Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine

Porobic, J Martinuc; Avčin, Tadej; Božič, Borut; Kuhar, Marijana; Čučnik, Saša; Zupančič, Mirjana; Prosenc, Katarina; Kveder, T; Rozman, B

doi:10.1111/j.1365-2249.2005.02923.x

Cited by 50 publications

(21 citation statements)

References 20 publications

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“…Moreover, one subject who initially had low positive IgG for anti-2 -GPI showed a progressive increase of the antibody level during 6 months of follow-up. Despite the fact that our results generally do not support a clear-cut influence of hepatitis B vaccine on aPL induction, the risk of developing a continuous long-term aPL response in genetically predisposed individuals can not be excluded [48].…”

Section: Antiphospholipid Antibodies In Response To Immunizationscontrasting

confidence: 80%

“…Our group performed a prospective longitudinal study in 85 healthy volunteers after immunization with recombinant DNA hepatitis B vaccine [48]. We observed a transient increase of aCL titers in two participants and a transient increase of anti-2 -GPI titers in one participant [48]. Moreover, one subject who initially had low positive IgG for anti-2 -GPI showed a progressive increase of the antibody level during 6 months of follow-up.…”

Section: Antiphospholipid Antibodies In Response To Immunizationsmentioning

confidence: 95%

“…Minimal accurate information exists regarding the induction of the synthesis of aPL following routine immunizations in humans, but useful data are beginning to emerge. Our group performed a prospective longitudinal study in 85 healthy volunteers after immunization with recombinant DNA hepatitis B vaccine [48]. We observed a transient increase of aCL titers in two participants and a transient increase of anti-2 -GPI titers in one participant [48].…”

Section: Antiphospholipid Antibodies In Response To Immunizationsmentioning

confidence: 97%

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Antiphospholipid antibodies in response to infection

Avčin

Toplak²

2007

Curr Rheumatol Rep

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An association between infections and antiphospholipid antibodies (aPL) has been reported in several epidemiologic and experimental studies. Infection-induced aPL have been traditionally regarded as transient and were generally not associated with clinical features of antiphospholipid syndrome. The distinction between autoimmune and postinfectious aPL on the basis of requirement of binding cofactor is not absolute, and in recent years, several reports demonstrated that some patients can produce pathogenic antibodies in response to infection. Infections most frequently associated with antiphospholipid syndrome include parvovirus B19, cytomegalovirus, varicella-zoster virus, HIV, streptococcal and staphylococcal infections, gram-negative bacteria, and Mycoplasma pneumoniae.

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Section: Antiphospholipid Antibodies In Response To Immunizationscontrasting

confidence: 80%

Section: Antiphospholipid Antibodies In Response To Immunizationsmentioning

confidence: 95%

Section: Antiphospholipid Antibodies In Response To Immunizationsmentioning

confidence: 97%

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Antiphospholipid antibodies in response to infection

Avčin

Toplak²

2007

Curr Rheumatol Rep

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“…This can lead to presentation of autoantigens and activation of autoreactive T cells (34). It is a known fact that the early induction of IFN-gamma may reflect the presence of activated natural killer cells, while the later response may be the product of antigen-specific T cells (35).…”

Section: Discussionmentioning

confidence: 99%

Development of autoimmune process in rats immunized with influenza vaccine

Leonavičienė¹,

Bradūnaitė²,

Vasiliauskas³

et al. 2009

Acta medica Lituanica

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Background. The role of vaccination in the development of autoimmunity has been extensively discussed in the literature; nevertheless, it remains vague. Whether there is a causal relationship between vaccination and the mechanisms leading to the autoimmune phenomena has yet to be discovered. Therefore, characterization of autoimmune disease in Wistar rats immunized with influenza vaccine was the basis of the current report. Materials and methods. Forty-three Wistar male rats (30 with AA and 13 healthy) were used. Two groups of animals with adjuvant arthritis (AA) and one group of healthy rats were immunized intramuscularly (i.m.) four times with 0.01 ml of influenza vaccine. Prophylactic and therapeutic vaccinations were made. Untreated groups (with AA and healthy) served as controls. Body and organ weight, blood and pro/antioxidant system indices in serum, joint swelling, development of polyarthritis, as well as histological changes in joints, liver and lungs were evaluated. Results. A more aggressive pathological process with elevated ESR and MDA levels and histological changes in the lungs and liver were observed in vaccinated animals. Despite a significant joint swelling and changes in periarticular soft tissues (increase of inflammatory infiltration, edema and angiomatosis), changes in the synovium and cartilage of vaccinated animals did not differ from those in AA controls, although the therapeutic vaccination induced more pronounced edema and inflammatory infiltration with granulocytes and macrophages in synovium, fissures (in 30% of animals), enhanced the rise of erosium (by 13.9%), usures (by 31.6%) and the thinning of cartilage (by 25%). We failed to detect any evidence of a clinically observed autoimmune process in healthy rats after vaccination, except only minimal histological changes in joints of some animals. Conclusions. Our preliminary findings are the first to show the presence of a certain relationship between vaccination and the exacerbation of autoimmune disease. The use of commercial influenza vaccine enhances the autoimmune process expressed by increased joint swelling and changes in soft periarticular tissues of experimental animals, and induces changes in the lungs. A greater impairment was observed after therapeutic vaccination.

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“…The induction of aPLs following vaccination with recombinant DNA hepatitis B vaccine was investigated in 85 healthy volunteers who were medical Vaccination of healthy subjects and autoantibodies: from mice through dogs to humans N Toplak and T Avčin students. 19 A transient increase of aCL titers in two participants and a transient increase of anti-b 2 -GPI titers in one participant were observed. One participant who initially had low positive IgG anti-b 2 -GPI showed a progressive increase of the antibody level during 6 months of follow up.…”

Section: Vaccination and Autoantibodies In Healthy Subjectsmentioning

confidence: 94%

Vaccination of healthy subjects and autoantibodies: from mice through dogs to humans

Toplak

Avčin

2009

Lupus

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Vaccination against pathogenic microorganisms is one of the major achievements of modern medicine, but due to an increasing number of reports of adverse reactions the vaccination procedure has induced also considerable debate. It is well known that certain infections are involved in triggering the production of autoantibodies, which could lead to autoimmune adverse reactions in genetically predisposed subjects. Based on these findings it was assumed that vaccinations might induce similar autoimmune reactions. At present there is no clear-cut evidence that vaccinations are associated with overt autoimmune diseases but it has been demonstrated that in genetically predisposed persons vaccination can trigger the production of autoantibodies and autoimmune adverse reactions. The first studies investigating the production of autoantibodies following vaccination were done in dogs and mice. Several studies investigated the production of autoantibodies following vaccination in patients with autoimmune diseases, but there are only limited data on the autoimmune responses after vaccinations in apparently healthy humans. This review summarizes current evidence on the vaccination-induced autoantibodies in apparently healthy subjects including studies in animals and humans.

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Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine

Cited by 50 publications

References 20 publications

Antiphospholipid antibodies in response to infection

Antiphospholipid antibodies in response to infection

Development of autoimmune process in rats immunized with influenza vaccine

Vaccination of healthy subjects and autoantibodies: from mice through dogs to humans

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