrobial resistance may develop within biofilms through a variety of mechanisms. The expression of efflux pumps may be induced in various parts of the biofilm and the mutation frequency is induced, while the presence of extracellular DNA and the close contact between cells favor horizontal gene transfer. A deep understanding of the mechanisms by which biofilms cause tolerance/resistance to antibiotics helps to develop novel strategies to fight these infections.

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Section: Antimicrobial Substancesmentioning

confidence: 75%

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

et al. 2020

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“…Similarly, strong biofilm and quorum sensing inhibitory activities were reported from EOs of T. daenensis and Satureja hortensis against S. aureus ( Sharifi et al, 2018 ) . A study by Alibi et al (2020) have demonstrated the successful application of the EOs from Cinnamomum verum , Thymus vulgaris and Eugenia caryophyllata against to inhibit growth of 105 MDR clinical isolates via significant anti-biofilm and anti-quorum sensing activities.…”

Section: Phytochemicals For Combating Antibiotic Resistancementioning

confidence: 99%

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

et al. 2021

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Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.

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“…For example, degradation of a self-inducing molecule in P. aeruginosa in presence of azithromycin prevents biofilm formation, inhibits virulence factors expression and reduces growth rate by up to 90% at three sub-MICs (Cui et al, 2020). Essential oils of cinnamon, clove, thyme and marjoram exhibited high antibiofilm, antioxidant and anti-quorum sensing activities against clinical isolates of E. coli, K. pneumoniae, A. baumanii, S. aureus, and P. aeruginosa (Alibi et al, 2020). Nanoparticles and bacteriocins also act as quorum sensing inhibitors (Melian et al, 2019;Ali et al, 2020).…”

Section: Anti-virulence Drugsmentioning

confidence: 99%

“…aureus , and P . aeruginosa ( Alibi et al, 2020 ). Nanoparticles and bacteriocins also act as quorum sensing inhibitors ( Melian et al, 2019 ; Ali et al, 2020 ).…”

Section: Novel Therapeutic Approachesmentioning

confidence: 99%

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

2021

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Rising antibiotic resistance is a global threat that is projected to cause more deaths than all cancers combined by 2050. In this review, we set to summarize the current state of antibiotic resistance, and to give an overview of the emerging technologies aimed to escape the pre-antibiotic era recurrence. We conducted a comprehensive literature survey of >150 original research and review articles indexed in the Web of Science using “antimicrobial resistance,” “diagnostics,” “therapeutics,” “disinfection,” “nosocomial infections,” “ESKAPE pathogens” as key words. We discuss the impact of nosocomial infections on the spread of multi-drug resistant bacteria, give an overview over existing and developing strategies for faster diagnostics of infectious diseases, review current and novel approaches in therapy of infectious diseases, and finally discuss strategies for hospital disinfection to prevent MDR bacteria spread.

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Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates

Cited by 70 publications

References 59 publications

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens

Fighting Antibiotic Resistance in Hospital-Acquired Infections: Current State and Emerging Technologies in Disease Prevention, Diagnostics and Therapy

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