Anti-Oxidative, Anti-Hyperglycemic and Lipid-Lowering Effects of Aqueous Extracts of &amp;lt;i&amp;gt;Ocimum sanctum&amp;lt;/i&amp;gt; L. Leaves in Diabetic Rats

Suanarunsawat, Thamolwan; Ayutthaya, Watcharaporn Devakul Na; Thirawarapan, Suwan; Poungshompoo, Somlak

doi:10.4236/fns.2014.59090

Cited by 12 publications

(13 citation statements)

References 37 publications

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“…Our previous study showed that a diet containing 2% OS leaf powder resulted in a significant reduction in blood glucose levels in streptozotocin-induced DM rats ( 14 ). The administration of aqueous and alcoholic extracts of OS leaves also resulted in reduced blood glucose levels in streptozotocin-induced DM rats ( 15 , 16 ), and prevented insulin resistance in normal rats fed with a fructose diet ( 17 ). Prior studies have suggested that OS leaf extracts possess anti-hyperglycemic activity, in addition to protecting organs against various stress conditions such as hyperlipidemia ( 6 ), inflammation ( 18 ), cancer ( 19 ) and heavy metal toxicity ( 20 , 21 ).…”

Section: Introductionmentioning

confidence: 96%

“…Prior studies have suggested that OS leaf extracts possess anti-hyperglycemic activity, in addition to protecting organs against various stress conditions such as hyperlipidemia ( 6 ), inflammation ( 18 ), cancer ( 19 ) and heavy metal toxicity ( 20 , 21 ). Furthermore, an aqueous extract of OS leaves has been shown to promote antioxidative activity, thus protecting various organs against DM ( 16 , 22 ). OS leaves are known to be a rich source of volatile and fixed oils.…”

Section: Introductionmentioning

confidence: 99%

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Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats

Suanarunsawat

Anantasomboon

Piewbang

2016

Experimental and Therapeutic Medicine

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Ocimum sanctum L. (OS) leaves have been shown to exert diverse potential benefits in a variety of stress conditions. The present study was conducted to elucidate the effects of the fixed oil extracted from OS leaves on the blood glucose levels and serum lipid profile of streptozotocin-induced diabetic rats. In addition, the anti-oxidative activity of OS leaves to protect various organs including the liver, kidney and heart was investigated. The fixed oil of the OS leaves was extracted using hexane, and the various fatty acid contents of the oil were determined using gas chromatography-mass spectrometry. Male Wistar rats were allocated into three groups (n=7 per group): Normal control rats, diabetic rats and diabetic rats fed daily with the fixed oil for three weeks. The results showed that α-linolenic acid was the primary fatty acid contained in the fixed oil of OS. After 3 weeks of diabetic induction, the rats exhibited increased blood glucose levels and serum lipid profile, in addition to elevated serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase MB subunit (CK-MB), creatinine and blood urea nitrogen (BUN). The fixed oil significantly decreased the elevated levels of blood glucose, the serum lipid profile and the levels of serum creatinine and BUN (P<0.001), without exerting significant effects on the elevated serum levels of AST, ALT, LDH and CK-MB. Furthermore, the fixed oil increased the diabetically-reduced levels of serum insulin and decreased the rat kidney weight. Fixed oil suppressed the elevated thiobarbituric acid reactive substances (TBARS) level and increased the activity of various antioxidative enzymes in the rat renal tissue. By contrast, the fixed oil had no effect on the elevated TBARS level and the inhibited activity of the antioxidative enzymes in the rat liver and cardiac tissues. Histopathological results indicated that the fixed oil preserved the renal tissue against oxidative stress in diabetes. In summary, the results of the present study suggest that the fixed oil extracted from OS leaves exerted anti-hyperglycemic, anti-hyperlipidemic and free radical scavenging effects in diabetic rats, thus providing renal protection against diabetes. The α-linolenic acid contained in the fixed oil may be responsible for these effects.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats

Suanarunsawat

Anantasomboon

Piewbang

2016

Experimental and Therapeutic Medicine

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“…Tulsi exhibits antidiabetic activity, as was revealed in one study, it was observed that aqueous extract of Tulsi significantly lowers the blood glucose level in diabetic rats [8,79]. Similarly, other studies also confirm a fall of fasting blood sugar level and HBA1c was also contributed by the hypoglycemic effect of Tulsi [80,81].…”

Section: Antidiabetic Activitymentioning

confidence: 56%

Pharmacological Evaluation of Ocimum sanctum

Bano¹,

Ahmed²,

Tanveer³

et al. 2017

J Bioequiv Availab

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“…Available potassium (K) concentration was determined using 1 M Ammonium Acetate. Particle-size distribution was determined by the hydrometer method (Kruma et al, 2008;Suanarunsawat et al, 2014). The experiment was conducted in a factorial randomized complete design with three replications.…”

Section: Methodsmentioning

confidence: 99%

Effect of Heavy Metals Stress on Polyphenolic Compounds in Hydroalcoholic Extract of Basil (Ocimum basilicum L.)

2019

JSTR

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Heavy metals are important environmental pollutants and can affect the lives of plants and subsequently the lives of humans and other organisms. On the other hand, medicinal plants and their polyphenolic constituents have received much attention due to their confirmed positive effects on human health. Therefore, in this study, the effect of heavy metal lead, one of the most important toxic metals in the environment, on the polyphenolic compounds of the basil medicinal plant (Ocimum basilicum L.) was investigated. The purpose of this study was to evaluate the resistance of this medicinal plant to stress induced by lead toxic metal and also the content of polyphenolic compounds. The method was planted in basil greenhouse and factorial experiment in a completely randomized design with three replications. Lead metal treatment with 0, 25, 50 and 75 ppm levels, EDTA treatment with 0 and 1 mmol L-1 and humic acid treatment with 0 and 2 kg ha-1 were applied. After harvesting at flowering stage, the hydroalcoholic extract of dry shoots was prepared and the amount of polyphenolic compounds in the extracts was measured. The results showed that lead in soil significantly changed the content of polyphenolic compounds of basil. Increasing the amount of lead metal generally decreased the polyphenolic compounds of the plant. The presence of EDTA also increased polyphenolic compounds and reduced the content of polyphenolic compounds using humic acid.

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Anti-Oxidative, Anti-Hyperglycemic and Lipid-Lowering Effects of Aqueous Extracts of <i>Ocimum sanctum</i> L. Leaves in Diabetic Rats

Cited by 12 publications

References 37 publications

Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats

Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats

Pharmacological Evaluation of Ocimum sanctum

Effect of Heavy Metals Stress on Polyphenolic Compounds in Hydroalcoholic Extract of Basil (Ocimum basilicum L.)

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